LOCUS NP_666405 314 aa linear ROD 26-OCT-2024
DEFINITION olfactory receptor 1143 [Mus musculus].
ACCESSION NP_666405
VERSION NP_666405.1
DBSOURCE REFSEQ: accession NM_146293.2
KEYWORDS RefSeq; RefSeq Select.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 314)
AUTHORS Olender,T., Jones,T.E.M., Bruford,E. and Lancet,D.
TITLE A unified nomenclature for vertebrate olfactory receptors
JOURNAL BMC Evol Biol 20 (1), 42 (2020)
PUBMED 32295537
REMARK Publication Status: Online-Only
REFERENCE 2 (residues 1 to 314)
AUTHORS Young,J.M., Shykind,B.M., Lane,R.P., Tonnes-Priddy,L., Ross,J.A.,
Walker,M., Williams,E.M. and Trask,B.J.
TITLE Odorant receptor expressed sequence tags demonstrate olfactory
expression of over 400 genes, extensive alternate splicing and
unequal expression levels
JOURNAL Genome Biol 4 (11), R71 (2003)
PUBMED 14611657
REFERENCE 3 (residues 1 to 314)
AUTHORS Young,J.M., Friedman,C., Williams,E.M., Ross,J.A., Tonnes-Priddy,L.
and Trask,B.J.
TITLE Different evolutionary processes shaped the mouse and human
olfactory receptor gene families
JOURNAL Hum Mol Genet 11 (5), 535-546 (2002)
PUBMED 11875048
REMARK Erratum:[Hum Mol Genet. 2002 Jul 1;11(14):1683.]
REFERENCE 4 (residues 1 to 314)
AUTHORS Zhang,X. and Firestein,S.
TITLE The olfactory receptor gene superfamily of the mouse
JOURNAL Nat Neurosci 5 (2), 124-133 (2002)
PUBMED 11802173
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
CB173239.1 and AL929424.7.
Summary: Olfactory receptors interact with odorant molecules in the
nose, to initiate a neuronal response that triggers the perception
of a smell. The olfactory receptor proteins are members of a large
family of G-protein-coupled receptors (GPCR) arising from single
coding-exon genes. Olfactory receptors share a 7-transmembrane
domain structure with many neurotransmitter and hormone receptors
and are responsible for the recognition and G protein-mediated
transduction of odorant signals. The olfactory receptor gene family
is the largest in the genome. [provided by RefSeq, Jul 2008].
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on single protein-coding transcript
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..314
/organism="Mus musculus"
/db_xref="taxon:10090"
/chromosome="2"
/map="2 49.96 cM"
Protein 1..314
/product="olfactory receptor 1143"
/note="olfactory receptor MOR177-14;
GA_x6K02T2Q125-49303473-49304405"
/calculated_mol_wt=35082
Region 16..306
/region_name="7tmA_OR5C1-like"
/note="olfactory receptor subfamily 5C1 and related
proteins, member of the class A family of
seven-transmembrane G protein-coupled receptors; cd15945"
/db_xref="CDD:320611"
Region 30..56
/region_name="TM helix 1"
/note="TM helix 1 [structural motif]"
/db_xref="CDD:320611"
Region 63..89
/region_name="TM helix 2"
/note="TM helix 2 [structural motif]"
/db_xref="CDD:320611"
Site order(85,88..89,101..106,108..109,112,157,159..163,199,
202..204,206..208,210..211,256,259..260,262..263,266,
272..273,275..277,280,283..284)
/site_type="other"
/note="putative ligand binding pocket [chemical binding]"
/db_xref="CDD:320611"
Region 101..131
/region_name="TM helix 3"
/note="TM helix 3 [structural motif]"
/db_xref="CDD:320611"
Region 144..165
/region_name="TM helix 4"
/note="TM helix 4 [structural motif]"
/db_xref="CDD:320611"
Region 199..229
/region_name="TM helix 5"
/note="TM helix 5 [structural motif]"
/db_xref="CDD:320611"
Region 236..266
/region_name="TM helix 6"
/note="TM helix 6 [structural motif]"
/db_xref="CDD:320611"
Region 273..298
/region_name="TM helix 7"
/note="TM helix 7 [structural motif]"
/db_xref="CDD:320611"
CDS 1..314
/gene="Or5w18"
/gene_synonym="MOR177-14; Olfr1143"
/coded_by="NM_146293.2:1..945"
/db_xref="CCDS:CCDS16309.1"
/db_xref="GeneID:258290"
/db_xref="MGI:MGI:3030977"
ORIGIN
1 mqrrmegenc ssftefilmg itnnsevkvv lftifllvyl inlignlgmi llikvdpqlq
61 tpmyfflsnl sfcdlcysta vgpkmlmdif gndksiqffg calqffisct fvdsecilla
121 vmafdryqai snpllyttnm snrlcsllva gvyfvgvads lihttltfhl cfcgsneidh
181 ffcdippill lscsdtqvne laiftifgfi elstisgvlv sycyiissvl kissaggrfk
241 afstcashlt avaifqgtvl fmyfrpsssy sldqdkmssl fyilvipmln pliyslrnkd
301 vkealknlkn krcc
//