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atypical chemokine receptor 4 [Homo sapiens]

NCBI Reference Sequence: NP_848540.1

Identical Proteins FASTA Graphics 

LOCUS       NP_848540                350 aa            linear   PRI 27-JUL-2024
DEFINITION  atypical chemokine receptor 4 [Homo sapiens].
ACCESSION   NP_848540
VERSION     NP_848540.1
DBSOURCE    REFSEQ: accession NM_178445.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 350)
  AUTHORS   Naser,I.H., Hamza,A.A., Alhili,A., Faisal,A.N., Ali,M.S.,
            Kadhim,N.A., Suliman,M., Alshahrani,M.Y. and Alawadi,A.
  TITLE     Atypical chemokine receptor 4 (ACKR4/CCX-CKR): A comprehensive
            exploration across physiological and pathological landscapes in
            contemporary research
  JOURNAL   Cell Biochem Funct 42 (3), e4009 (2024)
   PUBMED   38597217
  REMARK    GeneRIF: Atypical chemokine receptor 4 (ACKR4/CCX-CKR): A
            comprehensive exploration across physiological and pathological
            landscapes in contemporary research.
            Review article
REFERENCE   2  (residues 1 to 350)
  AUTHORS   Jiang,C.Y., Wu,L.W., Liu,Y.W., Feng,B., Ye,L.C., Huang,X., He,Y.Y.,
            Shen,Y., Zhu,Y.F., Zhou,X.L., Jiang,D.J., Qi,H.K., Zhang,H. and
            Yan,Y.
  TITLE     Identification of ACKR4 as an immune checkpoint in pulmonary
            arterial hypertension
  JOURNAL   Front Immunol 14, 1153573 (2023)
   PUBMED   37449198
  REMARK    GeneRIF: Identification of ACKR4 as an immune checkpoint in
            pulmonary arterial hypertension.
            Erratum:[Front Immunol. 2024 Feb 20;15:1382832. doi:
            10.3389/fimmu.2024.1382832. PMID: 38444849]
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 350)
  AUTHORS   Friess,M.C., Kritikos,I., Schineis,P., Medina-Sanchez,J.D.,
            Gkountidi,A.O., Vallone,A., Sigmund,E.C., Schwitter,C., Vranova,M.,
            Matti,C., Arasa,J., Saygili Demir,C., Bovay,E., Proulx,S.T.,
            Tomura,M., Rot,A., Legler,D.F., Petrova,T.V. and Halin,C.
  TITLE     Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T
            cell de-adhesion and passive transport by flow in inflamed afferent
            lymphatics
  JOURNAL   Cell Rep 38 (5), 110334 (2022)
   PUBMED   35108538
  REMARK    GeneRIF: Mechanosensitive ACKR4 scavenges CCR7 chemokines to
            facilitate T cell de-adhesion and passive transport by flow in
            inflamed afferent lymphatics.
REFERENCE   4  (residues 1 to 350)
  AUTHORS   Mohammed,M.M., Shaker,O., Ramzy,M.M., Gaber,S.S., Kamel,H.S. and
            Abed El Baky,M.F.
  TITLE     The relation between ACKR4 and CCR7 genes expression and breast
            cancer metastasis
  JOURNAL   Life Sci 279, 119691 (2021)
   PUBMED   34102193
  REMARK    GeneRIF: The relation between ACKR4 and CCR7 genes expression and
            breast cancer metastasis.
REFERENCE   5  (residues 1 to 350)
  AUTHORS   Lewandowska,P., Wierzbicki,J., Zawadzki,M., Agrawal,A. and
            Krzystek-Korpacka,M.
  TITLE     Biphasic Expression of Atypical Chemokine Receptor (ACKR) 2 and
            ACKR4 in Colorectal Neoplasms in Association with Histopathological
            Findings
  JOURNAL   Biomolecules 11 (1), 8 (2020)
   PUBMED   33374792
  REMARK    GeneRIF: Biphasic Expression of Atypical Chemokine Receptor (ACKR)
            2 and ACKR4 in Colorectal Neoplasms in Association with
            Histopathological Findings.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 350)
  AUTHORS   Khoja,H., Wang,G., Ng,C.T., Tucker,J., Brown,T. and Shyamala,V.
  TITLE     Cloning of CCRL1, an orphan seven transmembrane receptor related to
            chemokine receptors, expressed abundantly in the heart
  JOURNAL   Gene 246 (1-2), 229-238 (2000)
   PUBMED   10767544
REFERENCE   7  (residues 1 to 350)
  AUTHORS   Schweickart,V.L., Epp,A., Raport,C.J. and Gray,P.W.
  TITLE     CCR11 is a functional receptor for the monocyte chemoattractant
            protein family of chemokines
  JOURNAL   J Biol Chem 275 (13), 9550-9556 (2000)
   PUBMED   10734104
REFERENCE   8  (residues 1 to 350)
  AUTHORS   Gosling,J., Dairaghi,D.J., Wang,Y., Hanley,M., Talbot,D., Miao,Z.
            and Schall,T.J.
  TITLE     Cutting edge: identification of a novel chemokine receptor that
            binds dendritic cell- and T cell-active chemokines including ELC,
            SLC, and TECK
  JOURNAL   J Immunol 164 (6), 2851-2856 (2000)
   PUBMED   10706668
REFERENCE   9  (residues 1 to 350)
  AUTHORS   Bacon,K.B., Schall,T.J. and Dairaghi,D.J.
  TITLE     RANTES activation of phospholipase D in Jurkat T cells: requirement
            of GTP-binding proteins ARF and RhoA
  JOURNAL   J Immunol 160 (4), 1894-1900 (1998)
   PUBMED   9469451
REFERENCE   10 (residues 1 to 350)
  AUTHORS   Iwatsuki,K., Hashimoto,Y. and Shima,T.
  TITLE     [AH8165, a new muscle relaxant]
  JOURNAL   Masui 26 (3), 342-344 (1977)
   PUBMED   16148
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC020632.16.
            
