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UniProtKB/Swiss-Prot: Q35675.2
Identical Proteins FASTA Graphics
LOCUS CYB_PLATE 381 aa linear MAM 27-NOV-2024 DEFINITION RecName: Full=Cytochrome b; AltName: Full=Complex III subunit 3; AltName: Full=Complex III subunit III; AltName: Full=Cytochrome b-c1 complex subunit 3; AltName: Full=Ubiquinol-cytochrome-c reductase complex cytochrome b subunit. ACCESSION Q35675 VERSION Q35675.2 DBSOURCE UniProtKB: locus CYB_PLATE, accession Q35675; class: standard. created: Jul 15, 1998. sequence updated: Jun 1, 1998. annotation updated: Nov 27, 2024. xrefs: U07591.1, AAB88767.1 xrefs (non-sequence databases): AlphaFoldDB:Q35675, SMR:Q35675, GO:0005743, GO:0045275, GO:0046872, GO:0008121, GO:0006122, CDD:cd00290, CDD:cd00284, FunFam:1.20.810.10:FF:000002, InterPro:IPR005798, InterPro:IPR036150, InterPro:IPR005797, InterPro:IPR027387, InterPro:IPR030689, InterPro:IPR048260, InterPro:IPR048259, InterPro:IPR016174, PANTHER:PTHR19271, PANTHER:PTHR19271:SF16, Pfam:PF00032, Pfam:PF00033, PIRSF:PIRSF038885, SUPFAM:SSF81648, SUPFAM:SSF81342, PROSITE:PS51003, PROSITE:PS51002 KEYWORDS Electron transport; Heme; Iron; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Respiratory chain; Transmembrane; Transmembrane helix; Transport; Ubiquinone. SOURCE mitochondrion Planigale tenuirostris (flat-skulled marsupial mouse) ORGANISM Planigale tenuirostris Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Planigale. REFERENCE 1 (residues 1 to 381) AUTHORS Krajewski,C., Blacket,M., Buckley,L. and Westerman,M. TITLE A multigene assessment of phylogenetic relationships within the dasyurid marsupial subfamily Sminthopsinae JOURNAL Mol Phylogenet Evol 8 (2), 236-248 (1997) PUBMED 9299228 REMARK NUCLEOTIDE SEQUENCE [GENOMIC DNA]. COMMENT [FUNCTION] Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. {ECO:0000250|UniProtKB:P00157}. [COFACTOR] Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence={ECO:0000250|UniProtKB:P00157}; Note=Binds 2 heme b groups non-covalently. {ECO:0000250|UniProtKB:P00157}. [SUBUNIT] The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer. {ECO:0000250|UniProtKB:P00157}. [SUBCELLULAR LOCATION] Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00157}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P00157}. [MISCELLANEOUS] Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm. {ECO:0000250}. [SIMILARITY] Belongs to the cytochrome b family. {ECO:0000255|PROSITE-ProRule:PRU00967, ECO:0000255|PROSITE-ProRule:PRU00968}. [CAUTION] The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools. {ECO:0000250|UniProtKB:P00157}. FEATURES Location/Qualifiers source 1..381 /organism="Planigale tenuirostris" /organelle="mitochondrion" /db_xref="taxon:32557" gene 1..381 /gene="MT-CYB" /gene_synonym="COB" /gene_synonym="CYTB" /gene_synonym="MTCYB" Protein 1..381 /product="Cytochrome b" /note="Complex III subunit 3; Complex III subunit III; Cytochrome b-c1 complex subunit 3; Ubiquinol-cytochrome-c reductase complex cytochrome b subunit" /UniProtKB_evidence="Inferred from homology" Region 1..381 /region_name="Mature chain" /note="Cytochrome b. /id=PRO_0000061416." Region 1..378 /region_name="CYTB" /note="cytochrome b; Provisional; MTH00100" /db_xref="CDD:177162" Region 33..53 /region_name="Transmembrane region" /note="Helical. /evidence=ECO:0000250|UniProtKB:P00157." Region 77..98 /region_name="Transmembrane region" /note="Helical. /evidence=ECO:0000250|UniProtKB:P00157." Region 113..133 /region_name="Transmembrane region" /note="Helical. /evidence=ECO:0000250|UniProtKB:P00157." Region 178..198 /region_name="Transmembrane region" /note="Helical. /evidence=ECO:0000250|UniProtKB:P00157." Region 226..246 /region_name="Transmembrane region" /note="Helical. /evidence=ECO:0000250|UniProtKB:P00157." Region 288..308 /region_name="Transmembrane region" /note="Helical. /evidence=ECO:0000250|UniProtKB:P00157." Region 320..340 /region_name="Transmembrane region" /note="Helical. /evidence=ECO:0000250|UniProtKB:P00157." Region 347..367 /region_name="Transmembrane region" /note="Helical. /evidence=ECO:0000250|UniProtKB:P00157." ORIGIN 1 mtnlrkthpl mkivnhsfid lpapsnisaw wnfgsllgic lviqiltglf lamhytsdtl 61 tafssvahic rdvnygwlir nlhangasmf fmclflhvgr giyygsylyk etwnigvill 121 ltvmatafvg yvlpwgqmsf wgatvitnll saipyvgttl aewiwggfav dkatltrffa 181 fhfilpfiit alvivhllfl hetgsnnpsg inpdsdkipf hpyytikdal glmfllltll 241 llalfspdsl gdpdnfspan plntpphikp ewyflfayai lrsipnklgg vlallasili 301 llvipflhta nqrsmmfrpi sqtlfwilsa nlitltwigg qpveqpfiii gqlasilyfl 361 lilvlmplag lfenymlkpk w //
Whole sequence Selected region from: to:
Conserved Domains
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