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RecName: Full=Heat shock protein SSA2

UniProtKB/Swiss-Prot: P10592.3

Identical Proteins FASTA Graphics 

LOCUS       HSP72_YEAST              639 aa            linear   PLN 27-NOV-2024
DEFINITION  RecName: Full=Heat shock protein SSA2.
ACCESSION   P10592
VERSION     P10592.3
DBSOURCE    UniProtKB: locus HSP72_YEAST, accession P10592;
            class: standard.
            extra accessions:D6VXY0
            created: Jul 1, 1989.
            sequence updated: Jan 23, 2007.
            annotation updated: Nov 27, 2024.
            xrefs: X12927.1, CAA31394.1, Z73129.1, CAA97472.1, X97560.1,
            CAA66167.1, BK006945.2, DAA09296.1, S20139, NP_013076.1
            xrefs (non-sequence databases): AlphaFoldDB:P10592, SMR:P10592,
            BioGRID:31229, ComplexPortal:CPX-1276, ComplexPortal:CPX-1883,
            DIP:DIP-2265N, IntAct:P10592, MINT:P10592, STRING:4932.YLL024C,
            CarbonylDB:P10592, iPTMnet:P10592, PaxDb:4932-YLL024C,
            PeptideAtlas:P10592, EnsemblFungi:YLL024C_mRNA,
            EnsemblFungi:YLL024C, EnsemblFungi:YLL024C, GeneID:850636,
            KEGG:sce:YLL024C, AGR:SGD:S000003947, SGD:S000003947,
            VEuPathDB:FungiDB:YLL024C, eggNOG:KOG0101,
            GeneTree:ENSGT00940000176322, HOGENOM:CLU_005965_7_0_1,
            InParanoid:P10592, OMA:VNEAESY, OrthoDB:143at2759,
            BioCyc:YEAST:G3O-32128-MONOMER, Reactome:R-SCE-3371453,
            Reactome:R-SCE-3371497, Reactome:R-SCE-3371571,
            Reactome:R-SCE-6798695, Reactome:R-SCE-8876725,
            BioGRID-ORCS:850636, PRO:PR:P10592, Proteomes:UP000002311,
            RNAct:P10592, GO:0005737, GO:0005829, GO:1903561, GO:0009277,
            GO:0000329, GO:0005739, GO:0005634, GO:0005886, GO:0017053,
            GO:0005524, GO:0016887, GO:0140662, GO:0031072, GO:0044183,
            GO:0000049, GO:0051082, GO:0009267, GO:0051085, GO:0045892,
            GO:0043161, GO:0006457, GO:0042026, GO:0070482, GO:0006616,
            GO:0035719, CDD:cd10233, FunFam:2.60.34.10:FF:000002,
            FunFam:3.90.640.10:FF:000002, FunFam:3.30.30.30:FF:000001,
            FunFam:3.30.420.40:FF:000135, FunFam:1.20.1270.10:FF:000016,
            FunFam:3.30.420.40:FF:000026, Gene3D:1.20.1270.10,
            Gene3D:3.30.30.30, Gene3D:3.30.420.40, InterPro:IPR043129,
            InterPro:IPR018181, InterPro:IPR029048, InterPro:IPR029047,
            InterPro:IPR013126, PANTHER:PTHR19375:SF395, PANTHER:PTHR19375,
            Pfam:PF00012, PRINTS:PR00301, SUPFAM:SSF53067, SUPFAM:SSF100934,
            SUPFAM:SSF100920, PROSITE:PS00297, PROSITE:PS00329, PROSITE:PS01036
KEYWORDS    Acetylation; ATP-binding; Cell wall; Cytoplasm; Direct protein
            sequencing; Isopeptide bond; Nucleotide-binding; Phosphoprotein;
            Reference proteome; Secreted; Stress response; Ubl conjugation.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (residues 1 to 639)
  AUTHORS   Slater,M.R. and Craig,E.A.
  TITLE     The SSA1 and SSA2 genes of the yeast Saccharomyces cerevisiae
  JOURNAL   Nucleic Acids Res 17 (2), 805-806 (1989)
   PUBMED   2644626
  REMARK    NUCLEOTIDE SEQUENCE [GENOMIC DNA].;
            STRAIN=ATCC 204508 / S288c
REFERENCE   2  (residues 1 to 639)
  AUTHORS   Purnelle,B. and Goffeau,A.
