LOCUS RBG1_YEAST 369 aa linear PLN 27-NOV-2024
DEFINITION RecName: Full=Ribosome-interacting GTPase 1; AltName:
Full=GTP-binding protein RBG1; AltName: Full=Genetically interacts
with ribosomal genes protein 1.
ACCESSION P39729
VERSION P39729.1
DBSOURCE UniProtKB: locus RBG1_YEAST, accession P39729;
class: standard.
extra accessions:D6VPI1
created: Feb 1, 1995.
sequence updated: Feb 1, 1995.
annotation updated: Nov 27, 2024.
xrefs: U12980.3, AAC04995.1, AY693042.1, AAT93061.1, BK006935.2,
DAA06951.1, S51983, NP_009364.1, 4A9A_A, 4A9A_B
xrefs (non-sequence databases): PDBsum:4A9A, AlphaFoldDB:P39729,
SMR:P39729, BioGRID:31729, DIP:DIP-1750N, IntAct:P39729,
MINT:P39729, STRING:4932.YAL036C, iPTMnet:P39729,
PaxDb:4932-YAL036C, PeptideAtlas:P39729, EnsemblFungi:YAL036C_mRNA,
EnsemblFungi:YAL036C, EnsemblFungi:YAL036C, GeneID:851195,
KEGG:sce:YAL036C, AGR:SGD:S000000034, SGD:S000000034,
VEuPathDB:FungiDB:YAL036C, eggNOG:KOG1487,
GeneTree:ENSGT00940000153340, HOGENOM:CLU_044997_0_0_1,
InParanoid:P39729, OMA:SAKHPGQ, OrthoDB:146471at2759,
BioCyc:YEAST:G3O-28846-MONOMER, BioGRID-ORCS:851195,
EvolutionaryTrace:P39729, PRO:PR:P39729, Proteomes:UP000002311,
RNAct:P39729, GO:0005737, GO:0010494, GO:0005777, GO:0005525,
GO:0003924, GO:0002181, GO:1903833, CDD:cd01896, CDD:cd17230,
FunFam:3.10.20.30:FF:000003, FunFam:3.40.50.300:FF:000740,
Gene3D:3.10.20.30, Gene3D:6.10.140.1070, InterPro:IPR012675,
InterPro:IPR045001, InterPro:IPR031167, InterPro:IPR006073,
InterPro:IPR031662, InterPro:IPR006074, InterPro:IPR027417,
InterPro:IPR005225, InterPro:IPR004095, InterPro:IPR012676,
NCBIfam:TIGR00231, PANTHER:PTHR43127:SF1, PANTHER:PTHR43127,
Pfam:PF01926, Pfam:PF16897, Pfam:PF02824, PRINTS:PR00326,
SUPFAM:SSF52540, SUPFAM:SSF81271, PROSITE:PS51710, PROSITE:PS00905,
PROSITE:PS51880
KEYWORDS 3D-structure; Acetylation; Cytoplasm; GTP-binding;
Nucleotide-binding; Reference proteome.
SOURCE Saccharomyces cerevisiae S288C
ORGANISM Saccharomyces cerevisiae S288C
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
Saccharomyces.
REFERENCE 1 (residues 1 to 369)
AUTHORS Bussey,H., Kaback,D.B., Zhong,W.-W., Vo,D.H., Clark,M.W.,
Fortin,N., Hall,J., Ouellette,B.F.F., Keng,T., Barton,A.B., Su,Y.,
Davies,C.J. and Storms,R.K.
TITLE The nucleotide sequence of chromosome I from Saccharomyces
cerevisiae
JOURNAL Proc Natl Acad Sci U S A 92 (9), 3809-3813 (1995)
PUBMED 7731988
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
STRAIN=ATCC 204508 / S288c
REFERENCE 2 (residues 1 to 369)
AUTHORS Engel,S.R., Dietrich,F.S., Fisk,D.G., Binkley,G., Balakrishnan,R.,
Costanzo,M.C., Dwight,S.S., Hitz,B.C., Karra,K., Nash,R.S.,
Weng,S., Wong,E.D., Lloyd,P., Skrzypek,M.S., Miyasato,S.R.,
Simison,M. and Cherry,J.M.
