LOCUS MYB63_ARATH 294 aa linear PLN 27-NOV-2024
DEFINITION RecName: Full=Transcription factor MYB63; AltName: Full=Myb-related
protein 63; Short=AtMYB63.
ACCESSION Q6R0A6
VERSION Q6R0A6.1
DBSOURCE UniProtKB: locus MYB63_ARATH, accession Q6R0A6;
class: standard.
extra accessions:O64534,Q9SBF8
created: Jan 18, 2017.
sequence updated: Jul 5, 2004.
annotation updated: Nov 27, 2024.
xrefs: AY519572.1, AAS10042.1, AC002986.1, AAC17044.1, CP002684.1,
AEE36212.1, AK175344.1, BAD43107.1, BT033125.1, ACF22901.1,
AF062898.1, AAC83620.1, T01038, T51670, NP_001321204.1, NP_178039.1
xrefs (non-sequence databases): AlphaFoldDB:Q6R0A6, SMR:Q6R0A6,
IntAct:Q6R0A6, STRING:3702.Q6R0A6, PaxDb:3702-AT1G79180.1,
EnsemblPlants:AT1G79180.1, EnsemblPlants:AT1G79180.1,
EnsemblPlants:AT1G79180, GeneID:844259, Gramene:AT1G79180.1,
KEGG:ath:AT1G79180, Araport:AT1G79180, TAIR:AT1G79180,
eggNOG:KOG0048, HOGENOM:CLU_028567_6_2_1, InParanoid:Q6R0A6,
OrthoDB:887435at2759, PhylomeDB:Q6R0A6, PRO:PR:Q6R0A6,
Proteomes:UP000006548, ExpressionAtlas:Q6R0A6, GO:0005634,
GO:0003700, GO:0000976, GO:0009809, GO:0045893, GO:2000652,
GO:0009411, CDD:cd00167, FunFam:1.10.10.60:FF:000623,
FunFam:1.10.10.60:FF:000015, Gene3D:1.10.10.60, InterPro:IPR009057,
InterPro:IPR017930, InterPro:IPR001005, PANTHER:PTHR10641,
PANTHER:PTHR10641:SF1075, Pfam:PF00249, SMART:SM00717,
SUPFAM:SSF46689, PROSITE:PS51294
KEYWORDS Activator; DNA-binding; Lignin biosynthesis; Nucleus; Reference
proteome; Repeat; Transcription; Transcription regulation.
SOURCE Arabidopsis thaliana (thale cress)
ORGANISM Arabidopsis thaliana
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae;
Camelineae; Arabidopsis.
REFERENCE 1 (residues 1 to 294)
AUTHORS Qu,L. and Gu,H.
TITLE Direct Submission
JOURNAL Submitted (??-JAN-2004) to the EMBL/GenBank/DDBJ databases
REMARK NUCLEOTIDE SEQUENCE [MRNA].
REFERENCE 2 (residues 1 to 294)
AUTHORS Theologis,A., Ecker,J.R., Palm,C.J., Federspiel,N.A., Kaul,S.,
White,O., Alonso,J., Altafi,H., Araujo,R., Bowman,C.L.,
Brooks,S.Y., Buehler,E., Chan,A., Chao,Q., Chen,H., Cheuk,R.F.,
Chin,C.W., Chung,M.K., Conn,L., Conway,A.B., Conway,A.R.,
Creasy,T.H., Dewar,K., Dunn,P., Etgu,P., Feldblyum,T.V., Feng,J.,
Fong,B., Fujii,C.Y., Gill,J.E., Goldsmith,A.D., Haas,B.,
Hansen,N.F., Hughes,B., Huizar,L., Hunter,J.L., Jenkins,J.,
Johnson-Hopson,C., Khan,S., Khaykin,E., Kim,C.J., Koo,H.L.,
Kremenetskaia,I., Kurtz,D.B., Kwan,A., Lam,B., Langin-Hooper,S.,
Lee,A., Lee,J.M., Lenz,C.A., Li,J.H., Li,Y., Lin,X., Liu,S.X.,
Liu,Z.A., Luros,J.S., Maiti,R., Marziali,A., Militscher,J.,
Miranda,M., Nguyen,M., Nierman,W.C., Osborne,B.I., Pai,G.,
Peterson,J., Pham,P.K., Rizzo,M., Rooney,T., Rowley,D., Sakano,H.,
Salzberg,S.L., Schwartz,J.R., Shinn,P., Southwick,A.M., Sun,H.,
Tallon,L.J., Tambunga,G., Toriumi,M.J., Town,C.D., Utterback,T.,
Van Aken,S., Vaysberg,M., Vysotskaia,V.S., Walker,M., Wu,D., Yu,G.,
Fraser,C.M., Venter,J.C. and Davis,R.W.
