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RecName: Full=Vitellogenin-1; Flags: Precursor

UniProtKB/Swiss-Prot: P55155.2

Identical Proteins FASTA Graphics 

LOCUS       VIT1_CAEEL              1616 aa            linear   INV 27-NOV-2024
DEFINITION  RecName: Full=Vitellogenin-1; Flags: Precursor.
ACCESSION   P55155
VERSION     P55155.2
DBSOURCE    UniProtKB: locus VIT1_CAEEL, accession P55155;
            class: standard.
            created: Oct 1, 1996.
            sequence updated: Nov 1, 1997.
            annotation updated: Nov 27, 2024.
            xrefs: FO080893.2, CCD67565.1, T16600, NP_509305.1
            xrefs (non-sequence databases): AlphaFoldDB:P55155, SMR:P55155,
            BioGRID:45958, IntAct:P55155, STRING:6239.K09F5.2.1,
            GlyCosmos:P55155, iPTMnet:P55155, PaxDb:6239-K09F5.2,
            PeptideAtlas:P55155, EnsemblMetazoa:K09F5.2.1,
            EnsemblMetazoa:K09F5.2.1, EnsemblMetazoa:WBGene00006925,
            UCSC:K09F5.2, AGR:WB:WBGene00006925, WormBase:K09F5.2,
            WormBase:CE04746, eggNOG:KOG4338, GeneTree:ENSGT00530000064273,
            HOGENOM:CLU_003821_0_0_1, InParanoid:P55155, OMA:CTPYSEA,
            OrthoDB:3076121at2759, PhylomeDB:P55155, PRO:PR:P55155,
            Proteomes:UP000001940, Bgee:WBGene00006925, GO:0005576, GO:0005319,
            GO:0045735, FunFam:1.25.10.20:FF:000003,
            FunFam:2.30.230.10:FF:000004, FunFam:2.20.80.10:FF:000004,
            Gene3D:2.20.80.10, Gene3D:1.25.10.20, InterPro:IPR015819,
            InterPro:IPR011030, InterPro:IPR015816, InterPro:IPR015255,
            InterPro:IPR050733, InterPro:IPR001747, InterPro:IPR001846,
            PANTHER:PTHR23345:SF12, PANTHER:PTHR23345, Pfam:PF09172,
            Pfam:PF01347, Pfam:PF00094, SMART:SM01169, SMART:SM00638,
            SMART:SM00216, SUPFAM:SSF48431, PROSITE:PS51211, PROSITE:PS51233
KEYWORDS    Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal;
            Storage protein.
SOURCE      Caenorhabditis elegans
  ORGANISM  Caenorhabditis elegans
            Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
            Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
            Caenorhabditis.
REFERENCE   1  (residues 1 to 1616)
  CONSRTM   C. elegans Sequencing Consortium
  TITLE     Genome sequence of the nematode C. elegans: a platform for
            investigating biology
  JOURNAL   Science 282 (5396), 2012-2018 (1998)
   PUBMED   9851916
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
            STRAIN=Bristol N2
            Erratum:[Science 1999 Jan 1;283(5398):35]
REFERENCE   2  (residues 1 to 1616)
  AUTHORS   Kaji,H., Kamiie,J., Kawakami,H., Kido,K., Yamauchi,Y., Shinkawa,T.,
            Taoka,M., Takahashi,N. and Isobe,T.
  TITLE     Proteomics reveals N-linked glycoprotein diversity in
            Caenorhabditis elegans and suggests an atypical translocation
            mechanism for integral membrane proteins
  JOURNAL   Mol Cell Proteomics 6 (12), 2100-2109 (2007)
   PUBMED   17761667
  REMARK    GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1270, AND
            IDENTIFICATION BY MASS SPECTROMETRY.;
            STRAIN=Bristol N2
REFERENCE   3  (residues 1 to 1616)
  AUTHORS   Seah,N.E., de Magalhaes Filho,C.D., Petrashen,A.P., Henderson,H.R.,
            Laguer,J., Gonzalez,J., Dillin,A., Hansen,M. and Lapierre,L.R.
  TITLE     Autophagy-mediated longevity is modulated by lipoprotein biogenesis
  JOURNAL   Autophagy 12 (2), 261-272 (2016)
   PUBMED   26671266
  REMARK    FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
            PHENOTYPE.
COMMENT     On or before Jun 21, 2005 this sequence version replaced
            gi:7442002, gi:1722701.
            [FUNCTION] Precursor of the egg-yolk proteins that are sources of
            nutrients during embryonic development (Probable). Together with
            other vitellogenins, may play a role in modulating life-span,
            acting via induction of autophagy and lysosomal lipolysis
            (PubMed:26671266). {ECO:0000269|PubMed:26671266, ECO:0000305}.
            [SUBCELLULAR LOCATION] Secreted {ECO:0000305|PubMed:26671266}.
            [TISSUE SPECIFICITY] Expressed in the intestine of adult
            hermaphrodites. {ECO:0000305|PubMed:26671266}.
            [DISRUPTION PHENOTYPE] Simultaneous RNAi-mediated knockdown of
            vitellogenins vit-1, vit-2, vit-3, vit-4 and vit-5 increases life
            span, causes accumulation of neutral lipid and an increase in lgg-1
            foci in the proximal intestine; however, does not affect fertility
            or pharyngeal pumping rates (PubMed:26671266). Expression of
            transcription factors pha-4 and daf-16 are increased
            (PubMed:26671266). {ECO:0000269|PubMed:26671266}.
            [CAUTION] High sequence similarity with other vitellogenin genes
