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RecName: Full=Transcription factor MYB63; AltName: Full=Myb-related protein 63; Short=AtMYB63

UniProtKB/Swiss-Prot: Q6R0A6.1

Identical Proteins FASTA Graphics 

LOCUS       MYB63_ARATH              294 aa            linear   PLN 27-NOV-2024
DEFINITION  RecName: Full=Transcription factor MYB63; AltName: Full=Myb-related
            protein 63; Short=AtMYB63.
ACCESSION   Q6R0A6
VERSION     Q6R0A6.1
DBSOURCE    UniProtKB: locus MYB63_ARATH, accession Q6R0A6;
            class: standard.
            extra accessions:O64534,Q9SBF8
            created: Jan 18, 2017.
            sequence updated: Jul 5, 2004.
            annotation updated: Nov 27, 2024.
            xrefs: AY519572.1, AAS10042.1, AC002986.1, AAC17044.1, CP002684.1,
            AEE36212.1, AK175344.1, BAD43107.1, BT033125.1, ACF22901.1,
            AF062898.1, AAC83620.1, T01038, T51670, NP_001321204.1, NP_178039.1
            xrefs (non-sequence databases): AlphaFoldDB:Q6R0A6, SMR:Q6R0A6,
            IntAct:Q6R0A6, STRING:3702.Q6R0A6, PaxDb:3702-AT1G79180.1,
            EnsemblPlants:AT1G79180.1, EnsemblPlants:AT1G79180.1,
            EnsemblPlants:AT1G79180, GeneID:844259, Gramene:AT1G79180.1,
            KEGG:ath:AT1G79180, Araport:AT1G79180, TAIR:AT1G79180,
            eggNOG:KOG0048, HOGENOM:CLU_028567_6_2_1, InParanoid:Q6R0A6,
            OrthoDB:887435at2759, PhylomeDB:Q6R0A6, PRO:PR:Q6R0A6,
            Proteomes:UP000006548, ExpressionAtlas:Q6R0A6, GO:0005634,
            GO:0003700, GO:0000976, GO:0009809, GO:0045893, GO:2000652,
            GO:0009411, CDD:cd00167, FunFam:1.10.10.60:FF:000623,
            FunFam:1.10.10.60:FF:000015, Gene3D:1.10.10.60, InterPro:IPR009057,
            InterPro:IPR017930, InterPro:IPR001005, PANTHER:PTHR10641,
            PANTHER:PTHR10641:SF1075, Pfam:PF00249, SMART:SM00717,
            SUPFAM:SSF46689, PROSITE:PS51294
KEYWORDS    Activator; DNA-binding; Lignin biosynthesis; Nucleus; Reference
            proteome; Repeat; Transcription; Transcription regulation.
SOURCE      Arabidopsis thaliana (thale cress)
  ORGANISM  Arabidopsis thaliana
            Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
            Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae;
            Pentapetalae; rosids; malvids; Brassicales; Brassicaceae;
            Camelineae; Arabidopsis.
REFERENCE   1  (residues 1 to 294)
  AUTHORS   Qu,L. and Gu,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (??-JAN-2004) to the EMBL/GenBank/DDBJ databases
  REMARK    NUCLEOTIDE SEQUENCE [MRNA].
