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MULTISPECIES: type II toxin-antitoxin system Phd/YefM family antitoxin [Enterobacterales]

NCBI Reference Sequence: WP_004118488.1

Identical Proteins FASTA Graphics 

LOCUS       WP_004118488              83 aa            linear   BCT 15-JUL-2024
DEFINITION  MULTISPECIES: type II toxin-antitoxin system Phd/YefM family
            antitoxin [Enterobacterales].
ACCESSION   WP_004118488
VERSION     WP_004118488.1
KEYWORDS    RefSeq.
SOURCE      Enterobacterales
  ORGANISM  Enterobacterales
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria.
REFERENCE   1  (residues 1 to 83)
  AUTHORS   Garcia-Pino,A., De Gieter,S., Talavera,A., De Greve,H.,
            Efremov,R.G. and Loris,R.
  TITLE     An intrinsically disordered entropic switch determines allostery in
            Phd-Doc regulation
  JOURNAL   Nat Chem Biol 12 (7), 490-496 (2016)
   PUBMED   27159580
REFERENCE   2  (residues 1 to 83)
  AUTHORS   Garcia-Pino,A., Christensen-Dalsgaard,M., Wyns,L., Yarmolinsky,M.,
            Magnuson,R.D., Gerdes,K. and Loris,R.
  TITLE     Doc of prophage P1 is inhibited by its antitoxin partner Phd
            through fold complementation
  JOURNAL   J Biol Chem 283 (45), 30821-30827 (2008)
   PUBMED   18757857
REFERENCE   3  (residues 1 to 83)
  AUTHORS   Magnuson,R. and Yarmolinsky,M.B.
  TITLE     Corepression of the P1 addiction operon by Phd and Doc
  JOURNAL   J Bacteriol 180 (23), 6342-6351 (1998)
   PUBMED   9829946
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: Conserved Domain (CDD)
            Evidence Accession :: Domain architecture ID 10005482
            Evidence Source    :: NCBI SPARCLE
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..83
                     /organism="Enterobacterales"
                     /db_xref="taxon:91347"
     Protein         1..83
                     /product="type II toxin-antitoxin system Phd/YefM family
                     antitoxin"
                     /GO_component="GO:0110001 - toxin-antitoxin complex
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0097351 - toxin sequestering activity [Evidence IEA]"
                     /GO_process="GO:0045927 - positive regulation of growth
                     [Evidence IEA]; GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /calculated_mol_wt=9094
     Region          10..76
                     /region_name="StbD"
                     /note="Antitoxin component YafN of the YafNO
                     toxin-antitoxin module, PHD/YefM family [Defense
                     mechanisms]; COG2161"
                     /db_xref="CDD:441764"
ORIGIN      
        1 mtniilcdvt asiselkndp vatasagggy pvaiidrnrp vfycvpaaly eqmldaldek
       61 dlvqliterq nqplrevdln qyl
//
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Protein clusters for WP_004118488.1

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