  TITLE     The sequence of 32b on the left arm of yeast chromosome XII reveals
            six known genes, a new member of the seripauperins family and a new
            ABS transporter homologous to the human multidrug resistance
            protein
  JOURNAL   Yeast 13 (2), 183-188 (1997)
   PUBMED   9046100
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
            STRAIN=ATCC 204508 / S288c
REFERENCE   3  (residues 1 to 639)
  AUTHORS   Engel,S.R., Dietrich,F.S., Fisk,D.G., Binkley,G., Balakrishnan,R.,
            Costanzo,M.C., Dwight,S.S., Hitz,B.C., Karra,K., Nash,R.S.,
            Weng,S., Wong,E.D., Lloyd,P., Skrzypek,M.S., Miyasato,S.R.,
            Simison,M. and Cherry,J.M.
  TITLE     The reference genome sequence of Saccharomyces cerevisiae: then and
            now
  JOURNAL   G3 (Bethesda) 4 (3), 389-398 (2014)
   PUBMED   24374639
  REMARK    GENOME REANNOTATION.;
            STRAIN=ATCC 204508 / S288c
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 639)
  AUTHORS   Johnston,M., Hillier,L.W., Riles,L., Albermann,K., Andre,B.,
            Ansorge,W., Benes,V., Brueckner,M., Delius,H., Dubois,E.,
            Duesterhoeft,A., Entian,K.-D., Floeth,M., Goffeau,A., Hebling,U.,
            Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K.,
            Koetter,P., Louis,E.J., Messenguy,F., Mewes,H.-W., Miosga,T.,
            Moestl,D., Mueller-Auer,S., Nentwich,U., Obermaier,B.,
            Piravandi,E., Pohl,T.M., Portetelle,D., Purnelle,B., Rechmann,S.,
            Rieger,M., Rinke,M., Rose,M., Scharfe,M., Scherens,B., Scholler,P.,
            Schwager,C., Schwarz,S., Underwood,A.P., Urrestarazu,L.A.,
            Vandenbol,M., Verhasselt,P., Vierendeels,F., Voet,M., Volckaert,G.,
            Voss,H., Wambutt,R., Wedler,E., Wedler,H., Zimmermann,F.K.,
            Zollner,A., Hani,J. and Hoheisel,J.D.
  TITLE     The nucleotide sequence of Saccharomyces cerevisiae chromosome XII
  JOURNAL   Nature 387 (6632 Suppl), 87-90 (1997)
   PUBMED   9169871
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
            STRAIN=ATCC 204508 / S288c
REFERENCE   5  (residues 1 to 639)
  AUTHORS   Garrels,J.I., Futcher,B., Kobayashi,R., Latter,G.I., Schwender,B.,
            Volpe,T., Warner,J.R. and McLaughlin,C.S.
  TITLE     Protein identifications for a Saccharomyces cerevisiae protein
            database
  JOURNAL   Electrophoresis 15 (11), 1466-1486 (1994)
   PUBMED   7895733
  REMARK    PROTEIN SEQUENCE OF 92-98 AND 326-342.;
            STRAIN=ATCC 204508 / S288c
REFERENCE   6  (residues 1 to 639)
  AUTHORS   Norbeck,J. and Blomberg,A.
  TITLE     Protein expression during exponential growth in 0.7 M NaCl medium
            of Saccharomyces cerevisiae
  JOURNAL   FEMS Microbiol Lett 137 (1), 1-8 (1996)
   PUBMED   8935650
  REMARK    PROTEIN SEQUENCE OF 187-196.;
            STRAIN=ATCC 38531 / Y41
REFERENCE   7  (residues 1 to 639)
  AUTHORS   Garrels,J.I., McLaughlin,C.S., Warner,J.R., Futcher,B.,
            Latter,G.I., Kobayashi,R., Schwender,B., Volpe,T., Anderson,D.S.,
            Mesquita-Fuentes,R. and Payne,W.E.
  TITLE     Proteome studies of Saccharomyces cerevisiae: identification and
            characterization of abundant proteins
  JOURNAL   Electrophoresis 18 (8), 1347-1360 (1997)
   PUBMED   9298649
  REMARK    ACETYLATION AT SER-2, AND PHOSPHORYLATION.
REFERENCE   8  (residues 1 to 639)
  AUTHORS   Li,X.S., Reddy,M.S., Baev,D. and Edgerton,M.
  TITLE     Candida albicans Ssa1/2p is the cell envelope binding protein for
            human salivary histatin 5
  JOURNAL   J Biol Chem 278 (31), 28553-28561 (2003)
   PUBMED   12761219
  REMARK    FUNCTION, AND INTERACTION WITH HUMAN HTN3.