            Summary: The protein encoded by this gene is a member of the G
            protein-coupled receptor family, and is a receptor for C-C type
            chemokines. This receptor has been shown to bind dendritic cell-
            and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and
            CCL25/TECK. A pseudogene of this gene is found on chromosome 6.
            Alternatively spliced transcript variants encoding the same protein
            have been described. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) differs in the 5' UTR, as
            compared to variant 2. Both variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.1"
     Protein         1..350
                     /product="atypical chemokine receptor 4"
                     /note="orphan seven-transmembrane receptor, chemokine
                     related; chemokine, cc motif, receptor-like protein 1; C-C
                     chemokine receptor type 11; chemocentryx chemokine
                     receptor; C-C CKR-11; CC chemokine receptor-like 1;
                     chemokine (C-C motif) receptor-like 1"
                     /calculated_mol_wt=39783
     Site            6
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9NPB9.1)"
     Site            19
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9NPB9.1)"
     Region          42..314
                     /region_name="7tmA_ACKR4_CCR11"
                     /note="atypical chemokine receptor 4, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; cd15176"
                     /db_xref="CDD:320304"
     Region          42..69
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320304"
     Site            43..63
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NPB9.1)"
     Site            order(48,97,100,116,119..120,184..189,197,200..201,256,
                     263,266,278,282,285..286,289)
                     /site_type="other"
                     /note="putative chemokine binding site [polypeptide
                     binding]"
                     /db_xref="CDD:320304"
     Region          76..101
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320304"
     Site            88..108
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NPB9.1)"
     Region          112..142
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320304"
     Site            114..134
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NPB9.1)"
     Region          152..174
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320304"
     Site            155..175
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NPB9.1)"
     Region          197..226
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320304"
     Site            202..222
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NPB9.1)"
     Region          233..263
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320304"
     Site            241..261
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NPB9.1)"
     Region          282..307
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320304"
     Site            290..310
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NPB9.1)"
     CDS             1..350
                     /gene="ACKR4"
                     /gene_synonym="CC-CKR-11; CCBP2; CCR-11; CCR10; CCR11;
                     CCRL1; CCX CKR; CCX-CKR; CKR-11; PPR1; VSHK1"
                     /coded_by="NM_178445.2:262..1314"
                     /db_xref="CCDS:CCDS3075.1"
                     /db_xref="GeneID:51554"
                     /db_xref="HGNC:HGNC:1611"
                     /db_xref="MIM:606065"
ORIGIN      
        1 maleqnqstd yyyeenemng tydysqyeli cikedvrefa kvflpvflti vfviglagns
       61 mvvaiyayyk kqrtktdvyi lnlavadlll lftlpfwavn avhgwvlgki mckitsalyt
      121 lnfvsgmqfl acisidryva vtkvpsqsgv gkpcwiicfc vwmaaillsi pqlvfytvnd
      181 narcipifpr ylgtsmkali qmleicigfv vpflimgvcy fitartlmkm pnikisrplk
      241 vlltvvivfi vtqlpynivk fcraidiiys litscnmskr mdiaiqvtes ialfhsclnp
      301 ilyvfmgasf knyvmkvakk ygswrrqrqs veefpfdseg pteptstfsi
//
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