TITLE Sequence and analysis of chromosome 1 of the plant Arabidopsis
thaliana
JOURNAL Nature 408 (6814), 816-820 (2000)
PUBMED 11130712
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
STRAIN=cv. Columbia
REFERENCE 3 (residues 1 to 294)
AUTHORS Cheng,C.Y., Krishnakumar,V., Chan,A.P., Thibaud-Nissen,F.,
Schobel,S. and Town,C.D.
TITLE Araport11: a complete reannotation of the Arabidopsis thaliana
reference genome
JOURNAL Plant J 89 (4), 789-804 (2017)
PUBMED 27862469
REMARK GENOME REANNOTATION.;
STRAIN=cv. Columbia
REFERENCE 4 (residues 1 to 294)
AUTHORS Totoki,Y., Seki,M., Ishida,J., Nakajima,M., Enju,A., Kamiya,A.,
Narusaka,M., Shin-i,T., Nakagawa,M., Sakamoto,N., Oishi,K.,
Kohara,Y., Kobayashi,M., Toyoda,A., Sakaki,Y., Sakurai,T., Iida,K.,
Akiyama,K., Satou,M., Toyoda,T., Konagaya,A., Carninci,P.,
Kawai,J., Hayashizaki,Y. and Shinozaki,K.
TITLE Direct Submission
JOURNAL Submitted (??-SEP-2004) to the EMBL/GenBank/DDBJ databases
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].;
STRAIN=cv. Columbia
REFERENCE 5 (residues 1 to 294)
AUTHORS de los Reyes,C., Quan,R., Chen,H., Bautista,V., Kim,C.J. and
Ecker,J.R.
TITLE Direct Submission
JOURNAL Submitted (??-JUL-2008) to the EMBL/GenBank/DDBJ databases
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].;
STRAIN=cv. Columbia
REFERENCE 6 (residues 1 to 294)
AUTHORS Kranz,H.D., Denekamp,M., Greco,R., Jin,H., Leyva,A., Meissner,R.C.,
Petroni,K., Urzainqui,A., Bevan,M., Martin,C., Smeekens,S.,
Tonelli,C., Paz-Ares,J. and Weisshaar,B.
TITLE Towards functional characterisation of the members of the R2R3-MYB
gene family from Arabidopsis thaliana
JOURNAL Plant J 16 (2), 263-276 (1998)
PUBMED 9839469
REMARK NUCLEOTIDE SEQUENCE [MRNA] OF 70-294, TISSUE SPECIFICITY, INDUCTION
BY UV, GENE FAMILY, AND NOMENCLATURE.;
STRAIN=cv. Columbia
REFERENCE 7 (residues 1 to 294)
AUTHORS Stracke,R., Werber,M. and Weisshaar,B.
TITLE The R2R3-MYB gene family in Arabidopsis thaliana
JOURNAL Curr Opin Plant Biol 4 (5), 447-456 (2001)
PUBMED 11597504
REMARK GENE FAMILY, AND NOMENCLATURE.;
STRAIN=cv. Columbia
REFERENCE 8 (residues 1 to 294)
AUTHORS Chen,Y., Yang,X., He,K., Liu,M., Li,J., Gao,Z., Lin,Z., Zhang,Y.,
Wang,X., Qiu,X., Shen,Y., Zhang,L., Deng,X., Luo,J., Deng,X.-W.,
Chen,Z., Gu,H. and Qu,L.-J.
TITLE The MYB transcription factor superfamily of Arabidopsis: expression
analysis and phylogenetic comparison with the rice MYB family
JOURNAL Plant Mol. Biol. 60, 107-124 (2006)
PUBMED 16463103
REMARK INDUCTION BY SALICYLIC ACID AND JASMONIC ACID.
REFERENCE 9 (residues 1 to 294)
AUTHORS Zhou,J., Lee,C., Zhong,R. and Ye,Z.H.
TITLE MYB58 and MYB63 are transcriptional activators of the lignin
biosynthetic pathway during secondary cell wall formation in
Arabidopsis
JOURNAL Plant Cell 21 (1), 248-266 (2009)
PUBMED 19122102
REMARK FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, DEVELOPMENTAL
STAGE, INDUCTION BY SND1 CLOSE HOMOLOGS, AND SUBCELLULAR LOCATION.;
STRAIN=cv. Columbia
REFERENCE 10 (residues 1 to 294)
AUTHORS Zhong,R. and Ye,Z.H.
TITLE Transcriptional regulation of lignin biosynthesis
JOURNAL Plant Signal Behav 4 (11), 1028-1034 (2009)
PUBMED 19838072
REMARK REVIEW.
REFERENCE 11 (residues 1 to 294)
AUTHORS Zhong,R. and Ye,Z.H.
TITLE MYB46 and MYB83 bind to the SMRE sites and directly activate a
suite of transcription factors and secondary wall biosynthetic
genes
JOURNAL Plant Cell Physiol 53 (2), 368-380 (2012)
PUBMED 22197883
REMARK INDUCTION BY MYB46 AND MYB83.
