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RecName: Full=Coronin-6; AltName: Full=Coronin-like protein E; Short=Clipin-E

UniProtKB/Swiss-Prot: Q6QEF8.2

Identical Proteins FASTA Graphics 

LOCUS       CORO6_HUMAN                6 aa            linear   PRI 27-NOV-2024
DEFINITION  RecName: Full=Coronin-6; AltName: Full=Coronin-like protein E;
            Short=Clipin-E.
ACCESSION   Q6QEF8 REGION: 291..296
VERSION     Q6QEF8.2
DBSOURCE    UniProtKB: locus CORO6_HUMAN, accession Q6QEF8;
            class: standard.
            extra accessions:B3KU26,Q71MF3,Q8WYH7,Q96K02
            created: Oct 31, 2006.
            sequence updated: Oct 31, 2006.
            annotation updated: Nov 27, 2024.
            xrefs: AF193039.1, AAG22467.1, AF447884.1, AAQ04659.1, AF447885.1,
            AAQ04660.1, AY545070.1, AAS48630.1, AK027777.1, BAB55360.1,
            AK096431.1, BAG53288.1, AC104564.11, BC064514.1, AAH64514.1,
            NP_116243.2, XP_005258104.1, XP_005258113.1, 7KYX_A
            xrefs (non-sequence databases): CCDS:CCDS11252.2, PDBsum:7KYX,
            AlphaFoldDB:Q6QEF8, SMR:Q6QEF8, BioGRID:124374, IntAct:Q6QEF8,
            MINT:Q6QEF8, STRING:9606.ENSP00000344562, GlyGen:Q6QEF8,
            iPTMnet:Q6QEF8, PhosphoSitePlus:Q6QEF8, BioMuta:CORO6,
            DMDM:119369490, jPOST:Q6QEF8, MassIVE:Q6QEF8,
            PaxDb:9606-ENSP00000344562, PeptideAtlas:Q6QEF8,
            ProteomicsDB:67283, ProteomicsDB:67284, ProteomicsDB:67285,
            ProteomicsDB:67286, ProteomicsDB:67287, Antibodypedia:54318,
            DNASU:84940, Ensembl:ENST00000345068.9, Ensembl:ENSP00000344562.5,
            Ensembl:ENSG00000167549.19, Ensembl:ENST00000388767.8,
            Ensembl:ENSP00000373419.3, GeneID:84940, KEGG:hsa:84940,
            MANE-Select:ENST00000388767.8, UCSC:uc002hel.2, AGR:HGNC:21356,
            CTD:84940, DisGeNET:84940, GeneCards:CORO6, HGNC:21356,
            HPA:ENSG00000167549, neXtProt:NX_Q6QEF8,
            OpenTargets:ENSG00000167549, PharmGKB:PA134869901,
            VEuPathDB:HostDB:ENSG00000167549, eggNOG:KOG0303,
            GeneTree:ENSGT00940000159328, InParanoid:Q6QEF8, OMA:FRHSTGH,
            OrthoDB:5474889at2759, PhylomeDB:Q6QEF8, TreeFam:TF314280,
            PathwayCommons:Q6QEF8, SignaLink:Q6QEF8, BioGRID-ORCS:84940,
            ChiTaRS:CORO6, GenomeRNAi:84940, Pharos:Q6QEF8, PRO:PR:Q6QEF8,
            Proteomes:UP000005640, RNAct:Q6QEF8, Bgee:ENSG00000167549,
            ExpressionAtlas:Q6QEF8, GO:0051015, GO:0007015, GO:0016477,
            FunFam:2.130.10.10:FF:000003, Gene3D:2.130.10.10,
            InterPro:IPR015505, InterPro:IPR015048, InterPro:IPR015943,
            InterPro:IPR019775, InterPro:IPR036322, InterPro:IPR001680,
            PANTHER:PTHR10856, PANTHER:PTHR10856:SF23, Pfam:PF08953,
            Pfam:PF00400, Pfam:PF16300, SMART:SM01166, SMART:SM01167,
