LOCUS NP_848540 350 aa linear PRI 27-JUL-2024
DEFINITION atypical chemokine receptor 4 [Homo sapiens].
ACCESSION NP_848540
VERSION NP_848540.1
DBSOURCE REFSEQ: accession NM_178445.2
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 350)
AUTHORS Naser,I.H., Hamza,A.A., Alhili,A., Faisal,A.N., Ali,M.S.,
Kadhim,N.A., Suliman,M., Alshahrani,M.Y. and Alawadi,A.
TITLE Atypical chemokine receptor 4 (ACKR4/CCX-CKR): A comprehensive
exploration across physiological and pathological landscapes in
contemporary research
JOURNAL Cell Biochem Funct 42 (3), e4009 (2024)
PUBMED 38597217
REMARK GeneRIF: Atypical chemokine receptor 4 (ACKR4/CCX-CKR): A
comprehensive exploration across physiological and pathological
landscapes in contemporary research.
Review article
REFERENCE 2 (residues 1 to 350)
AUTHORS Jiang,C.Y., Wu,L.W., Liu,Y.W., Feng,B., Ye,L.C., Huang,X., He,Y.Y.,
Shen,Y., Zhu,Y.F., Zhou,X.L., Jiang,D.J., Qi,H.K., Zhang,H. and
Yan,Y.
TITLE Identification of ACKR4 as an immune checkpoint in pulmonary
arterial hypertension
JOURNAL Front Immunol 14, 1153573 (2023)
PUBMED 37449198
REMARK GeneRIF: Identification of ACKR4 as an immune checkpoint in
pulmonary arterial hypertension.
Erratum:[Front Immunol. 2024 Feb 20;15:1382832. doi:
10.3389/fimmu.2024.1382832. PMID: 38444849]
Publication Status: Online-Only
REFERENCE 3 (residues 1 to 350)
AUTHORS Friess,M.C., Kritikos,I., Schineis,P., Medina-Sanchez,J.D.,
Gkountidi,A.O., Vallone,A., Sigmund,E.C., Schwitter,C., Vranova,M.,
Matti,C., Arasa,J., Saygili Demir,C., Bovay,E., Proulx,S.T.,
Tomura,M., Rot,A., Legler,D.F., Petrova,T.V. and Halin,C.
TITLE Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T
cell de-adhesion and passive transport by flow in inflamed afferent
lymphatics
JOURNAL Cell Rep 38 (5), 110334 (2022)
PUBMED 35108538
REMARK GeneRIF: Mechanosensitive ACKR4 scavenges CCR7 chemokines to
facilitate T cell de-adhesion and passive transport by flow in
inflamed afferent lymphatics.
REFERENCE 4 (residues 1 to 350)
AUTHORS Mohammed,M.M., Shaker,O., Ramzy,M.M., Gaber,S.S., Kamel,H.S. and
Abed El Baky,M.F.
TITLE The relation between ACKR4 and CCR7 genes expression and breast
cancer metastasis
JOURNAL Life Sci 279, 119691 (2021)
PUBMED 34102193
REMARK GeneRIF: The relation between ACKR4 and CCR7 genes expression and
breast cancer metastasis.
REFERENCE 5 (residues 1 to 350)
AUTHORS Lewandowska,P., Wierzbicki,J., Zawadzki,M., Agrawal,A. and
Krzystek-Korpacka,M.
TITLE Biphasic Expression of Atypical Chemokine Receptor (ACKR) 2 and
ACKR4 in Colorectal Neoplasms in Association with Histopathological
Findings
JOURNAL Biomolecules 11 (1), 8 (2020)
PUBMED 33374792
REMARK GeneRIF: Biphasic Expression of Atypical Chemokine Receptor (ACKR)
2 and ACKR4 in Colorectal Neoplasms in Association with
Histopathological Findings.
Publication Status: Online-Only
REFERENCE 6 (residues 1 to 350)
AUTHORS Khoja,H., Wang,G., Ng,C.T., Tucker,J., Brown,T. and Shyamala,V.
TITLE Cloning of CCRL1, an orphan seven transmembrane receptor related to
chemokine receptors, expressed abundantly in the heart
JOURNAL Gene 246 (1-2), 229-238 (2000)
PUBMED 10767544
REFERENCE 7 (residues 1 to 350)
AUTHORS Schweickart,V.L., Epp,A., Raport,C.J. and Gray,P.W.
TITLE CCR11 is a functional receptor for the monocyte chemoattractant
protein family of chemokines
JOURNAL J Biol Chem 275 (13), 9550-9556 (2000)
PUBMED 10734104
REFERENCE 8 (residues 1 to 350)
AUTHORS Gosling,J., Dairaghi,D.J., Wang,Y., Hanley,M., Talbot,D., Miao,Z.
and Schall,T.J.