REFERENCE   2  (residues 1 to 294)
  AUTHORS   Theologis,A., Ecker,J.R., Palm,C.J., Federspiel,N.A., Kaul,S.,
            White,O., Alonso,J., Altafi,H., Araujo,R., Bowman,C.L.,
            Brooks,S.Y., Buehler,E., Chan,A., Chao,Q., Chen,H., Cheuk,R.F.,
            Chin,C.W., Chung,M.K., Conn,L., Conway,A.B., Conway,A.R.,
            Creasy,T.H., Dewar,K., Dunn,P., Etgu,P., Feldblyum,T.V., Feng,J.,
            Fong,B., Fujii,C.Y., Gill,J.E., Goldsmith,A.D., Haas,B.,
            Hansen,N.F., Hughes,B., Huizar,L., Hunter,J.L., Jenkins,J.,
            Johnson-Hopson,C., Khan,S., Khaykin,E., Kim,C.J., Koo,H.L.,
            Kremenetskaia,I., Kurtz,D.B., Kwan,A., Lam,B., Langin-Hooper,S.,
            Lee,A., Lee,J.M., Lenz,C.A., Li,J.H., Li,Y., Lin,X., Liu,S.X.,
            Liu,Z.A., Luros,J.S., Maiti,R., Marziali,A., Militscher,J.,
            Miranda,M., Nguyen,M., Nierman,W.C., Osborne,B.I., Pai,G.,
            Peterson,J., Pham,P.K., Rizzo,M., Rooney,T., Rowley,D., Sakano,H.,
            Salzberg,S.L., Schwartz,J.R., Shinn,P., Southwick,A.M., Sun,H.,
            Tallon,L.J., Tambunga,G., Toriumi,M.J., Town,C.D., Utterback,T.,
            Van Aken,S., Vaysberg,M., Vysotskaia,V.S., Walker,M., Wu,D., Yu,G.,
            Fraser,C.M., Venter,J.C. and Davis,R.W.
  TITLE     Sequence and analysis of chromosome 1 of the plant Arabidopsis
            thaliana
  JOURNAL   Nature 408 (6814), 816-820 (2000)
   PUBMED   11130712
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
            STRAIN=cv. Columbia
REFERENCE   3  (residues 1 to 294)
  AUTHORS   Cheng,C.Y., Krishnakumar,V., Chan,A.P., Thibaud-Nissen,F.,
            Schobel,S. and Town,C.D.
  TITLE     Araport11: a complete reannotation of the Arabidopsis thaliana
            reference genome
  JOURNAL   Plant J 89 (4), 789-804 (2017)
   PUBMED   27862469
  REMARK    GENOME REANNOTATION.;
            STRAIN=cv. Columbia
REFERENCE   4  (residues 1 to 294)
  AUTHORS   Totoki,Y., Seki,M., Ishida,J., Nakajima,M., Enju,A., Kamiya,A.,
            Narusaka,M., Shin-i,T., Nakagawa,M., Sakamoto,N., Oishi,K.,
            Kohara,Y., Kobayashi,M., Toyoda,A., Sakaki,Y., Sakurai,T., Iida,K.,
            Akiyama,K., Satou,M., Toyoda,T., Konagaya,A., Carninci,P.,
            Kawai,J., Hayashizaki,Y. and Shinozaki,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (??-SEP-2004) to the EMBL/GenBank/DDBJ databases
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].;
            STRAIN=cv. Columbia
REFERENCE   5  (residues 1 to 294)
  AUTHORS   de los Reyes,C., Quan,R., Chen,H., Bautista,V., Kim,C.J. and
            Ecker,J.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (??-JUL-2008) to the EMBL/GenBank/DDBJ databases
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].;
            STRAIN=cv. Columbia
REFERENCE   6  (residues 1 to 294)
  AUTHORS   Kranz,H.D., Denekamp,M., Greco,R., Jin,H., Leyva,A., Meissner,R.C.,
            Petroni,K., Urzainqui,A., Bevan,M., Martin,C., Smeekens,S.,
            Tonelli,C., Paz-Ares,J. and Weisshaar,B.
  TITLE     Towards functional characterisation of the members of the R2R3-MYB
            gene family from Arabidopsis thaliana
  JOURNAL   Plant J 16 (2), 263-276 (1998)
   PUBMED   9839469
  REMARK    NUCLEOTIDE SEQUENCE [MRNA] OF 70-294, TISSUE SPECIFICITY, INDUCTION
            BY UV, GENE FAMILY, AND NOMENCLATURE.;
            STRAIN=cv. Columbia
REFERENCE   7  (residues 1 to 294)
  AUTHORS   Stracke,R., Werber,M. and Weisshaar,B.
