LOCUS CORO6_HUMAN 6 aa linear PRI 27-NOV-2024
DEFINITION RecName: Full=Coronin-6; AltName: Full=Coronin-like protein E;
Short=Clipin-E.
ACCESSION Q6QEF8 REGION: 291..296
VERSION Q6QEF8.2
DBSOURCE UniProtKB: locus CORO6_HUMAN, accession Q6QEF8;
class: standard.
extra accessions:B3KU26,Q71MF3,Q8WYH7,Q96K02
created: Oct 31, 2006.
sequence updated: Oct 31, 2006.
annotation updated: Nov 27, 2024.
xrefs: AF193039.1, AAG22467.1, AF447884.1, AAQ04659.1, AF447885.1,
AAQ04660.1, AY545070.1, AAS48630.1, AK027777.1, BAB55360.1,
AK096431.1, BAG53288.1, AC104564.11, BC064514.1, AAH64514.1,
NP_116243.2, XP_005258104.1, XP_005258113.1, 7KYX_A
xrefs (non-sequence databases): CCDS:CCDS11252.2, PDBsum:7KYX,
AlphaFoldDB:Q6QEF8, SMR:Q6QEF8, BioGRID:124374, IntAct:Q6QEF8,
MINT:Q6QEF8, STRING:9606.ENSP00000344562, GlyGen:Q6QEF8,
iPTMnet:Q6QEF8, PhosphoSitePlus:Q6QEF8, BioMuta:CORO6,
DMDM:119369490, jPOST:Q6QEF8, MassIVE:Q6QEF8,
PaxDb:9606-ENSP00000344562, PeptideAtlas:Q6QEF8,
ProteomicsDB:67283, ProteomicsDB:67284, ProteomicsDB:67285,
ProteomicsDB:67286, ProteomicsDB:67287, Antibodypedia:54318,
DNASU:84940, Ensembl:ENST00000345068.9, Ensembl:ENSP00000344562.5,
Ensembl:ENSG00000167549.19, Ensembl:ENST00000388767.8,
Ensembl:ENSP00000373419.3, GeneID:84940, KEGG:hsa:84940,
MANE-Select:ENST00000388767.8, UCSC:uc002hel.2, AGR:HGNC:21356,
CTD:84940, DisGeNET:84940, GeneCards:CORO6, HGNC:21356,
HPA:ENSG00000167549, neXtProt:NX_Q6QEF8,
OpenTargets:ENSG00000167549, PharmGKB:PA134869901,
VEuPathDB:HostDB:ENSG00000167549, eggNOG:KOG0303,
GeneTree:ENSGT00940000159328, InParanoid:Q6QEF8, OMA:FRHSTGH,
OrthoDB:5474889at2759, PhylomeDB:Q6QEF8, TreeFam:TF314280,
PathwayCommons:Q6QEF8, SignaLink:Q6QEF8, BioGRID-ORCS:84940,
ChiTaRS:CORO6, GenomeRNAi:84940, Pharos:Q6QEF8, PRO:PR:Q6QEF8,
Proteomes:UP000005640, RNAct:Q6QEF8, Bgee:ENSG00000167549,
ExpressionAtlas:Q6QEF8, GO:0051015, GO:0007015, GO:0016477,
FunFam:2.130.10.10:FF:000003, Gene3D:2.130.10.10,
InterPro:IPR015505, InterPro:IPR015048, InterPro:IPR015943,
InterPro:IPR019775, InterPro:IPR036322, InterPro:IPR001680,
PANTHER:PTHR10856, PANTHER:PTHR10856:SF23, Pfam:PF08953,
Pfam:PF00400, Pfam:PF16300, SMART:SM01166, SMART:SM01167,
SMART:SM00320, SUPFAM:SSF50978, PROSITE:PS00678, PROSITE:PS50082,
PROSITE:PS50294
KEYWORDS 3D-structure; Alternative splicing; Coiled coil; Proteomics
identification; Reference proteome; Repeat; WD repeat.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues )
AUTHORS Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
Gu,J.
TITLE Large-scale cDNA transfection screening for genes related to cancer
development and progression
JOURNAL Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
PUBMED 15498874
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE 2 (residues )
AUTHORS Shen,C., Wang,C., Li,H., Zhou,G., Ke,R., Zhong,G., Lin,L. and
Yang,S.