            SMART:SM00320, SUPFAM:SSF50978, PROSITE:PS00678, PROSITE:PS50082,
            PROSITE:PS50294
KEYWORDS    3D-structure; Alternative splicing; Coiled coil; Proteomics
            identification; Reference proteome; Repeat; WD repeat.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues )
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
            Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   2  (residues )
  AUTHORS   Shen,C., Wang,C., Li,H., Zhou,G., Ke,R., Zhong,G., Lin,L. and
            Yang,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (??-FEB-2004) to the EMBL/GenBank/DDBJ databases
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
REFERENCE   3  (residues )
  AUTHORS   Ota,T., Suzuki,Y., Nishikawa,T., Otsuki,T., Sugiyama,T., Irie,R.,
            Wakamatsu,A., Hayashi,K., Sato,H., Nagai,K., Kimura,K., Makita,H.,
            Sekine,M., Obayashi,M., Nishi,T., Shibahara,T., Tanaka,T.,
            Ishii,S., Yamamoto,J., Saito,K., Kawai,Y., Isono,Y., Nakamura,Y.,
            Nagahari,K., Murakami,K., Yasuda,T., Iwayanagi,T., Wagatsuma,M.,
            Shiratori,A., Sudo,H., Hosoiri,T., Kaku,Y., Kodaira,H., Kondo,H.,
            Sugawara,M., Takahashi,M., Kanda,K., Yokoi,T., Furuya,T.,
            Kikkawa,E., Omura,Y., Abe,K., Kamihara,K., Katsuta,N., Sato,K.,
            Tanikawa,M., Yamazaki,M., Ninomiya,K., Ishibashi,T., Yamashita,H.,
            Murakawa,K., Fujimori,K., Tanai,H., Kimata,M., Watanabe,M.,
            Hiraoka,S., Chiba,Y., Ishida,S., Ono,Y., Takiguchi,S., Watanabe,S.,
            Yosida,M., Hotuta,T., Kusano,J., Kanehori,K., Takahashi-Fujii,A.,
            Hara,H., Tanase,T.O., Nomura,Y., Togiya,S., Komai,F., Hara,R.,
            Takeuchi,K., Arita,M., Imose,N., Musashino,K., Yuuki,H., Oshima,A.,
            Sasaki,N., Aotsuka,S., Yoshikawa,Y., Matsunawa,H., Ichihara,T.,
            Shiohata,N., Sano,S., Moriya,S., Momiyama,H., Satoh,N., Takami,S.,
            Terashima,Y., Suzuki,O., Nakagawa,S., Senoh,A., Mizoguchi,H.,
            Goto,Y., Shimizu,F., Wakebe,H., Hishigaki,H., Watanabe,T.,
            Sugiyama,A., Takemoto,M., Kawakami,B., Yamazaki,M., Watanabe,K.,
            Kumagai,A., Itakura,S., Fukuzumi,Y., Fujimori,Y., Komiyama,M.,
            Tashiro,H., Tanigami,A., Fujiwara,T., Ono,T., Yamada,K., Fujii,Y.,
            Ozaki,K., Hirao,M., Ohmori,Y., Kawabata,A., Hikiji,T., Kobatake,N.,
            Inagaki,H., Ikema,Y., Okamoto,S., Okitani,R., Kawakami,T.,
            Noguchi,S., Itoh,T., Shigeta,K., Senba,T., Matsumura,K.,
            Nakajima,Y., Mizuno,T., Morinaga,M., Sasaki,M., Togashi,T.,
            Oyama,M., Hata,H., Watanabe,M., Komatsu,T., Mizushima-Sugano,J.,
            Satoh,T., Shirai,Y., Takahashi,Y., Nakagawa,K., Okumura,K.,
            Nagase,T., Nomura,N., Kikuchi,H., Masuho,Y., Yamashita,R.,
            Nakai,K., Yada,T., Nakamura,Y., Ohara,O., Isogai,T. and Sugano,S.
