LOCUS EMAL5_RAT 1977 aa linear ROD 27-NOV-2024
DEFINITION RecName: Full=Echinoderm microtubule-associated protein-like 5;
Short=EMAP-5; Short=EMAP-like protein 5.
ACCESSION Q6ED65
VERSION Q6ED65.2
DBSOURCE UniProtKB: locus EMAL5_RAT, accession Q6ED65;
class: standard.
created: Apr 17, 2007.
sequence updated: Apr 17, 2007.
annotation updated: Nov 27, 2024.
xrefs: AY445136.1, AAS01608.1, AABR03048720.1, AABR03052861.1,
AABR03050388.1, AABR03049430.1
xrefs (non-sequence databases): AlphaFoldDB:Q6ED65, SMR:Q6ED65,
STRING:10116.ENSRNOP00000054411, CarbonylDB:Q6ED65, iPTMnet:Q6ED65,
PhosphoSitePlus:Q6ED65, PaxDb:10116-ENSRNOP00000054411,
UCSC:RGD:1303275, AGR:RGD:1303275, RGD:1303275, eggNOG:KOG2106,
InParanoid:Q6ED65, PhylomeDB:Q6ED65, PRO:PR:Q6ED65,
Proteomes:UP000002494, GO:0005737, GO:0005874, GO:0008017,
FunFam:2.130.10.10:FF:000040, FunFam:2.130.10.10:FF:000042,
FunFam:2.130.10.10:FF:000044, FunFam:2.130.10.10:FF:000024,
FunFam:2.130.10.10:FF:000035, FunFam:2.130.10.10:FF:000037,
Gene3D:2.130.10.10, InterPro:IPR024977, InterPro:IPR005108,
InterPro:IPR011047, InterPro:IPR015943, InterPro:IPR019775,
InterPro:IPR036322, InterPro:IPR001680, InterPro:IPR050630,
PANTHER:PTHR13720:SF16, PANTHER:PTHR13720, Pfam:PF12894,
Pfam:PF03451, Pfam:PF00400, SMART:SM00320, SUPFAM:SSF101898,
SUPFAM:SSF50998, SUPFAM:SSF50960, SUPFAM:SSF50978, PROSITE:PS00678,
PROSITE:PS50082, PROSITE:PS50294
KEYWORDS Alternative splicing; Cytoplasm; Cytoskeleton; Microtubule;
Reference proteome; Repeat; WD repeat.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (residues 1 to 1977)
AUTHORS O'Connor,V., Houtman,S.H., De Zeeuw,C.I., Bliss,T.V. and
French,P.J.
TITLE Eml5, a novel WD40 domain protein expressed in rat brain
JOURNAL Gene 336 (1), 127-137 (2004)
PUBMED 15225882
REMARK NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY,
DEVELOPMENTAL STAGE, AND ALTERNATIVE SPLICING.
