CYP18A1, a key enzyme of Drosophila steroid hormone inactivation, is essential for metamorphosis.
Guittard E, Blais C, Maria A, Parvy JP, Pasricha S, Lumb C, Lafont R, Daborn PJ, Dauphin-Villemant C. Dev Biol. 2011 Jan 1; 349(1):35-45. Epub 2010 Oct 7.