mitogen-activated protein kinase kinase kinase kinase 3 isoform X2 [Mu - Protein

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MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKβ and inducing IKKβ-mediated FoxO1 nuclear export and Foxp3 downregulation. [Theranostics. 2022]
MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKβ and inducing IKKβ-mediated FoxO1 nuclear export and Foxp3 downregulation.
Chi JN, Yang JY, Hsueh CH, Tsai CY, Chuang HC, Tan TH. Theranostics. 2022; 12(13):5744-5760. Epub 2022 Jul 18.
The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells. [Nat Immunol. 2011]
The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells.
Chuang HC, Lan JL, Chen DY, Yang CY, Chen YM, Li JP, Huang CY, Liu PE, Wang X, Tan TH. Nat Immunol. 2011 Oct 9; 12(11):1113-8. Epub 2011 Oct 9.
GLK-IKKβ signaling induces dimerization and translocation of the AhR-RORγt complex in IL-17A induction and autoimmune disease. [Sci Adv. 2018]
GLK-IKKβ signaling induces dimerization and translocation of the AhR-RORγt complex in IL-17A induction and autoimmune disease.
Chuang HC, Tsai CY, Hsueh CH, Tan TH. Sci Adv. 2018 Sep; 4(9):eaat5401. Epub 2018 Sep 12.

RefSeq protein isoforms
See 13 reference sequence protein isoforms for the Map4k3 gene.

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Protein