phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 pro - Protein

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PREX1 improves homeostatic proliferation to maintain a naive CD4+ T cell compartment in older age. [JCI Insight. 2024]
PREX1 improves homeostatic proliferation to maintain a naive CD4+ T cell compartment in older age.
Zhang H, Okuyama H, Jain A, Jadhav RR, Wu B, Sturmlechner I, Morales J, Ohtsuki S, Weyand CM, Goronzy JJ. JCI Insight. 2024 Feb 8; 9(5). Epub 2024 Feb 8.
Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism. [Nat Struct Mol Biol. 2022]
Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism.
Chang YG, Lupton CJ, Bayly-Jones C, Keen AC, D'Andrea L, Lucato CM, Steele JR, Venugopal H, Schittenhelm RB, Whisstock JC, et al. Nat Struct Mol Biol. 2022 Aug; 29(8):767-773. Epub 2022 Jul 21.
Gβγ recruits and activates P-Rex1 via two independent binding interfaces. [Biochem Biophys Res Commun. 2021]
Gβγ recruits and activates P-Rex1 via two independent binding interfaces.
Cervantes-Villagrana RD, Beltrán-Navarro YM, García-Jiménez I, Adame-García SR, Olguín-Olguín A, Reyes-Cruz G, Vázquez-Prado J. Biochem Biophys Res Commun. 2021 Feb 5; 539:20-27. Epub 2021 Jan 4.

RefSeq mRNA
See reference mRNA sequence for the PREX1 gene (XM_011528934.2).
RefSeq protein isoforms
See 9 reference sequence protein isoforms for the PREX1 gene.

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Protein