REFERENCE   9  (residues 1 to 639)
  AUTHORS   Ghaemmaghami,S., Huh,W.K., Bower,K., Howson,R.W., Belle,A.,
            Dephoure,N., O'Shea,E.K. and Weissman,J.S.
  TITLE     Global analysis of protein expression in yeast
  JOURNAL   Nature 425 (6959), 737-741 (2003)
   PUBMED   14562106
  REMARK    LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
REFERENCE   10 (residues 1 to 639)
  AUTHORS   Peng,J., Schwartz,D., Elias,J.E., Thoreen,C.C., Cheng,D.,
            Marsischky,G., Roelofs,J., Finley,D. and Gygi,S.P.
  TITLE     A proteomics approach to understanding protein ubiquitination
  JOURNAL   Nat Biotechnol 21 (8), 921-926 (2003)
   PUBMED   12872131
  REMARK    UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-556, AND
            IDENTIFICATION BY MASS SPECTROMETRY.;
            STRAIN=SUB592
REFERENCE   11 (residues 1 to 639)
  AUTHORS   Chi,A., Huttenhower,C., Geer,L.Y., Coon,J.J., Syka,J.E., Bai,D.L.,
            Shabanowitz,J., Burke,D.J., Troyanskaya,O.G. and Hunt,D.F.
  TITLE     Analysis of phosphorylation sites on proteins from Saccharomyces
            cerevisiae by electron transfer dissociation (ETD) mass
            spectrometry
  JOURNAL   Proc Natl Acad Sci U S A 104 (7), 2193-2198 (2007)
   PUBMED   17287358
  REMARK    IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
REFERENCE   12 (residues 1 to 639)
  AUTHORS   Calvert,M.E., Keck,K.M., Ptak,C., Shabanowitz,J., Hunt,D.F. and
            Pemberton,L.F.
  TITLE     Phosphorylation by casein kinase 2 regulates Nap1 localization and
            function
  JOURNAL   Mol Cell Biol 28 (4), 1313-1325 (2008)
   PUBMED   18086883
  REMARK    INTERACTION WITH NAP1, AND IDENTIFICATION BY MASS SPECTROMETRY.
REFERENCE   13 (residues 1 to 639)
  AUTHORS   Albuquerque,C.P., Smolka,M.B., Payne,S.H., Bafna,V., Eng,J. and
            Zhou,H.
  TITLE     A multidimensional chromatography technology for in-depth
            phosphoproteome analysis
  JOURNAL   Mol Cell Proteomics 7 (7), 1389-1396 (2008)
   PUBMED   18407956
  REMARK    PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20, AND
            IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
REFERENCE   14 (residues 1 to 639)
  AUTHORS   Holt,L.J., Tuch,B.B., Villen,J., Johnson,A.D., Gygi,S.P. and
            Morgan,D.O.
  TITLE     Global analysis of Cdk1 substrate phosphorylation sites provides
            insights into evolution
  JOURNAL   Science 325 (5948), 1682-1686 (2009)
   PUBMED   19779198
  REMARK    IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
REFERENCE   15 (residues 1 to 639)
  AUTHORS   Van Damme,P., Lasa,M., Polevoda,B., Gazquez,C., Elosegui-Artola,A.,
            Kim,D.S., De Juan-Pardo,E., Demeyer,K., Hole,K., Larrea,E.,
            Timmerman,E., Prieto,J., Arnesen,T., Sherman,F., Gevaert,K. and
            Aldabe,R.
  TITLE     N-terminal acetylome analyses and functional insights of the
            N-terminal acetyltransferase NatB
  JOURNAL   Proc Natl Acad Sci U S A 109 (31), 12449-12454 (2012)
   PUBMED   22814378
  REMARK    ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR
            METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS
            SPECTROMETRY [LARGE SCALE ANALYSIS].
REFERENCE   16 (residues 1 to 639)
  AUTHORS   Starita,L.M., Lo,R.S., Eng,J.K., von Haller,P.D. and Fields,S.
  TITLE     Sites of ubiquitin attachment in Saccharomyces cerevisiae
  JOURNAL   Proteomics 12 (2), 236-240 (2012)
   PUBMED   22106047
  REMARK    UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-556, AND
            IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
COMMENT     On Apr 6, 2005 this sequence version replaced gi:101351.
            [FUNCTION] May play a role in the transport of polypeptides both
            across the mitochondrial membranes and into the endoplasmic
            reticulum. A functional difference between SSA1 and SSA2 proteins
            is expected. SSA2 can participate in the ATP-dependent disassembly
            of clathrin-coated vesicles. {ECO:0000269|PubMed:12761219}.