TITLE The reference genome sequence of Saccharomyces cerevisiae: then and
now
JOURNAL G3 (Bethesda) 4 (3), 389-398 (2014)
PUBMED 24374639
REMARK GENOME REANNOTATION.;
STRAIN=ATCC 204508 / S288c
Publication Status: Online-Only
REFERENCE 3 (residues 1 to 369)
AUTHORS Hu,Y., Rolfs,A., Bhullar,B., Murthy,T.V., Zhu,C., Berger,M.F.,
Camargo,A.A., Kelley,F., McCarron,S., Jepson,D., Richardson,A.,
Raphael,J., Moreira,D., Taycher,E., Zuo,D., Mohr,S., Kane,M.F.,
Williamson,J., Simpson,A., Bulyk,M.L., Harlow,E., Marsischky,G.,
Kolodner,R.D. and LaBaer,J.
TITLE Approaching a complete repository of sequence-verified
protein-encoding clones for Saccharomyces cerevisiae
JOURNAL Genome Res 17 (4), 536-543 (2007)
PUBMED 17322287
REMARK NUCLEOTIDE SEQUENCE [GENOMIC DNA].;
STRAIN=ATCC 204508 / S288c
REFERENCE 4 (residues 1 to 369)
AUTHORS Huh,W.K., Falvo,J.V., Gerke,L.C., Carroll,A.S., Howson,R.W.,
Weissman,J.S. and O'Shea,E.K.
TITLE Global analysis of protein localization in budding yeast
JOURNAL Nature 425 (6959), 686-691 (2003)
PUBMED 14562095
REMARK SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
REFERENCE 5 (residues 1 to 369)
AUTHORS Ghaemmaghami,S., Huh,W.K., Bower,K., Howson,R.W., Belle,A.,
Dephoure,N., O'Shea,E.K. and Weissman,J.S.
TITLE Global analysis of protein expression in yeast
JOURNAL Nature 425 (6959), 737-741 (2003)
PUBMED 14562106
REMARK LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
REFERENCE 6 (residues 1 to 369)
AUTHORS Fleischer,T.C., Weaver,C.M., McAfee,K.J., Jennings,J.L. and
Link,A.J.
TITLE Systematic identification and functional screens of uncharacterized
proteins associated with eukaryotic ribosomal complexes
JOURNAL Genes Dev 20 (10), 1294-1307 (2006)
PUBMED 16702403
REMARK IDENTIFICATION BY MASS SPECTROMETRY, AND INTERACTION WITH RIBOSOMES
AND TMA46.
REFERENCE 7 (residues 1 to 369)
AUTHORS Wout,P.K., Sattlegger,E., Sullivan,S.M. and Maddock,J.R.
TITLE Saccharomyces cerevisiae Rbg1 protein and its binding partner Gir2
interact on Polyribosomes with Gcn1
JOURNAL Eukaryot Cell 8 (7), 1061-1071 (2009)
PUBMED 19448108
REMARK FUNCTION, ASSOCIATION WITH POLYRIBOSOMES, AND INTERACTION WITH
GIR2; TMA46; YAP1 AND YGR250C.
REFERENCE 8 (residues 1 to 369)
AUTHORS Van Damme,P., Lasa,M., Polevoda,B., Gazquez,C., Elosegui-Artola,A.,
Kim,D.S., De Juan-Pardo,E., Demeyer,K., Hole,K., Larrea,E.,
Timmerman,E., Prieto,J., Arnesen,T., Sherman,F., Gevaert,K. and
Aldabe,R.
