LOCUS NP_996776 267 aa linear PRI 20-SEP-2024
DEFINITION membrane-spanning 4-domains subfamily A member 10 [Homo sapiens].
ACCESSION NP_996776 XP_291890
VERSION NP_996776.2
DBSOURCE REFSEQ: accession NM_206893.4
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 267)
AUTHORS Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
Ivarsson,Y.
TITLE Proteome-scale mapping of binding sites in the unstructured regions
of the human proteome
JOURNAL Mol Syst Biol 18 (1), e10584 (2022)
PUBMED 35044719
REFERENCE 2 (residues 1 to 267)
AUTHORS Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
Harper,J.W. and Gygi,S.P.
TITLE Dual proteome-scale networks reveal cell-specific remodeling of the
human interactome
JOURNAL Cell 184 (11), 3022-3040 (2021)
PUBMED 33961781
REFERENCE 3 (residues 1 to 267)
AUTHORS Liang,Y., Buckley,T.R., Tu,L., Langdon,S.D. and Tedder,T.F.
TITLE Structural organization of the human MS4A gene cluster on
Chromosome 11q12
JOURNAL Immunogenetics 53 (5), 357-368 (2001)
PUBMED 11486273
REFERENCE 4 (residues 1 to 267)
AUTHORS Liang,Y. and Tedder,T.F.
TITLE Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene
family: sixteen new MS4A family members expressed in human and
mouse
JOURNAL Genomics 72 (2), 119-127 (2001)
PUBMED 11401424
REFERENCE 5 (residues 1 to 267)
AUTHORS Ishibashi,K., Suzuki,M., Sasaki,S. and Imai,M.
TITLE Identification of a new multigene four-transmembrane family (MS4A)
related to CD20, HTm4 and beta subunit of the high-affinity IgE
receptor
JOURNAL Gene 264 (1), 87-93 (2001)
PUBMED 11245982
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AP004243.2 and AK122633.1.
On Feb 8, 2008 this sequence version replaced NP_996776.1.
Summary: Most MS4A genes, including MS4A10, encode proteins with at
least 4 potential transmembrane domains and N- and C-terminal
cytoplasmic domains encoded by distinct exons.[supplied by OMIM,
Apr 2004].
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data because transcript sequence consistent with
the reference genome assembly was not available for all regions of
the RefSeq transcript. The extent of this transcript is supported
by transcript alignments.
##Evidence-Data-START##
Transcript exon combination :: AK122633.1, BC137259.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA2144835, SAMEA2152474
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000308287.2/ ENSP00000311862.1
RefSeq Select criteria :: based on conservation, expression
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..267
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q12.2"
Protein 1..267
/product="membrane-spanning 4-domains subfamily A member
10"
/note="CD20 antigen-like 7; membrane-spanning 4-domains,
subfamily A, member 10"
/calculated_mol_wt=29616
Region 60..193
/region_name="CD20"
/note="CD20-like family; pfam04103"
/db_xref="CDD:461174"
Site 62..82
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (Q96PG2.3)"
Site 92..112
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (Q96PG2.3)"
Site 122..142
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (Q96PG2.3)"
Site 172..192
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (Q96PG2.3)"
CDS 1..267
/gene="MS4A10"
/gene_synonym="CD20L7; MS4A9"
/coded_by="NM_206893.4:112..915"
/db_xref="CCDS:CCDS7992.1"
/db_xref="GeneID:341116"
/db_xref="HGNC:HGNC:13368"
/db_xref="MIM:608403"
ORIGIN
1 mkaeatvips rcarglpswq vlspvqpwqt sapqnttqpk llaphqheks qkkssllkel
61 gafhitiall hlvfggylas ivknlhlvvl kswypfwgaa sflisgilai tmktfsktyl
121 kmlclmtnli slfcvlsglf viskdlfles pfespiwrmy pnstvhiqrl elallcftvl
181 elflpvptav tawrgdcpsa knddaclvpn tplhlkglpv epppsyqsvi qgdaqhkqhq
241 rlrevkqvap dtwivtdgaa iwtqtan
//