RecName: Full=tRNA (guanine(26)-N(2))-dimethyltransferase; AltName: Fu - Protein

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Human TRMT1 catalyzes m(2)G or m(2)(2)G formation on tRNAs in a substrate-dependent manner. [Sci China Life Sci. 2023]
Human TRMT1 catalyzes m(2)G or m(2)(2)G formation on tRNAs in a substrate-dependent manner.
Xiong QP, Li J, Li H, Huang ZX, Dong H, Wang ED, Liu RJ. Sci China Life Sci. 2023 Oct; 66(10):2295-2309. Epub 2023 May 11.
SARS-CoV-2 main protease Nsp5 cleaves and inactivates human tRNA methyltransferase TRMT1. [J Mol Cell Biol. 2023]
SARS-CoV-2 main protease Nsp5 cleaves and inactivates human tRNA methyltransferase TRMT1.
Lu JL, Zhou XL. J Mol Cell Biol. 2023 Aug 3; 15(4).
An intellectual disability-associated missense variant in TRMT1 impairs tRNA modification and reconstitution of enzymatic activity. [Hum Mutat. 2020]
An intellectual disability-associated missense variant in TRMT1 impairs tRNA modification and reconstitution of enzymatic activity.
Zhang K, Lentini JM, Prevost CT, Hashem MO, Alkuraya FS, Fu D. Hum Mutat. 2020 Mar; 41(3):600-607. Epub 2020 Jan 16.

RefSeq genomic sequence
See the genomic reference sequence for the TRMT1 gene (NG_054900.1).
RefSeq protein isoforms
See 6 reference sequence protein isoforms for the TRMT1 gene.

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Q9NXH9 [Domain Mapping of Disease Mut...]
Q9NXH9
Domain Mapping of Disease Mutations
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF) [MODBASE, Database of Comparat...]
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF)
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
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Reactome [Reactome]
Reactome
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reagents
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