            means that assigning functions to individual proteins is difficult;
            authors sometimes refer to VITs or vitellogenins.
            {ECO:0000305|PubMed:26671266}.
FEATURES             Location/Qualifiers
     source          1..1616
                     /organism="Caenorhabditis elegans"
                     /db_xref="taxon:6239"
     gene            1..1616
                     /gene="vit-1"
                     /locus_tag="K09F5.2"
     Protein         1..1616
                     /product="Vitellogenin-1"
                     /UniProtKB_evidence="Evidence at protein level"
     Region          1..19
                     /region_name="Signal"
                     /note="/evidence=ECO:0000255."
     Region          20..1616
                     /region_name="Mature chain"
                     /note="Vitellogenin-1. /id=PRO_0000041532."
     Region          24..689
                     /region_name="Domain"
                     /note="Vitellogenin.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00557."
     Region          24..620
                     /region_name="Vitellogenin_N"
                     /note="Lipoprotein amino terminal region; pfam01347"
                     /db_xref="CDD:460170"
     Region          655..939
                     /region_name="Vit_open_b-sht"
                     /note="Vitellinogen, open beta-sheet; pfam09172"
                     /db_xref="CDD:462702"
     Site            1270
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:17761667."
     Region          1301..1458
                     /region_name="VWD"
                     /note="von Willebrand factor (vWF) type D domain;
                     smart00216"
                     /db_xref="CDD:214566"
     Region          1310..1479
                     /region_name="Domain"
                     /note="VWFD.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00580."
     Bond            bond(1312,1442)
                     /bond_type="disulfide"
                     /note="/evidence=ECO:0000255|PROSITE-ProRule:PRU00580."
     Bond            bond(1334,1478)
                     /bond_type="disulfide"
                     /note="/evidence=ECO:0000255|PROSITE-ProRule:PRU00580."
     Region          1505..1531
                     /region_name="Region of interest in the sequence"
                     /note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
     Region          1512..1531
                     /region_name="Compositionally biased region"
                     /note="Basic and acidic residues.
                     /evidence=ECO:0000256|SAM:MobiDB-lite."
ORIGIN      
        1 mrsiiiasiv alaiafspaf ertfepkidy hykfdglvls glptassels qsrfsarvri
       61 qavddrhihl qlvnihmaas hlpeseqips lnsmeqrels eeykqmlklp lraqlrngli
      121 aelqfdkeda ewsknmkrav vnmisfnpia prneiekies sydkeeqsee ntsfftnekt
      181 legdcqvayt vireqkktii tksinfdkct erseiayglr yssecpecek dtvlirpqtv
      241 ytyileneel kesevrslyt vnvngqevmk tetrsklvle enhsikshie kvngekesii
      301 yssrweqlve dffkngdkae fapfekfpld kkmhliktit eqiqevenni petshflarl
      361 vrifrttsts qlkeihetly vkadkkiqsl mehalaiagt kntiqhilvh ienedivple
      421 aaqllksiqe tpfpsqtiae alikfaesrv sknnqvvrqs awlaagsvvr givdyknirp
      481 lvredkrelk ekflrvfmqq ykdaettyek ilalksigna gldisvnqln eiivdkrqll
      541 pvrkeaidal rllkdtmprk iqkvllpiyk nrqyepeirm lalwrmmhtr peesllvqvv
      601 sqmeketnqq vaalthqmir hfakstnpcy qrvaivcskv lsftryqpqe qmiassyaql
      661 plflqnsfsg aqfdfaaife knsfllkdlh asldavfggn wnkyfaqigf sqqhmdkyvq
      721 maleklesie kesttvvrgr riqtgitllk elalkmnira rpanynekda famvylrykd
      781 mdyailpvdt qlieklieky isngkvqfse irrllnqehe fethhaayfy eairkfpttl
      841 glplivsgki ptvfsaegqf slgleetelr ltvearpsva athvyemrmf tplfeqgvks
      901 vqsvraytpi kiqavvgmkr nfeivykvvv penqksiisl ttrpvvflrf pgfskfeyie
      961 aeertvvvpq wqqktqeiek vfnflglevs trgnilnqht lenwllaeqd fevsvenkyr
     1021 paeftarltv gqlektelsq ikynkifeke feleqentes rreyftkmvk siqkeqgyks
     1081 vvslrleapr dytmntevtt vcdkqvrmcq weveirrspi leetkewtlr sqllvvrpem
     1141 psslrqlhdq phrevqlslt stwgsqkkse vtvnaqlqqs keqkkyernm drhfngmpey
     1201 ellikaarln qinavaeykl treteqvlar yfdlvkayny wtvssrpenn endrvvvqlt
     1261 vepmsrqyvn itmqspierv elknvqvprv ylpsiaqrsv khllneasgs vckvqknqir
     1321 tfddvlyntp lttcysliak dcseeptfav lskkteknse emiikvirge qeivaqlqne
     1381 eirvkvdgkk ilsedysahq ierlgesdiv ielpegevrf dgytiktqlp sysrknqlcg
     1441 lcgnnddest nefytsdnte tkdieefhrs yllkneecea eeerlsekkn yrkyderkye
     1501 seeysfeety dyeqentnkk qknqrsqkks dlvektqike fshricfsve pvaecrrrgy
     1561 eaveqqqrkv rftclprhss earrlvkear qgtvqlddhk isfvhsvqvp vacvay
//
Feature
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Reference sequence information

  • RefSeq protein
    See the reference protein sequence for Vitellogenin-1 (NP_001367671.1).

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