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Prostaglandin E synthase 2 [Caenorhabditis elegans]

NCBI Reference Sequence: NP_501913.1

Identical Proteins FASTA Graphics 

LOCUS       NP_501913                347 aa            linear   INV 04-DEC-2024
DEFINITION  Prostaglandin E synthase 2 [Caenorhabditis elegans].
ACCESSION   NP_501913
VERSION     NP_501913.1
DBLINK      BioProject: PRJNA158
DBSOURCE    REFSEQ: accession NM_069512.8
KEYWORDS    RefSeq.
SOURCE      Caenorhabditis elegans
  ORGANISM  Caenorhabditis elegans
            Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
            Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
            Caenorhabditis.
REFERENCE   1  (residues 1 to 347)
  AUTHORS   Sulson,J.E. and Waterston,R.
  CONSRTM   Caenorhabditis elegans Sequencing Consortium
  TITLE     Genome sequence of the nematode C. elegans: a platform for
            investigating biology
  JOURNAL   Science 282 (5396), 2012-2018 (1998)
   PUBMED   9851916
  REMARK    Erratum:[Science 1999 Jan 1;283(5398):35]
REFERENCE   2  (residues 1 to 347)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (04-DEC-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (residues 1 to 347)
  AUTHORS   WormBase.
  CONSRTM   WormBase Consortium
  TITLE     Direct Submission
  JOURNAL   Submitted (17-OCT-2024) WormBase Group, European Bioinformatics
            Institute, Cambridge, CB10 1SA, UK. Email: help@wormbase.org
REFERENCE   4  (residues 1 to 347)
  AUTHORS   Sulson,J.E. and Waterston,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-MAR-2003) Nematode Sequencing Project: Sanger
            Institute, Hinxton, Cambridge CB10 1SA, UK and The Genome Institute
            at Washington University, St. Louis, MO 63110, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by WormBase. The
            reference sequence is identical to CAA94368.
FEATURES             Location/Qualifiers
     source          1..347
                     /organism="Caenorhabditis elegans"
                     /strain="Bristol N2"
                     /db_xref="taxon:6239"
                     /chromosome="IV"
     Protein         1..347
                     /product="Prostaglandin E synthase 2"
                     /calculated_mol_wt=40161
     Region          65..138
                     /region_name="Protein Disulfide Oxidoreductases and Other
                     Proteins with a Thioredoxin fold"
                     /note="The thioredoxin (TRX)-like superfamily is a large,
                     diverse group of proteins containing a TRX fold. Many
                     members contain a classic TRX domain with a redox active
                     CXXC motif. They function as protein disulfide
                     oxidoreductases (PDOs), altering the redox...; cl00388"
                     /db_xref="CDD:469754"
     Region          183..334
                     /region_name="GST_C_mPGES2"
                     /note="C-terminal, alpha helical domain of microsomal
                     Prostaglandin E synthase Type 2; cd03197"
                     /db_xref="CDD:198306"
     Site            order(184,188,195,200,259,261)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:198306"
     Site            order(194,198,222..223,226,292,301,304..305)
                     /site_type="other"
                     /note="N-terminal domain interface [polypeptide binding]"
                     /db_xref="CDD:198306"
     Site            order(205..206,209..210,219,222..223,305,309)
                     /site_type="active"
                     /note="GRX-like active site [active]"
                     /db_xref="CDD:198306"
     CDS             1..347
                     /gene="pges-2"
                     /locus_tag="CELE_R11A8.5"
                     /standard_name="R11A8.5"
                     /coded_by="NM_069512.8:1..1044"
                     /note="Confirmed by transcript evidence"
                     /db_xref="GeneID:177925"
                     /db_xref="WormBase:WBGene00011239"
ORIGIN      
        1 mrffgvrtvq iaslagfswg gsklddiqta klrtcpiqvq qpekvqndvl lsrkvinhld
       61 ksnlklrlyq yetcpfcckv rafldyhgfs yevvevnpvt rsqikfstty kkvpilrsge
      121 ttmtestlii stlatylqrp dqsldqiiqm ypavdstnek gkpvlnypnk ffvmkgkvdg
      181 danmasaree rewrewvdnw fihlispnvy rnwnesvetf rwfeqvgdwh rtfpawervl
      241 avyvgaaamf llsktlkkkh nindereelr kacrdwmaai gpnrqflggd epnladlsly
      301 gamnsfygcs afkevileek iaewwrkmda lvknhdgrka lesrsqk
//
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Reference sequence information

  • RefSeq mRNA
    See reference mRNA sequence for the pges-2 gene (NM_069512.8).

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