  TITLE     Complete sequencing and characterization of 21,243 full-length
            human cDNAs
  JOURNAL   Nat Genet 36 (1), 40-45 (2004)
   PUBMED   14702039
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE
            SEQUENCE [LARGE SCALE MRNA] OF 32-472 (ISOFORM 5).;
            TISSUE=Placenta, and Tongue
REFERENCE   4  (residues )
  AUTHORS   Zody,M.C., Garber,M., Adams,D.J., Sharpe,T., Harrow,J.,
            Lupski,J.R., Nicholson,C., Searle,S.M., Wilming,L., Young,S.K.,
            Abouelleil,A., Allen,N.R., Bi,W., Bloom,T., Borowsky,M.L.,
            Bugalter,B.E., Butler,J., Chang,J.L., Chen,C.K., Cook,A., Corum,B.,
            Cuomo,C.A., de Jong,P.J., DeCaprio,D., Dewar,K., FitzGerald,M.,
            Gilbert,J., Gibson,R., Gnerre,S., Goldstein,S., Grafham,D.V.,
            Grocock,R., Hafez,N., Hagopian,D.S., Hart,E., Norman,C.H.,
            Humphray,S., Jaffe,D.B., Jones,M., Kamal,M., Khodiyar,V.K.,
            LaButti,K., Laird,G., Lehoczky,J., Liu,X., Lokyitsang,T.,
            Loveland,J., Lui,A., Macdonald,P., Major,J.E., Matthews,L.,
            Mauceli,E., McCarroll,S.A., Mihalev,A.H., Mudge,J., Nguyen,C.,
            Nicol,R., O'Leary,S.B., Osoegawa,K., Schwartz,D.C., Shaw-Smith,C.,
            Stankiewicz,P., Steward,C., Swarbreck,D., Venkataraman,V.,
            Whittaker,C.A., Yang,X., Zimmer,A.R., Bradley,A., Hubbard,T.,
            Birren,B.W., Rogers,J., Lander,E.S. and Nusbaum,C.
  TITLE     DNA sequence of human chromosome 17 and analysis of rearrangement
            in the human lineage
  JOURNAL   Nature 440 (7087), 1045-1049 (2006)
   PUBMED   16625196
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
REFERENCE   5  (residues )
  AUTHORS   Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
            Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
            Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
            Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
            Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
            Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
            Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
            Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
            Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
            Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
            Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
            Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
            Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
            Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
            Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
            Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
            Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
            Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
            Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
            Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
            Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
            Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
            Makowski,K.A., Bosak,S. and Malek,J.
  CONSRTM   MGC Project Team
  TITLE     The status, quality, and expansion of the NIH full-length cDNA
            project: the Mammalian Gene Collection (MGC)
  JOURNAL   Genome Res 14 (10B), 2121-2127 (2004)
   PUBMED   15489334
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).;
            TISSUE=Lymph
            Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
            Morin, Ryan]]
COMMENT     On or before Dec 12, 2006 this sequence version replaced
            gi:74738340, gi:74716455, gi:74716885, gi:74749291.
            [INTERACTION] Q6QEF8; Q9UL45: BLOC1S6; NbExp=3;
            IntAct=EBI-10254194, EBI-465781; Q6QEF8-4; P23560-2: BDNF; NbExp=3;
            IntAct=EBI-10699285, EBI-12275524; Q6QEF8-4; P02511: CRYAB;
            NbExp=3; IntAct=EBI-10699285, EBI-739060; Q6QEF8-4; P07900:
            HSP90AA1; NbExp=3; IntAct=EBI-10699285, EBI-296047.
            [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named
            isoforms=5; Name=1; IsoId=Q6QEF8-1; Sequence=Displayed; Name=2;
            IsoId=Q6QEF8-2; Sequence=VSP_021484; Name=3; IsoId=Q6QEF8-3;
            Sequence=VSP_021484, VSP_021486; Name=4; IsoId=Q6QEF8-4;
            Sequence=VSP_021485, VSP_021486; Name=5; IsoId=Q6QEF8-5;
            Sequence=VSP_039874.
            [SEQUENCE CAUTION] Sequence=AAG22467.1; Type=Erroneous translation;
            Note=Wrong choice of frame.; Evidence={ECO:0000305};
            Sequence=BAG53288.1; Type=Erroneous initiation; Note=Truncated
            N-terminus.; Evidence={ECO:0000305}.
FEATURES             Location/Qualifiers
     source          1..6
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
     gene            <1..>6
                     /gene="CORO6"
                     /locus_tag="PP1009"
                     /gene_synonym="PP1782"
                     /gene_synonym="PP1881"
     Protein         <1..>6
                     /product="Coronin-6"
                     /note="Coronin-like protein E; Clipin-E"
                     /UniProtKB_evidence="Evidence at protein level"
     Region          <1..>6
                     /region_name="Mature chain"
                     /note="Coronin-6. /id=PRO_0000259596."
     Region          <1..>6
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          <1..6
                     /region_name="Repetitive region"
                     /note="WD 6."
     Region          <1..>6
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1..6
                     /region_name="Beta-strand region"
                     /note="/evidence=ECO:0007829|PDB:7KYX."
ORIGIN      
        1 iryfei
//
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