            [SUBUNIT] Binds human HTN3/histatin-5, a peptide from saliva, and
            mediates its fungicidal activity. Interacts with NAP1.
            {ECO:0000269|PubMed:12761219, ECO:0000269|PubMed:18086883}.
            [INTERACTION] P10592; P53940: APJ1; NbExp=2; IntAct=EBI-8603,
            EBI-2612341; P10592; P18900: COQ1; NbExp=2; IntAct=EBI-8603,
            EBI-4912; P10592; P22696: ESS1; NbExp=2; IntAct=EBI-8603, EBI-6679;
            P10592; P02829: HSP82; NbExp=3; IntAct=EBI-8603, EBI-8659; P10592;
            P25605: ILV6; NbExp=2; IntAct=EBI-8603, EBI-9087; P10592; P17505:
            MDH1; NbExp=2; IntAct=EBI-8603, EBI-10594; P10592; P07275: PUT2;
            NbExp=2; IntAct=EBI-8603, EBI-14303; P10592; P25294: SIS1; NbExp=3;
            IntAct=EBI-8603, EBI-17244; P10592; Q06385: VPS74; NbExp=2;
            IntAct=EBI-8603, EBI-35395; P10592; P34761: WHI3; NbExp=2;
            IntAct=EBI-8603, EBI-20537; P10592; Q05016: YMR226C; NbExp=2;
            IntAct=EBI-8603, EBI-27486.
            [SUBCELLULAR LOCATION] Cytoplasm. Secreted, cell wall.
            [MISCELLANEOUS] Present with 364000 molecules/cell in log phase SD
            medium. {ECO:0000269|PubMed:14562106}.
            [SIMILARITY] Belongs to the heat shock protein 70 family.
            {ECO:0000305}.
FEATURES             Location/Qualifiers
     source          1..639
                     /organism="Saccharomyces cerevisiae S288C"
                     /db_xref="taxon:559292"
     gene            1..639
                     /gene="SSA2"
                     /locus_tag="YLL024C"
                     /gene_synonym="L0931"
     Protein         1..639
                     /product="Heat shock protein SSA2"
                     /UniProtKB_evidence="Evidence at protein level"
     Region          2..639
                     /region_name="Mature chain"
                     /note="Heat shock protein SSA2. /id=PRO_0000078386."
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000269|PubMed:9298649,
                     ECO:0007744|PubMed:22814378."
     Region          4..639
                     /region_name="PTZ00009"
                     /note="heat shock 70 kDa protein; Provisional"
                     /db_xref="CDD:240227"
     Site            20
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18407956."
     Site            551
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10591."
     Bond            bond(556)
                     /bond_type="xlink"
                     /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
                     G-Cter in ubiquitin).
                     /evidence=ECO:0007744|PubMed:22106047."
     Site            603
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10591."
     Region          605..639
                     /region_name="Region of interest in the sequence"
                     /note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
ORIGIN      
        1 mskavgidlg ttyscvahfs ndrvdiiand qgnrttpsfv gftdterlig daaknqaamn
       61 pantvfdakr ligrnfndpe vqgdmkhfpf klidvdgkpq iqvefkgetk nftpeqissm
      121 vlgkmketae sylgakvnda vvtvpayfnd sqrqatkdag tiaglnvlri ineptaaaia
      181 ygldkkgkee hvlifdlggg tfdvsllsie dgifevkata gdthlggedf dnrlvnhfiq
      241 efkrknkkdl stnqralrrl rtacerakrt lsssaqtsve idslfegidf ytsitrarfe
      301 elcadlfrst ldpvekvlrd akldksqvde ivlvggstri pkvqklvtdy fngkepnrsi
      361 npdeavayga avqaailtgd essktqdlll ldvaplslgi etaggvmtkl iprnstiptk
      421 ksevfstyad nqpgvliqvf egeraktkdn nllgkfelsg ippaprgvpq ievtfdvdsn
      481 gilnvsavek gtgksnkiti tndkgrlske diekmvaeae kfkeedekes qriasknqle
      541 siayslknti seagdkleqa dkdavtkkae etiawldsnt tatkeefddq lkelqevanp
      601 imsklyqagg apegaapggf pggappapea egptveevd
//
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Reference sequence information

  • RefSeq protein
    See the reference protein sequence for Hsp70 family chaperone SSA2 (NP_013076.1).

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