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RecName: Full=Ribosome-interacting GTPase 1; AltName: Full=GTP-binding protein RBG1; AltName: Full=Genetically interacts with ribosomal genes protein 1

UniProtKB/Swiss-Prot: P39729.1

Identical Proteins FASTA Graphics 

LOCUS       RBG1_YEAST               369 aa            linear   PLN 27-NOV-2024
DEFINITION  RecName: Full=Ribosome-interacting GTPase 1; AltName:
            Full=GTP-binding protein RBG1; AltName: Full=Genetically interacts
            with ribosomal genes protein 1.
ACCESSION   P39729
VERSION     P39729.1
DBSOURCE    UniProtKB: locus RBG1_YEAST, accession P39729;
            class: standard.
            extra accessions:D6VPI1
            created: Feb 1, 1995.
            sequence updated: Feb 1, 1995.
            annotation updated: Nov 27, 2024.
            xrefs: U12980.3, AAC04995.1, AY693042.1, AAT93061.1, BK006935.2,
            DAA06951.1, S51983, NP_009364.1, 4A9A_A, 4A9A_B
            xrefs (non-sequence databases): PDBsum:4A9A, AlphaFoldDB:P39729,
            SMR:P39729, BioGRID:31729, DIP:DIP-1750N, IntAct:P39729,
            MINT:P39729, STRING:4932.YAL036C, iPTMnet:P39729,
            PaxDb:4932-YAL036C, PeptideAtlas:P39729, EnsemblFungi:YAL036C_mRNA,
            EnsemblFungi:YAL036C, EnsemblFungi:YAL036C, GeneID:851195,
            KEGG:sce:YAL036C, AGR:SGD:S000000034, SGD:S000000034,
            VEuPathDB:FungiDB:YAL036C, eggNOG:KOG1487,
            GeneTree:ENSGT00940000153340, HOGENOM:CLU_044997_0_0_1,
            InParanoid:P39729, OMA:SAKHPGQ, OrthoDB:146471at2759,
            BioCyc:YEAST:G3O-28846-MONOMER, BioGRID-ORCS:851195,
            EvolutionaryTrace:P39729, PRO:PR:P39729, Proteomes:UP000002311,
            RNAct:P39729, GO:0005737, GO:0010494, GO:0005777, GO:0005525,
            GO:0003924, GO:0002181, GO:1903833, CDD:cd01896, CDD:cd17230,
            FunFam:3.10.20.30:FF:000003, FunFam:3.40.50.300:FF:000740,
            Gene3D:3.10.20.30, Gene3D:6.10.140.1070, InterPro:IPR012675,
            InterPro:IPR045001, InterPro:IPR031167, InterPro:IPR006073,
            InterPro:IPR031662, InterPro:IPR006074, InterPro:IPR027417,
            InterPro:IPR005225, InterPro:IPR004095, InterPro:IPR012676,
            NCBIfam:TIGR00231, PANTHER:PTHR43127:SF1, PANTHER:PTHR43127,
            Pfam:PF01926, Pfam:PF16897, Pfam:PF02824, PRINTS:PR00326,
            SUPFAM:SSF52540, SUPFAM:SSF81271, PROSITE:PS51710, PROSITE:PS00905,
            PROSITE:PS51880
KEYWORDS    3D-structure; Acetylation; Cytoplasm; GTP-binding;
            Nucleotide-binding; Reference proteome.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (residues 1 to 369)
  AUTHORS   Bussey,H., Kaback,D.B., Zhong,W.-W., Vo,D.H., Clark,M.W.,
            Fortin,N., Hall,J., Ouellette,B.F.F., Keng,T., Barton,A.B., Su,Y.,
            Davies,C.J. and Storms,R.K.
  TITLE     The nucleotide sequence of chromosome I from Saccharomyces
            cerevisiae
  JOURNAL   Proc Natl Acad Sci U S A 92 (9), 3809-3813 (1995)
   PUBMED   7731988
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
            STRAIN=ATCC 204508 / S288c
REFERENCE   2  (residues 1 to 369)
  AUTHORS   Engel,S.R., Dietrich,F.S., Fisk,D.G., Binkley,G., Balakrishnan,R.,
            Costanzo,M.C., Dwight,S.S., Hitz,B.C., Karra,K., Nash,R.S.,
            Weng,S., Wong,E.D., Lloyd,P., Skrzypek,M.S., Miyasato,S.R.,
            Simison,M. and Cherry,J.M.
  TITLE     The reference genome sequence of Saccharomyces cerevisiae: then and
            now
  JOURNAL   G3 (Bethesda) 4 (3), 389-398 (2014)
   PUBMED   24374639
  REMARK    GENOME REANNOTATION.;
            STRAIN=ATCC 204508 / S288c
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 369)
  AUTHORS   Hu,Y., Rolfs,A., Bhullar,B., Murthy,T.V., Zhu,C., Berger,M.F.,
            Camargo,A.A., Kelley,F., McCarron,S., Jepson,D., Richardson,A.,
            Raphael,J., Moreira,D., Taycher,E., Zuo,D., Mohr,S., Kane,M.F.,
            Williamson,J., Simpson,A., Bulyk,M.L., Harlow,E., Marsischky,G.,
            Kolodner,R.D. and LaBaer,J.
  TITLE     Approaching a complete repository of sequence-verified
            protein-encoding clones for Saccharomyces cerevisiae
  JOURNAL   Genome Res 17 (4), 536-543 (2007)