  TITLE     The R2R3-MYB gene family in Arabidopsis thaliana
  JOURNAL   Curr Opin Plant Biol 4 (5), 447-456 (2001)
   PUBMED   11597504
  REMARK    GENE FAMILY, AND NOMENCLATURE.;
            STRAIN=cv. Columbia
REFERENCE   8  (residues 1 to 294)
  AUTHORS   Chen,Y., Yang,X., He,K., Liu,M., Li,J., Gao,Z., Lin,Z., Zhang,Y.,
            Wang,X., Qiu,X., Shen,Y., Zhang,L., Deng,X., Luo,J., Deng,X.-W.,
            Chen,Z., Gu,H. and Qu,L.-J.
  TITLE     The MYB transcription factor superfamily of Arabidopsis: expression
            analysis and phylogenetic comparison with the rice MYB family
  JOURNAL   Plant Mol. Biol. 60, 107-124 (2006)
   PUBMED   16463103
  REMARK    INDUCTION BY SALICYLIC ACID AND JASMONIC ACID.
REFERENCE   9  (residues 1 to 294)
  AUTHORS   Zhou,J., Lee,C., Zhong,R. and Ye,Z.H.
  TITLE     MYB58 and MYB63 are transcriptional activators of the lignin
            biosynthetic pathway during secondary cell wall formation in
            Arabidopsis
  JOURNAL   Plant Cell 21 (1), 248-266 (2009)
   PUBMED   19122102
  REMARK    FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, DEVELOPMENTAL
            STAGE, INDUCTION BY SND1 CLOSE HOMOLOGS, AND SUBCELLULAR LOCATION.;
            STRAIN=cv. Columbia
REFERENCE   10 (residues 1 to 294)
  AUTHORS   Zhong,R. and Ye,Z.H.
  TITLE     Transcriptional regulation of lignin biosynthesis
  JOURNAL   Plant Signal Behav 4 (11), 1028-1034 (2009)
   PUBMED   19838072
  REMARK    REVIEW.
REFERENCE   11 (residues 1 to 294)
  AUTHORS   Zhong,R. and Ye,Z.H.
  TITLE     MYB46 and MYB83 bind to the SMRE sites and directly activate a
            suite of transcription factors and secondary wall biosynthetic
            genes
  JOURNAL   Plant Cell Physiol 53 (2), 368-380 (2012)
   PUBMED   22197883
  REMARK    INDUCTION BY MYB46 AND MYB83.
COMMENT     On or before Jan 20, 2017 this sequence version replaced
            gi:75318466, gi:75274592.
            [FUNCTION] Transcriptional activator that binds DNA to the AC
            cis-elements 5'-ACCTACC-3', 5'-ACCAACC-3' and 5'-ACCTAAC-3' of
            promoters and specifically activates lignin biosynthetic genes
            during secondary wall formation mediated by SND1.
            {ECO:0000269|PubMed:19122102}.
            [INTERACTION] Q6R0A6; F4I171: MED15A; NbExp=3; IntAct=EBI-15198077,
            EBI-21254477.
            [SUBCELLULAR LOCATION] Nucleus
            {ECO:0000255|PROSITE-ProRule:PRU00625,
            ECO:0000269|PubMed:19122102}.
            [TISSUE SPECIFICITY] Expressed at low levels in stems, roots and
            siliques (PubMed:9839469). Specifically expressed in fibers and
            vessels undergoing secondary wall thickening, especially in
            inflorescence stems (PubMed:19122102).
            {ECO:0000269|PubMed:19122102, ECO:0000269|PubMed:9839469}.