TITLE Cutting edge: identification of a novel chemokine receptor that
binds dendritic cell- and T cell-active chemokines including ELC,
SLC, and TECK
JOURNAL J Immunol 164 (6), 2851-2856 (2000)
PUBMED 10706668
REFERENCE 9 (residues 1 to 350)
AUTHORS Bacon,K.B., Schall,T.J. and Dairaghi,D.J.
TITLE RANTES activation of phospholipase D in Jurkat T cells: requirement
of GTP-binding proteins ARF and RhoA
JOURNAL J Immunol 160 (4), 1894-1900 (1998)
PUBMED 9469451
REFERENCE 10 (residues 1 to 350)
AUTHORS Iwatsuki,K., Hashimoto,Y. and Shima,T.
TITLE [AH8165, a new muscle relaxant]
JOURNAL Masui 26 (3), 342-344 (1977)
PUBMED 16148
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC020632.16.
Summary: The protein encoded by this gene is a member of the G
protein-coupled receptor family, and is a receptor for C-C type
chemokines. This receptor has been shown to bind dendritic cell-
and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and
CCL25/TECK. A pseudogene of this gene is found on chromosome 6.
Alternatively spliced transcript variants encoding the same protein
have been described. [provided by RefSeq, Jul 2013].
Transcript Variant: This variant (1) differs in the 5' UTR, as
compared to variant 2. Both variants encode the same protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
FEATURES Location/Qualifiers
source 1..350
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="3"
/map="3q22.1"
Protein 1..350
/product="atypical chemokine receptor 4"
/note="orphan seven-transmembrane receptor, chemokine
related; chemokine, cc motif, receptor-like protein 1; C-C
chemokine receptor type 11; chemocentryx chemokine
receptor; C-C CKR-11; CC chemokine receptor-like 1;
chemokine (C-C motif) receptor-like 1"
/calculated_mol_wt=39783
Site 6
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q9NPB9.1)"
Site 19
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q9NPB9.1)"
Region 42..314
/region_name="7tmA_ACKR4_CCR11"
/note="atypical chemokine receptor 4, member of the class
A family of seven-transmembrane G protein-coupled
receptors; cd15176"
/db_xref="CDD:320304"
Region 42..69
/region_name="TM helix 1"
/note="TM helix 1 [structural motif]"
/db_xref="CDD:320304"
Site 43..63
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (Q9NPB9.1)"
Site order(48,97,100,116,119..120,184..189,197,200..201,256,
263,266,278,282,285..286,289)
/site_type="other"
/note="putative chemokine binding site [polypeptide
binding]"
/db_xref="CDD:320304"
Region 76..101
/region_name="TM helix 2"
/note="TM helix 2 [structural motif]"
/db_xref="CDD:320304"
Site 88..108
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (Q9NPB9.1)"
Region 112..142
/region_name="TM helix 3"
/note="TM helix 3 [structural motif]"
/db_xref="CDD:320304"
Site 114..134
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (Q9NPB9.1)"
Region 152..174
/region_name="TM helix 4"
/note="TM helix 4 [structural motif]"
/db_xref="CDD:320304"
Site 155..175
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (Q9NPB9.1)"
Region 197..226
/region_name="TM helix 5"
/note="TM helix 5 [structural motif]"
/db_xref="CDD:320304"
Site 202..222
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (Q9NPB9.1)"
Region 233..263
/region_name="TM helix 6"
/note="TM helix 6 [structural motif]"
/db_xref="CDD:320304"
Site 241..261
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (Q9NPB9.1)"
Region 282..307
/region_name="TM helix 7"
/note="TM helix 7 [structural motif]"
/db_xref="CDD:320304"
Site 290..310
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (Q9NPB9.1)"
CDS 1..350
/gene="ACKR4"
/gene_synonym="CC-CKR-11; CCBP2; CCR-11; CCR10; CCR11;
CCRL1; CCX CKR; CCX-CKR; CKR-11; PPR1; VSHK1"
/coded_by="NM_178445.2:262..1314"
/db_xref="CCDS:CCDS3075.1"
/db_xref="GeneID:51554"
/db_xref="HGNC:HGNC:1611"
/db_xref="MIM:606065"
ORIGIN
1 maleqnqstd yyyeenemng tydysqyeli cikedvrefa kvflpvflti vfviglagns
61 mvvaiyayyk kqrtktdvyi lnlavadlll lftlpfwavn avhgwvlgki mckitsalyt
121 lnfvsgmqfl acisidryva vtkvpsqsgv gkpcwiicfc vwmaaillsi pqlvfytvnd
181 narcipifpr ylgtsmkali qmleicigfv vpflimgvcy fitartlmkm pnikisrplk
241 vlltvvivfi vtqlpynivk fcraidiiys litscnmskr mdiaiqvtes ialfhsclnp
301 ilyvfmgasf knyvmkvakk ygswrrqrqs veefpfdseg pteptstfsi
//