REFERENCE 2 (residues 1 to 1977)
AUTHORS Gibbs,R.A., Weinstock,G.M., Metzker,M.L., Muzny,D.M.,
Sodergren,E.J., Scherer,S., Scott,G., Steffen,D., Worley,K.C.,
Burch,P.E., Okwuonu,G., Hines,S., Lewis,L., DeRamo,C., Delgado,O.,
Dugan-Rocha,S., Miner,G., Morgan,M., Hawes,A., Gill,R., Celera,
Holt,R.A., Adams,M.D., Amanatides,P.G., Baden-Tillson,H.,
Barnstead,M., Chin,S., Evans,C.A., Ferriera,S., Fosler,C.,
Glodek,A., Gu,Z., Jennings,D., Kraft,C.L., Nguyen,T.,
Pfannkoch,C.M., Sitter,C., Sutton,G.G., Venter,J.C., Woodage,T.,
Smith,D., Lee,H.M., Gustafson,E., Cahill,P., Kana,A.,
Doucette-Stamm,L., Weinstock,K., Fechtel,K., Weiss,R.B., Dunn,D.M.,
Green,E.D., Blakesley,R.W., Bouffard,G.G., De Jong,P.J.,
Osoegawa,K., Zhu,B., Marra,M., Schein,J., Bosdet,I., Fjell,C.,
Jones,S., Krzywinski,M., Mathewson,C., Siddiqui,A., Wye,N.,
McPherson,J., Zhao,S., Fraser,C.M., Shetty,J., Shatsman,S.,
Geer,K., Chen,Y., Abramzon,S., Nierman,W.C., Havlak,P.H., Chen,R.,
Durbin,K.J., Simons,R., Ren,Y., Song,X.Z., Li,B., Liu,Y., Qin,X.,
Cawley,S., Worley,K.C., Cooney,A.J., D'Souza,L.M., Martin,K.,
Wu,J.Q., Gonzalez-Garay,M.L., Jackson,A.R., Kalafus,K.J.,
McLeod,M.P., Milosavljevic,A., Virk,D., Volkov,A., Wheeler,D.A.,
Zhang,Z., Bailey,J.A., Eichler,E.E., Tuzun,E., Birney,E.,
Mongin,E., Ureta-Vidal,A., Woodwark,C., Zdobnov,E., Bork,P.,
Suyama,M., Torrents,D., Alexandersson,M., Trask,B.J., Young,J.M.,
Huang,H., Wang,H., Xing,H., Daniels,S., Gietzen,D., Schmidt,J.,
Stevens,K., Vitt,U., Wingrove,J., Camara,F., Mar Alba,M.,
Abril,J.F., Guigo,R., Smit,A., Dubchak,I., Rubin,E.M., Couronne,O.,
Poliakov,A., Hubner,N., Ganten,D., Goesele,C., Hummel,O.,
Kreitler,T., Lee,Y.A., Monti,J., Schulz,H., Zimdahl,H.,
Himmelbauer,H., Lehrach,H., Jacob,H.J., Bromberg,S.,
Gullings-Handley,J., Jensen-Seaman,M.I., Kwitek,A.E., Lazar,J.,
Pasko,D., Tonellato,P.J., Twigger,S., Ponting,C.P., Duarte,J.M.,
Rice,S., Goodstadt,L., Beatson,S.A., Emes,R.D., Winter,E.E.,
Webber,C., Brandt,P., Nyakatura,G., Adetobi,M., Chiaromonte,F.,
Elnitski,L., Eswara,P., Hardison,R.C., Hou,M., Kolbe,D., Makova,K.,
Miller,W., Nekrutenko,A., Riemer,C., Schwartz,S., Taylor,J.,
Yang,S., Zhang,Y., Lindpaintner,K., Andrews,T.D., Caccamo,M.,
Clamp,M., Clarke,L., Curwen,V., Durbin,R., Eyras,E., Searle,S.M.,
Cooper,G.M., Batzoglou,S., Brudno,M., Sidow,A., Stone,E.A.,
Venter,J.C., Payseur,B.A., Bourque,G., Lopez-Otin,C., Puente,X.S.,
Chakrabarti,K., Chatterji,S., Dewey,C., Pachter,L., Bray,N.,
Yap,V.B., Caspi,A., Tesler,G., Pevzner,P.A., Haussler,D.,
Roskin,K.M., Baertsch,R., Clawson,H., Furey,T.S., Hinrichs,A.S.,
Karolchik,D., Kent,W.J., Rosenbloom,K.R., Trumbower,H.,
Weirauch,M., Cooper,D.N., Stenson,P.D., Ma,B., Brent,M.,
Arumugam,M., Shteynberg,D., Copley,R.R., Taylor,M.S., Riethman,H.,
Mudunuri,U., Peterson,J., Guyer,M., Felsenfeld,A., Old,S.,
Mockrin,S. and Collins,F.
