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RecName: Full=tRNA pseudouridine synthase B; AltName: Full=tRNA pseudouridine(55) synthase; Short=Psi55 synthase; AltName: Full=tRNA pseudouridylate synthase; AltName: Full=tRNA-uridine isomerase

UniProtKB/Swiss-Prot: Q0T0B5.1

Identical Proteins FASTA Graphics 

LOCUS       TRUB_SHIF8               314 aa            linear   BCT 27-NOV-2024
DEFINITION  RecName: Full=tRNA pseudouridine synthase B; AltName: Full=tRNA
            pseudouridine(55) synthase; Short=Psi55 synthase; AltName:
            Full=tRNA pseudouridylate synthase; AltName: Full=tRNA-uridine
            isomerase.
ACCESSION   Q0T0B5
VERSION     Q0T0B5.1
DBSOURCE    UniProtKB: locus TRUB_SHIF8, accession Q0T0B5;
            class: standard.
            created: May 20, 2008.
            sequence updated: Sep 5, 2006.
            annotation updated: Nov 27, 2024.
            xrefs: CP000266.1, ABF05250.1, WP_000089698.1
            xrefs (non-sequence databases): AlphaFoldDB:Q0T0B5, SMR:Q0T0B5,
            GeneID:75173340, KEGG:sfv:SFV_3196, HOGENOM:CLU_032087_0_3_6,
            Proteomes:UP000000659, GO:0003723, GO:0160148, GO:1990481,
            GO:0031119, CDD:cd02573, CDD:cd21152, FunFam:2.30.130.10:FF:000004,
            FunFam:3.30.2350.10:FF:000003, Gene3D:3.30.2350.10,
            Gene3D:2.30.130.10, HAMAP:MF_01080, InterPro:IPR020103,
            InterPro:IPR002501, InterPro:IPR015947, InterPro:IPR036974,
            InterPro:IPR014780, InterPro:IPR015240, InterPro:IPR032819,
            NCBIfam:TIGR00431, PANTHER:PTHR13767:SF2, PANTHER:PTHR13767,
            Pfam:PF09157, Pfam:PF16198, Pfam:PF01509, SUPFAM:SSF55120,
            SUPFAM:SSF88697
KEYWORDS    Isomerase; tRNA processing.
SOURCE      Shigella flexneri 5 str. 8401
  ORGANISM  Shigella flexneri 5 str. 8401
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Shigella.
REFERENCE   1  (residues 1 to 314)
  AUTHORS   Nie,H., Yang,F., Zhang,X., Yang,J., Chen,L., Wang,J., Xiong,Z.,
            Peng,J., Sun,L., Dong,J., Xue,Y., Xu,X., Chen,S., Yao,Z., Shen,Y.
            and Jin,Q.
  TITLE     Complete genome sequence of Shigella flexneri 5b and comparison
            with Shigella flexneri 2a
  JOURNAL   BMC Genomics 7, 173 (2006)
   PUBMED   16822325
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
            STRAIN=8401
            Publication Status: Online-Only
COMMENT     [FUNCTION] Responsible for synthesis of pseudouridine from
            uracil-55 in the psi GC loop of transfer RNAs.
            {ECO:0000255|HAMAP-Rule:MF_01080}.
            [CATALYTIC ACTIVITY] Reaction=uridine(55) in tRNA =
            pseudouridine(55) in tRNA; Xref=Rhea:RHEA:42532,
            Rhea:RHEA-COMP:10101, Rhea:RHEA-COMP:10102, ChEBI:CHEBI:65314,
            ChEBI:CHEBI:65315; EC=5.4.99.25;
            Evidence={ECO:0000255|HAMAP-Rule:MF_01080}.
            [SIMILARITY] Belongs to the pseudouridine synthase TruB family.
            Type 1 subfamily. {ECO:0000255|HAMAP-Rule:MF_01080}.
FEATURES             Location/Qualifiers
     source          1..314
                     /organism="Shigella flexneri 5 str. 8401"
                     /db_xref="taxon:373384"
     gene            1..314
                     /gene="truB"
                     /locus_tag="SFV_3196"
     Protein         1..314
                     /product="tRNA pseudouridine synthase B"
                     /EC_number="5.4.99.25"
                     /note="tRNA pseudouridine(55) synthase; tRNA
                     pseudouridylate synthase; tRNA-uridine isomerase; Psi55
                     synthase"
                     /UniProtKB_evidence="Inferred from homology"
     Region          1..314
                     /region_name="Mature chain"
                     /note="tRNA pseudouridine synthase B. /id=PRO_1000084683."
     Region          13..311
                     /region_name="TruB"
                     /note="tRNA U55 pseudouridine synthase TruB, may also work
                     on U342 of tmRNA [Translation, ribosomal structure and
                     biogenesis]; COG0130"
                     /db_xref="CDD:439900"
     Site            48
                     /site_type="active"
                     /note="Nucleophile.
                     /evidence=ECO:0000255|HAMAP-Rule:MF_01080."
ORIGIN      
        1 msrprrrgrd ingvllldkp qgmssndalq kvkriynanr aghtgaldpl atgmlpiclg
       61 eatkfsqyll dsdkryrvia rlgqrtdtsd adgqiveerp vtfsaeqlaa aldtfrgdie
      121 qipsmysalk yqgkklyeya rqgievprea rpitvyellf irhegnelel eihcskgtyi
      181 rtiiddlgek lgcgahviyl rrlavskypv ermvtlehlr elveqaeqqd ipaaelldpl
      241 lmpmdspasd ypvvnlplts svyfkngnpv rtsgaplegl vrvtegengk figmgeidde
      301 grvaprrlvv eypa
//
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