TITLE N-terminal acetylome analyses and functional insights of the
N-terminal acetyltransferase NatB
JOURNAL Proc Natl Acad Sci U S A 109 (31), 12449-12454 (2012)
PUBMED 22814378
REMARK ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR
METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
COMMENT On Apr 26, 2005 this sequence version replaced gi:1077475.
[FUNCTION] Involved in ribosomal function.
{ECO:0000269|PubMed:19448108}.
[SUBUNIT] Associates with translating polyribosomes. Interacts with
GIR2, TMA46, YAP1 and YGR250C. {ECO:0000269|PubMed:16702403,
ECO:0000269|PubMed:19448108}.
[INTERACTION] P39729; Q03768: GIR2; NbExp=3; IntAct=EBI-20651,
EBI-7618.
[SUBCELLULAR LOCATION] Cytoplasm {ECO:0000269|PubMed:14562095}.
[MISCELLANEOUS] Present with 11700 molecules/cell in log phase SD
medium. {ECO:0000269|PubMed:14562106}.
[SIMILARITY] Belongs to the TRAFAC class OBG-HflX-like GTPase
superfamily. OBG GTPase family.
{ECO:0000255|PROSITE-ProRule:PRU01047}.
FEATURES Location/Qualifiers
source 1..369
/organism="Saccharomyces cerevisiae S288C"
/db_xref="taxon:559292"
gene 1..369
/gene="RBG1"
/locus_tag="YAL036C"
/gene_synonym="FUN11"
Protein 1..369
/product="Ribosome-interacting GTPase 1"
/note="GTP-binding protein RBG1; Genetically interacts
with ribosomal genes protein 1"
/UniProtKB_evidence="Evidence at protein level"
Region 1..369
/region_name="Rbg1"
/note="Ribosome-interacting GTPase RBG1 [Translation,
ribosomal structure and biogenesis]; COG1163"
/db_xref="CDD:440777"
Region 2..369
/region_name="Mature chain"
/note="Ribosome-interacting GTPase 1. /id=PRO_0000205449."
Site 2
/site_type="acetylation"
/note="N-acetylserine.
/evidence=ECO:0007744|PubMed:22814378."
Region 3..17
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 22..24
/region_name="Hydrogen bonded turn"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 25..43
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 47..49
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 56..58
/region_name="Hydrogen bonded turn"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 64..71
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 66..292
/region_name="Domain"
/note="OBG-type G.
/evidence=ECO:0000255|PROSITE-ProRule:PRU01047."
Region 76..86
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 92..94
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 102..109
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 112..118
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 120..122
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 132..142
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 144..151
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 155..168
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 171..173
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 180..184
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 186..188
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 190..196
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 203..212
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 217..222
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 228..235
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 236..239
/region_name="Hydrogen bonded turn"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 241..243
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 245..250
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 252..254
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 257..263
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 269..271
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 274..276
/region_name="Hydrogen bonded turn"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 280..291
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 292..368
/region_name="Domain"
/note="TGS.
/evidence=ECO:0000255|PROSITE-ProRule:PRU01228."
Region 294..298
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 301..303
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 307..309
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 311..314
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 320..327
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 329..334
/region_name="Helical region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 335..342
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 345..352
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:4A9A."
Region 363..368
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:4A9A."
ORIGIN
1 msttvekika iedemartqk nkatsfhlgq lkaklaklrr elltsassgs gggagigfdv
61 artgvasvgf vgfpsvgkst llskltgtes eaaeyefttl vtvpgviryk gakiqmldlp
121 giidgakdgr grgkqviava rtcnllfiil dvnkplhhkq iiekelegvg irlnktppdi
181 likkkekggi sitntvplth lgndeiravm seyrinsaei afrcdatvdd lidvleassr
241 rympaiyvln kidslsieel ellyripnav pissgqdwnl dellqvmwdr lnlvriytkp
301 kgqipdftdp vvlrsdrcsv kdfcnqihks lvddfrnalv ygssvkhqpq yvglshiled
361 edvvtilkk
//