CONSRTM Rat Genome Sequencing Project Consortium
TITLE Genome sequence of the Brown Norway rat yields insights into
mammalian evolution
JOURNAL Nature 428 (6982), 493-521 (2004)
PUBMED 15057822
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
STRAIN=Brown Norway
COMMENT On Apr 20, 2007 this sequence version replaced gi:81910935.
[FUNCTION] May modify the assembly dynamics of microtubules, such
that microtubules are slightly longer, but more dynamic.
{ECO:0000250}.
[SUBCELLULAR LOCATION] Cytoplasm, cytoskeleton {ECO:0000305}.
[ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named
isoforms=4; Name=1; IsoId=Q6ED65-1; Sequence=Displayed; Name=2;
IsoId=Q6ED65-2; Sequence=VSP_024492, VSP_024493; Name=3;
IsoId=Q6ED65-3; Sequence=VSP_024490; Name=4; IsoId=Q6ED65-4;
Sequence=VSP_024491.
[TISSUE SPECIFICITY] Highly expressed in brain, especially in
hippocampus, cerebellum and olfactory bulb (at protein level).
{ECO:0000269|PubMed:15225882}.
[DEVELOPMENTAL STAGE] Expressed in fore- and hindbrain structures
from 13 dpc onwards. {ECO:0000269|PubMed:15225882}.
[SIMILARITY] Belongs to the WD repeat EMAP family. {ECO:0000305}.
FEATURES Location/Qualifiers
source 1..1977
/organism="Rattus norvegicus"
/db_xref="taxon:10116"
gene 1..1977
/gene="Eml5"
Protein 1..1977
/product="Echinoderm microtubule-associated protein-like
5"
/note="EMAP-5; EMAP-like protein 5"
/UniProtKB_evidence="Evidence at protein level"
Region 1..1977
/region_name="Mature chain"
/note="Echinoderm microtubule-associated protein-like 5.
/id=PRO_0000284397."
Region <2..49
/region_name="HELP"
/note="HELP motif; pfam03451"
/db_xref="CDD:460922"
Region 58..438
/region_name="WD40"
/note="WD40 repeat [General function prediction only];
COG2319"
/db_xref="CDD:441893"
Region 59..100
/region_name="Repetitive region"
/note="WD 1."
Region 64..104
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 104..145
/region_name="Repetitive region"
/note="WD 2."
Region 110..148
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 148..187
/region_name="Repetitive region"
/note="WD 3."
Region 153..201
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 195..233
/region_name="Repetitive region"
/note="WD 4."
Region 203..233
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 235..273
/region_name="Repetitive region"
/note="WD 5."
Region 240..273
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 280..321
/region_name="Repetitive region"
/note="WD 6."
Region 286..321
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 321..592
/region_name="WD40"
/note="WD40 domain, found in a number of eukaryotic
proteins that cover a wide variety of functions including
adaptor/regulatory modules in signal transduction,
pre-mRNA processing and cytoskeleton assembly; typically
contains a GH dipeptide 11-24 residues from...; cl29593"
/db_xref="CDD:475233"
Site order(323,342,346,352..353,364..365,383,387,393..394,
406..407,424,429,435..436,450,467,470,478..479,508..509,
534,539,545..546,561..562,580,585,591..592)
/site_type="active"
/note="structural tetrad [active]"
/db_xref="CDD:238121"
Region 323..362
/region_name="Repetitive region"
/note="WD 7."
Region 328..352
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 364..403
/region_name="Repetitive region"
/note="WD 8."
Region 369..401
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 406..445
/region_name="Repetitive region"
/note="WD 9."
Region 411..451
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 449..488
/region_name="Repetitive region"
/note="WD 10."
Region 522..560
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 561..601
/region_name="Repetitive region"
/note="WD 11."
Region 609..629
/region_name="Region of interest in the sequence"
/note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
Region 615..629
/region_name="Compositionally biased region"
/note="Acidic residues.
/evidence=ECO:0000256|SAM:MobiDB-lite."