            [DEVELOPMENTAL STAGE] In nonelongating internodes, highly expressed
            in interfascicular fibers and xylem cells but not in parenchymatous
            pith cells. In elongating internodes, predominantly expressed in
            interfascicular fibers. Accumulates in the developing secondary
            xylem of roots. {ECO:0000269|PubMed:19122102}.
            [INDUCTION] Slightly induced by UV light (PubMed:9839469).
            Triggered by salicylic acid and jasmonic acid (PubMed:16463103).
            Regulated by the SND1 close homologs NST1, NST2, VND6, and VND7 and
            their downstream targets MYB46 and MYB83 (PubMed:19122102,
            PubMed:22197883). {ECO:0000269|PubMed:16463103,
            ECO:0000269|PubMed:19122102, ECO:0000269|PubMed:22197883,
            ECO:0000269|PubMed:9839469}.
            [DISRUPTION PHENOTYPE] Reduction in secondary wall thickening and
            lignin content. {ECO:0000269|PubMed:19122102}.
            [SEQUENCE CAUTION] Sequence=AAC17044.1; Type=Erroneous gene model
            prediction; Evidence={ECO:0000305}.
FEATURES             Location/Qualifiers
     source          1..294
                     /organism="Arabidopsis thaliana"
                     /db_xref="taxon:3702"
     gene            1..294
                     /gene="MYB63"
                     /locus_tag="At1g79180"
                     /gene_synonym="YUP8H12R.21"
     Protein         1..294
                     /product="Transcription factor MYB63"
                     /note="Myb-related protein 63; AtMYB63"
                     /UniProtKB_evidence="Evidence at protein level"
     Region          1..294
                     /region_name="Mature chain"
                     /note="Transcription factor MYB63. /id=PRO_0000438720."
     Region          4..>239
                     /region_name="PLN03091"
                     /note="hypothetical protein; Provisional"
                     /db_xref="CDD:215570"
     Region          11..63
                     /region_name="Domain"
                     /note="HTH myb-type 1.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00625."
     Site            39..63
                     /site_type="DNA binding"
                     /note="H-T-H motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00625."
     Region          64..118
                     /region_name="Domain"
                     /note="HTH myb-type 2.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00625."
     Site            91..114
                     /site_type="DNA binding"
                     /note="H-T-H motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00625."
     Region          117..177
                     /region_name="Region of interest in the sequence"
                     /note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
     Region          117..136
                     /region_name="Compositionally biased region"
                     /note="Polar residues.
                     /evidence=ECO:0000256|SAM:MobiDB-lite."
     Region          137..157
                     /region_name="Compositionally biased region"
                     /note="Basic and acidic residues.
                     /evidence=ECO:0000256|SAM:MobiDB-lite."
     Region          158..175
                     /region_name="Compositionally biased region"
                     /note="Polar residues.
                     /evidence=ECO:0000256|SAM:MobiDB-lite."
     Region          174
                     /region_name="Conflict"
                     /note="Q -> QDD (in Ref. 6; AAC83620).
                     /evidence=ECO:0000305."
     Region          187..189
                     /region_name="Conflict"
                     /note="IEE -> TQ (in Ref. 6; AAC83620).
                     /evidence=ECO:0000305."
     Region          229..253
                     /region_name="Region of interest in the sequence"
                     /note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
     Region          266..288
                     /region_name="Region of interest in the sequence"
                     /note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
ORIGIN      
        1 mgkgrapccd ktkvkrgpws peediklisf iqkfghenwr slpkqsgllr cgkscrlrwi
       61 nylrpdlkrg nftseeeeti iklhhnygnk wskiasqlpg rtdneiknvw hthlkkrlaq
      121 ssgtadepas pcssdsvsrg kddksshved slnretnhrn elstsmssgg snqqddpkid
      181 elrfeyieea ysefndiiiq evdkpdllei pfdsdpdiws fldtsnsfqq stanenssgs
      241 ratteeesde devkkwfkhl eselgleedd nqqqykeees ssssllknye lmih
//
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