TITLE Direct Submission
JOURNAL Submitted (??-FEB-2004) to the EMBL/GenBank/DDBJ databases
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
REFERENCE 3 (residues )
AUTHORS Ota,T., Suzuki,Y., Nishikawa,T., Otsuki,T., Sugiyama,T., Irie,R.,
Wakamatsu,A., Hayashi,K., Sato,H., Nagai,K., Kimura,K., Makita,H.,
Sekine,M., Obayashi,M., Nishi,T., Shibahara,T., Tanaka,T.,
Ishii,S., Yamamoto,J., Saito,K., Kawai,Y., Isono,Y., Nakamura,Y.,
Nagahari,K., Murakami,K., Yasuda,T., Iwayanagi,T., Wagatsuma,M.,
Shiratori,A., Sudo,H., Hosoiri,T., Kaku,Y., Kodaira,H., Kondo,H.,
Sugawara,M., Takahashi,M., Kanda,K., Yokoi,T., Furuya,T.,
Kikkawa,E., Omura,Y., Abe,K., Kamihara,K., Katsuta,N., Sato,K.,
Tanikawa,M., Yamazaki,M., Ninomiya,K., Ishibashi,T., Yamashita,H.,
Murakawa,K., Fujimori,K., Tanai,H., Kimata,M., Watanabe,M.,
Hiraoka,S., Chiba,Y., Ishida,S., Ono,Y., Takiguchi,S., Watanabe,S.,
Yosida,M., Hotuta,T., Kusano,J., Kanehori,K., Takahashi-Fujii,A.,
Hara,H., Tanase,T.O., Nomura,Y., Togiya,S., Komai,F., Hara,R.,
Takeuchi,K., Arita,M., Imose,N., Musashino,K., Yuuki,H., Oshima,A.,
Sasaki,N., Aotsuka,S., Yoshikawa,Y., Matsunawa,H., Ichihara,T.,
Shiohata,N., Sano,S., Moriya,S., Momiyama,H., Satoh,N., Takami,S.,
Terashima,Y., Suzuki,O., Nakagawa,S., Senoh,A., Mizoguchi,H.,
Goto,Y., Shimizu,F., Wakebe,H., Hishigaki,H., Watanabe,T.,
Sugiyama,A., Takemoto,M., Kawakami,B., Yamazaki,M., Watanabe,K.,
Kumagai,A., Itakura,S., Fukuzumi,Y., Fujimori,Y., Komiyama,M.,
Tashiro,H., Tanigami,A., Fujiwara,T., Ono,T., Yamada,K., Fujii,Y.,
Ozaki,K., Hirao,M., Ohmori,Y., Kawabata,A., Hikiji,T., Kobatake,N.,
Inagaki,H., Ikema,Y., Okamoto,S., Okitani,R., Kawakami,T.,
Noguchi,S., Itoh,T., Shigeta,K., Senba,T., Matsumura,K.,
Nakajima,Y., Mizuno,T., Morinaga,M., Sasaki,M., Togashi,T.,
Oyama,M., Hata,H., Watanabe,M., Komatsu,T., Mizushima-Sugano,J.,
Satoh,T., Shirai,Y., Takahashi,Y., Nakagawa,K., Okumura,K.,
Nagase,T., Nomura,N., Kikuchi,H., Masuho,Y., Yamashita,R.,
Nakai,K., Yada,T., Nakamura,Y., Ohara,O., Isogai,T. and Sugano,S.