Region <672..715
/region_name="HELP"
/note="HELP motif; pfam03451"
/db_xref="CDD:460922"
Region 720..1140
/region_name="WD40"
/note="WD40 repeat [General function prediction only];
COG2319"
/db_xref="CDD:441893"
Region 725..766
/region_name="Repetitive region"
/note="WD 12."
Region 730..769
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 770..811
/region_name="Repetitive region"
/note="WD 13."
Region 775..852
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 814..853
/region_name="Repetitive region"
/note="WD 14."
Region 857..900
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 861..900
/region_name="Repetitive region"
/note="WD 15."
Region 901..940
/region_name="Repetitive region"
/note="WD 16."
Region 907..994
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 941..992
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 996..1035
/region_name="Repetitive region"
/note="WD 17."
Region 1001..1035
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 1038..1077
/region_name="Repetitive region"
/note="WD 18."
Region 1043..1069
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 1080..1120
/region_name="Repetitive region"
/note="WD 19."
Region 1085..1110
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 1128..1166
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 1167..1977
/region_name="Splicing variant"
/note="Missing (in isoform 3). /evidence=ECO:0000305.
/id=VSP_024490."
Region 1178..1236
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 1236..1276
/region_name="Repetitive region"
/note="WD 20."
Region 1241..1266
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 1274..1299
/region_name="Region of interest in the sequence"
/note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
Region 1323..1363
/region_name="Region of interest in the sequence"
/note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
Region 1336..1977
/region_name="Splicing variant"
/note="Missing (in isoform 4). /evidence=ECO:0000305.
/id=VSP_024491."
Region <1363..1410
/region_name="HELP"
/note="HELP motif; pfam03451"
/db_xref="CDD:460922"
Region 1420..1471
/region_name="Repetitive region"
/note="WD 21."
Region 1426..1475
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 1428..1815
/region_name="WD40"
/note="WD40 repeat [General function prediction only];
COG2319"
/db_xref="CDD:441893"
Region 1475..1516
/region_name="Repetitive region"
/note="WD 22."
Region 1480..1518
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 1519..1558
/region_name="Repetitive region"
/note="WD 23."
Region 1525..1566
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 1568..1606
/region_name="Repetitive region"
/note="WD 24."
Region 1573..1605
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 1581..1605
/region_name="Splicing variant"
/note="NNLTFTGTISGDVCVWKDHILCRVV ->
VCLLKCCVMCDLECVLPYIHKQHEY (in isoform 2).
/evidence=ECO:0000303|PubMed:15225882. /id=VSP_024492."
Region 1606..1977
/region_name="Splicing variant"
/note="Missing (in isoform 2).
/evidence=ECO:0000303|PubMed:15225882. /id=VSP_024493."
Region 1608..1654
/region_name="Repetitive region"
/note="WD 25."
Region 1613..1676
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 1697..1970
/region_name="WD40"
/note="WD40 domain, found in a number of eukaryotic
proteins that cover a wide variety of functions including
adaptor/regulatory modules in signal transduction,
pre-mRNA processing and cytoskeleton assembly; typically
contains a GH dipeptide 11-24 residues from...; cl29593"
/db_xref="CDD:475233"
Region 1699..1739
/region_name="Repetitive region"
/note="WD 26."
Region 1705..1743
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 1741..1782
/region_name="Repetitive region"
/note="WD 27."
Region 1783..1822
/region_name="Repetitive region"
/note="WD 28."
Region 1788..1821
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 1834..1892
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 1895..1934
/region_name="Repetitive region"
/note="WD 29."
Region 1900..1939
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 1940..1977
/region_name="Repetitive region"
/note="WD 30."