   PUBMED   17322287
  REMARK    NUCLEOTIDE SEQUENCE [GENOMIC DNA].;
            STRAIN=ATCC 204508 / S288c
REFERENCE   4  (residues 1 to 369)
  AUTHORS   Huh,W.K., Falvo,J.V., Gerke,L.C., Carroll,A.S., Howson,R.W.,
            Weissman,J.S. and O'Shea,E.K.
  TITLE     Global analysis of protein localization in budding yeast
  JOURNAL   Nature 425 (6959), 686-691 (2003)
   PUBMED   14562095
  REMARK    SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
REFERENCE   5  (residues 1 to 369)
  AUTHORS   Ghaemmaghami,S., Huh,W.K., Bower,K., Howson,R.W., Belle,A.,
            Dephoure,N., O'Shea,E.K. and Weissman,J.S.
  TITLE     Global analysis of protein expression in yeast
  JOURNAL   Nature 425 (6959), 737-741 (2003)
   PUBMED   14562106
  REMARK    LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
REFERENCE   6  (residues 1 to 369)
  AUTHORS   Fleischer,T.C., Weaver,C.M., McAfee,K.J., Jennings,J.L. and
            Link,A.J.
  TITLE     Systematic identification and functional screens of uncharacterized
            proteins associated with eukaryotic ribosomal complexes
  JOURNAL   Genes Dev 20 (10), 1294-1307 (2006)
   PUBMED   16702403
  REMARK    IDENTIFICATION BY MASS SPECTROMETRY, AND INTERACTION WITH RIBOSOMES
            AND TMA46.
REFERENCE   7  (residues 1 to 369)
  AUTHORS   Wout,P.K., Sattlegger,E., Sullivan,S.M. and Maddock,J.R.
  TITLE     Saccharomyces cerevisiae Rbg1 protein and its binding partner Gir2
            interact on Polyribosomes with Gcn1
  JOURNAL   Eukaryot Cell 8 (7), 1061-1071 (2009)
   PUBMED   19448108
  REMARK    FUNCTION, ASSOCIATION WITH POLYRIBOSOMES, AND INTERACTION WITH
            GIR2; TMA46; YAP1 AND YGR250C.
REFERENCE   8  (residues 1 to 369)
  AUTHORS   Van Damme,P., Lasa,M., Polevoda,B., Gazquez,C., Elosegui-Artola,A.,
            Kim,D.S., De Juan-Pardo,E., Demeyer,K., Hole,K., Larrea,E.,
            Timmerman,E., Prieto,J., Arnesen,T., Sherman,F., Gevaert,K. and
            Aldabe,R.
  TITLE     N-terminal acetylome analyses and functional insights of the
            N-terminal acetyltransferase NatB
  JOURNAL   Proc Natl Acad Sci U S A 109 (31), 12449-12454 (2012)
   PUBMED   22814378
  REMARK    ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR
            METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS
            SPECTROMETRY [LARGE SCALE ANALYSIS].
COMMENT     On Apr 26, 2005 this sequence version replaced gi:1077475.
            [FUNCTION] Involved in ribosomal function.
            {ECO:0000269|PubMed:19448108}.
            [SUBUNIT] Associates with translating polyribosomes. Interacts with
            GIR2, TMA46, YAP1 and YGR250C. {ECO:0000269|PubMed:16702403,
            ECO:0000269|PubMed:19448108}.
            [INTERACTION] P39729; Q03768: GIR2; NbExp=3; IntAct=EBI-20651,
            EBI-7618.
            [SUBCELLULAR LOCATION] Cytoplasm {ECO:0000269|PubMed:14562095}.
            [MISCELLANEOUS] Present with 11700 molecules/cell in log phase SD
            medium. {ECO:0000269|PubMed:14562106}.
            [SIMILARITY] Belongs to the TRAFAC class OBG-HflX-like GTPase
            superfamily. OBG GTPase family.
            {ECO:0000255|PROSITE-ProRule:PRU01047}.
FEATURES             Location/Qualifiers
     source          1..369
                     /organism="Saccharomyces cerevisiae S288C"
                     /db_xref="taxon:559292"
     gene            1..369
                     /gene="RBG1"
                     /locus_tag="YAL036C"
                     /gene_synonym="FUN11"
     Protein         1..369
                     /product="Ribosome-interacting GTPase 1"
                     /note="GTP-binding protein RBG1; Genetically interacts
                     with ribosomal genes protein 1"
                     /UniProtKB_evidence="Evidence at protein level"
     Region          1..369
                     /region_name="Rbg1"
                     /note="Ribosome-interacting GTPase RBG1 [Translation,
                     ribosomal structure and biogenesis]; COG1163"
                     /db_xref="CDD:440777"
     Region          2..369
                     /region_name="Mature chain"
                     /note="Ribosome-interacting GTPase 1. /id=PRO_0000205449."