TITLE Complete sequencing and characterization of 21,243 full-length
human cDNAs
JOURNAL Nat Genet 36 (1), 40-45 (2004)
PUBMED 14702039
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE
SEQUENCE [LARGE SCALE MRNA] OF 32-472 (ISOFORM 5).;
TISSUE=Placenta, and Tongue
REFERENCE 4 (residues )
AUTHORS Zody,M.C., Garber,M., Adams,D.J., Sharpe,T., Harrow,J.,
Lupski,J.R., Nicholson,C., Searle,S.M., Wilming,L., Young,S.K.,
Abouelleil,A., Allen,N.R., Bi,W., Bloom,T., Borowsky,M.L.,
Bugalter,B.E., Butler,J., Chang,J.L., Chen,C.K., Cook,A., Corum,B.,
Cuomo,C.A., de Jong,P.J., DeCaprio,D., Dewar,K., FitzGerald,M.,
Gilbert,J., Gibson,R., Gnerre,S., Goldstein,S., Grafham,D.V.,
Grocock,R., Hafez,N., Hagopian,D.S., Hart,E., Norman,C.H.,
Humphray,S., Jaffe,D.B., Jones,M., Kamal,M., Khodiyar,V.K.,
LaButti,K., Laird,G., Lehoczky,J., Liu,X., Lokyitsang,T.,
Loveland,J., Lui,A., Macdonald,P., Major,J.E., Matthews,L.,
Mauceli,E., McCarroll,S.A., Mihalev,A.H., Mudge,J., Nguyen,C.,
Nicol,R., O'Leary,S.B., Osoegawa,K., Schwartz,D.C., Shaw-Smith,C.,
Stankiewicz,P., Steward,C., Swarbreck,D., Venkataraman,V.,
Whittaker,C.A., Yang,X., Zimmer,A.R., Bradley,A., Hubbard,T.,
Birren,B.W., Rogers,J., Lander,E.S. and Nusbaum,C.
TITLE DNA sequence of human chromosome 17 and analysis of rearrangement
in the human lineage
JOURNAL Nature 440 (7087), 1045-1049 (2006)
PUBMED 16625196
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
REFERENCE 5 (residues )
AUTHORS Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
Makowski,K.A., Bosak,S. and Malek,J.
CONSRTM MGC Project Team
TITLE The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC)
JOURNAL Genome Res 14 (10B), 2121-2127 (2004)
PUBMED 15489334
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).;
TISSUE=Lymph
Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
Morin, Ryan]]
COMMENT On or before Dec 12, 2006 this sequence version replaced
gi:74738340, gi:74716455, gi:74716885, gi:74749291.
[INTERACTION] Q6QEF8; Q9UL45: BLOC1S6; NbExp=3;
IntAct=EBI-10254194, EBI-465781; Q6QEF8-4; P23560-2: BDNF; NbExp=3;
IntAct=EBI-10699285, EBI-12275524; Q6QEF8-4; P02511: CRYAB;
NbExp=3; IntAct=EBI-10699285, EBI-739060; Q6QEF8-4; P07900:
HSP90AA1; NbExp=3; IntAct=EBI-10699285, EBI-296047.
[ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named
isoforms=5; Name=1; IsoId=Q6QEF8-1; Sequence=Displayed; Name=2;
IsoId=Q6QEF8-2; Sequence=VSP_021484; Name=3; IsoId=Q6QEF8-3;
Sequence=VSP_021484, VSP_021486; Name=4; IsoId=Q6QEF8-4;
Sequence=VSP_021485, VSP_021486; Name=5; IsoId=Q6QEF8-5;
Sequence=VSP_039874.
[SEQUENCE CAUTION] Sequence=AAG22467.1; Type=Erroneous translation;
Note=Wrong choice of frame.; Evidence={ECO:0000305};
Sequence=BAG53288.1; Type=Erroneous initiation; Note=Truncated
N-terminus.; Evidence={ECO:0000305}.
FEATURES Location/Qualifiers
source 1..6
/organism="Homo sapiens"
/db_xref="taxon:9606"
gene <1..>6
/gene="CORO6"
/locus_tag="PP1009"
/gene_synonym="PP1782"
/gene_synonym="PP1881"
Protein <1..>6
/product="Coronin-6"
/note="Coronin-like protein E; Clipin-E"
/UniProtKB_evidence="Evidence at protein level"
Region <1..>6
/region_name="Mature chain"
/note="Coronin-6. /id=PRO_0000259596."
Region <1..>6
/region_name="WD40"
/note="WD40 domain, found in a number of eukaryotic
proteins that cover a wide variety of functions including
adaptor/regulatory modules in signal transduction,
pre-mRNA processing and cytoskeleton assembly; typically
contains a GH dipeptide 11-24 residues from...; cl29593"
/db_xref="CDD:475233"
Region <1..6
/region_name="Repetitive region"
/note="WD 6."
Region <1..>6
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 1..6
/region_name="Beta-strand region"
/note="/evidence=ECO:0007829|PDB:7KYX."
ORIGIN
1 iryfei
//