ORIGIN
1 maarsapsch lrlewvygyr ghqcrnnlyy taakeivyfv agvgvvyspr ehrqkfyrgh
61 sddiislalh pervlvatgq vgkepyicvw dsytvqtvsv lkdvhthgia clafdldgqr
121 lvsvgldskn avcvwdwkrg kmlsmapght drifdiswdl yqpnklvscg vkhikfwslc
181 gnaltpkrgv fgktgdlqti lclacardel tysgalngdi yvwkginlir tiqgahtagi
241 fsmnaceegf atggrdgcir lwdltfkpit vidlreteqg ykglsvrsvc wrgdhilvgt
301 qdseifeivv hernkpflim qghcegelwa lavhptkpla vtgsddrsvr iwslvdhali
361 arcnmdepir caavnadgvh lalgmkdgsl tvlrvrdmte vvhikdrkea ihelkyspdg
421 tylavgcnds svdiygvaqr ykkvgecvgs lsfithldws sdskylqtnd gsgkrllykm
481 pggkevtske evkgmhwasw tcvaglevng iwpkysdind insvdgnyvg qvlvtaddyg
541 vvklfrypcl rkgakfrkyi ghsahvtnvr wshdyqwvis iggadhsvfq wkfiperklk
601 dalhiapqes ltesnsdesd sdlsdvpeld seieqetqlt yhrqvykedl pqlkeqckek
661 qksatskrre rapgnsirlh fihgyrgydc rsnlfytqig eivyhvaavg viynrqqntq
721 rfylghdddi lclaihplkd yvatgqvgrd psihvwdtet ikplsilkgy hqygicavdf
781 sadgkrlasv giddshtivl wdwkkgekls vargskdkif vvkmnpyvpd klitagikhm
841 kfwrragggl igrkgyvgtl gkndtmmcav ygwteemafs gtstgdvciw rdvflvktvk
901 ahdgpvfsmh alekgfvtgg kdgvvalwdd sferclktya ikradlapgs kglllednps
961 iraislghgh ilvgtkngei levdksgpvt llvqghmege vwglathpyl picatvsddk
1021 tlriwdlsps hcmlavrklk kggrcccfsp dgkalavgln dgsflmanad tledlvsfhh
1081 rkdvisdiqf spgsgkylav ashdsfvdiy nvtsskrvgv ckgatsyith idwdsrgkll
1141 qvntgakeql ffeaprgkkq tipsveveki swatwtsvlg lccegiwpii gevtdvtasc
1201 ltsdkmvlat gddlgfvklf rypakgkfgk fkkyvahsth vtnvrwtydd smlvtlggad
1261 mslmvwtsev erhrekkncd seesdtdsee dggydsdvtr eneisytira lstnirpmfg
1321 vkphlqqkep svderqgvvr gsrppvsrap pqpeklqsnn vgkkkrpied lvlelafgyr
1381 grdcrnnvhy lndgddiiyh tasvgilhnv atgtqsfyqe hnddilcltv nqhpkfiniv
1441 atgqvgdsad msatapsvhi wdavnkqtls ilrcshskgv csvsfsatgk lllsvgldpe
1501 htvtiwrwqe gakiasrggh nqrifvaefr pdsdtqfvsv gikhvkfwtl agrallskkg
1561 llstledarm qtmlavafga nnltftgtis gdvcvwkdhi lcrvvarahn gpvfamyttl
1621 rdglivtggk erpskeggav klwdqelrrc rafrletgqv tdcvrsvcrg kgkilvgtrn
1681 seiievgekn aacnilvngh vdgpiwglat hpsrdfflsa aedgtvrlwd iadkkmlnkv
1741 nlghaartvc yspegdmvai gmkngefiil lvsslkiwgk krdrrcaihd irfspdsryl
1801 avgssensvd fydltlgptl nrisyckdip sfviqmdfsa dsrhlqvssg cykrhvyevp
1861 sgkhlvdhaa idritwatwt silgdevmgi wsrhaekadv tcacvshsgi slvtgddfgm
1921 vklydfpcpe kfakhkrflg hsphvtnirf tsgdrhvvsa ggddcsvfvw kcvhtph
//