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0007744|PubMed:22814378."
     Region          3..17
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          22..24
                     /region_name="Hydrogen bonded turn"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          25..43
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          47..49
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          56..58
                     /region_name="Hydrogen bonded turn"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          64..71
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          66..292
                     /region_name="Domain"
                     /note="OBG-type G.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01047."
     Region          76..86
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          92..94
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          102..109
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          112..118
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          120..122
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          132..142
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          144..151
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          155..168
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          171..173
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          180..184
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          186..188
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          190..196
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          203..212
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          217..222
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          228..235
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          236..239
                     /region_name="Hydrogen bonded turn"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          241..243
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          245..250
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          252..254
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          257..263
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          269..271
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          274..276
                     /region_name="Hydrogen bonded turn"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          280..291
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          292..368
                     /region_name="Domain"
                     /note="TGS.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01228."
     Region          294..298
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          301..303
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          307..309
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          311..314
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          320..327
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          329..334
                     /region_name="Helical region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          335..342
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          345..352
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
     Region          363..368
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:4A9A."
ORIGIN      
        1 msttvekika iedemartqk nkatsfhlgq lkaklaklrr elltsassgs gggagigfdv
       61 artgvasvgf vgfpsvgkst llskltgtes eaaeyefttl vtvpgviryk gakiqmldlp
      121 giidgakdgr grgkqviava rtcnllfiil dvnkplhhkq iiekelegvg irlnktppdi
      181 likkkekggi sitntvplth lgndeiravm seyrinsaei afrcdatvdd lidvleassr
      241 rympaiyvln kidslsieel ellyripnav pissgqdwnl dellqvmwdr lnlvriytkp
      301 kgqipdftdp vvlrsdrcsv kdfcnqihks lvddfrnalv ygssvkhqpq yvglshiled
      361 edvvtilkk
//
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Protein 3D Structure

Reference sequence information

  • RefSeq protein
    See the reference protein sequence for GTP-binding protein RBG1 (NP_009364.1).

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