COMMENT On or before Jan 20, 2017 this sequence version replaced
gi:75318466, gi:75274592.
[FUNCTION] Transcriptional activator that binds DNA to the AC
cis-elements 5'-ACCTACC-3', 5'-ACCAACC-3' and 5'-ACCTAAC-3' of
promoters and specifically activates lignin biosynthetic genes
during secondary wall formation mediated by SND1.
{ECO:0000269|PubMed:19122102}.
[INTERACTION] Q6R0A6; F4I171: MED15A; NbExp=3; IntAct=EBI-15198077,
EBI-21254477.
[SUBCELLULAR LOCATION] Nucleus
{ECO:0000255|PROSITE-ProRule:PRU00625,
ECO:0000269|PubMed:19122102}.
[TISSUE SPECIFICITY] Expressed at low levels in stems, roots and
siliques (PubMed:9839469). Specifically expressed in fibers and
vessels undergoing secondary wall thickening, especially in
inflorescence stems (PubMed:19122102).
{ECO:0000269|PubMed:19122102, ECO:0000269|PubMed:9839469}.
[DEVELOPMENTAL STAGE] In nonelongating internodes, highly expressed
in interfascicular fibers and xylem cells but not in parenchymatous
pith cells. In elongating internodes, predominantly expressed in
interfascicular fibers. Accumulates in the developing secondary
xylem of roots. {ECO:0000269|PubMed:19122102}.
[INDUCTION] Slightly induced by UV light (PubMed:9839469).
Triggered by salicylic acid and jasmonic acid (PubMed:16463103).
Regulated by the SND1 close homologs NST1, NST2, VND6, and VND7 and
their downstream targets MYB46 and MYB83 (PubMed:19122102,
PubMed:22197883). {ECO:0000269|PubMed:16463103,
ECO:0000269|PubMed:19122102, ECO:0000269|PubMed:22197883,
ECO:0000269|PubMed:9839469}.
[DISRUPTION PHENOTYPE] Reduction in secondary wall thickening and
lignin content. {ECO:0000269|PubMed:19122102}.
[SEQUENCE CAUTION] Sequence=AAC17044.1; Type=Erroneous gene model
prediction; Evidence={ECO:0000305}.
FEATURES Location/Qualifiers
source 1..294
/organism="Arabidopsis thaliana"
/db_xref="taxon:3702"
gene 1..294
/gene="MYB63"
/locus_tag="At1g79180"
/gene_synonym="YUP8H12R.21"
Protein 1..294
/product="Transcription factor MYB63"
/note="Myb-related protein 63; AtMYB63"
/UniProtKB_evidence="Evidence at protein level"
Region 1..294
/region_name="Mature chain"
/note="Transcription factor MYB63. /id=PRO_0000438720."
Region 4..>239
/region_name="PLN03091"
/note="hypothetical protein; Provisional"
/db_xref="CDD:215570"
Region 11..63
/region_name="Domain"
/note="HTH myb-type 1.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00625."
Site 39..63
/site_type="DNA binding"
/note="H-T-H motif.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00625."
Region 64..118
/region_name="Domain"
/note="HTH myb-type 2.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00625."
Site 91..114
/site_type="DNA binding"
/note="H-T-H motif.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00625."
Region 117..177
/region_name="Region of interest in the sequence"
/note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
Region 117..136
/region_name="Compositionally biased region"
/note="Polar residues.
/evidence=ECO:0000256|SAM:MobiDB-lite."
Region 137..157
/region_name="Compositionally biased region"
/note="Basic and acidic residues.
/evidence=ECO:0000256|SAM:MobiDB-lite."
Region 158..175
/region_name="Compositionally biased region"
/note="Polar residues.
/evidence=ECO:0000256|SAM:MobiDB-lite."
Region 174
/region_name="Conflict"
/note="Q -> QDD (in Ref. 6; AAC83620).
/evidence=ECO:0000305."
Region 187..189
/region_name="Conflict"
/note="IEE -> TQ (in Ref. 6; AAC83620).
/evidence=ECO:0000305."
Region 229..253
/region_name="Region of interest in the sequence"
/note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
Region 266..288
/region_name="Region of interest in the sequence"
/note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
ORIGIN
1 mgkgrapccd ktkvkrgpws peediklisf iqkfghenwr slpkqsgllr cgkscrlrwi
61 nylrpdlkrg nftseeeeti iklhhnygnk wskiasqlpg rtdneiknvw hthlkkrlaq
121 ssgtadepas pcssdsvsrg kddksshved slnretnhrn elstsmssgg snqqddpkid
181 elrfeyieea ysefndiiiq evdkpdllei pfdsdpdiws fldtsnsfqq stanenssgs
241 ratteeesde devkkwfkhl eselgleedd nqqqykeees ssssllknye lmih
//