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nucleotide-binding oligomerization domain-containing protein 1 isoform X8 [Homo sapiens]

NCBI Reference Sequence: XP_054213051.1

Identical Proteins FASTA Graphics 

LOCUS       XP_054213051             821 aa            linear   PRI 26-AUG-2024
DEFINITION  nucleotide-binding oligomerization domain-containing protein 1
            isoform X8 [Homo sapiens].
ACCESSION   XP_054213051
VERSION     XP_054213051.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054357076.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060931) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..821
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..821
                     /product="nucleotide-binding oligomerization
                     domain-containing protein 1 isoform X8"
                     /calculated_mol_wt=93142
     Region          21..105
                     /region_name="CARD_NOD1_CARD4"
                     /note="Caspase activation and recruitment domain similar
                     to that found in NOD1; cd08324"
                     /db_xref="CDD:260035"
     Site            order(26,29..30,33..36,38..40,42,46,87,90..91,93..101,
                     103..104)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:260035"
     Region          190..>542
                     /region_name="NACHT"
                     /note="Predicted NTPase, NACHT family domain [Signal
                     transduction mechanisms]; COG5635"
                     /db_xref="CDD:444362"
     Region          197..367
                     /region_name="NACHT"
                     /note="NACHT domain; pfam05729"
                     /db_xref="CDD:428606"
     Region          517..665
                     /region_name="NLRC4_HD2"
                     /note="NLRC4 helical domain HD2; pfam17776"
                     /db_xref="CDD:465499"
     Region          <730..817
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          730..757
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          758..785
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..821
                     /gene="NOD1"
                     /gene_synonym="CARD4; CLR7.1; hNod1; NLRC1"
                     /coded_by="XM_054357076.1:621..3086"
                     /db_xref="GeneID:10392"
                     /db_xref="HGNC:HGNC:16390"
                     /db_xref="MIM:605980"
ORIGIN      
        1 meeqghseme iipseshphi qllksnrell vthirntqcl vdnllkndyf saedaeivca
       61 cptqpdkvrk ildlvqskge evsefflyll qqladayvdl rpwlleigfs pslltqskvv
      121 vntdpvsryt qqlrhhlgrd skfvlcyaqk eellleeiym dtimelvgfs neslgslnsl
      181 aclldhttgi lneqgetifi lgdagvgksm llqrlqslwa tgrldagvkf ffhfrcrmfs
      241 cfkesdrlcl qdllfkhycy perdpeevfa fllrfphval ftfdgldelh sdldlsrvpd
      301 sscpwepahp lvllanllsg kllkgaskll tartgievpr qflrkkvllr gfspshlray
      361 arrmfperal qdrllsqlea npnlcslcsv plfcwiifrc fqhfraafeg spqlpdctmt
      421 ltdvfllvte vhlnrmqpss lvqrntrspv etlhagrdtl cslgqvahrg mekslfvftq
      481 eevqasglqe rdmqlgflra lpelgpggdq qsyeffhltl qafftafflv lddrvgtqel
      541 lrffqewmpp agaattscyp pflpfqclqg sgparedlfk nkdhfqftnl flcgllskak
      601 qkllrhlvpa aalrrkrkal wahlfsslrg ylkslprvqv esfnqvqamp tfiwmlrciy
      661 etqsqkvgql aargicanyl kltycnacsa dcsalsfvlh hfpkrlaldl dnnnlndygv
      721 relqpcfsrl tvlrlsvnqi tdggvkvlse eltkykivty lglynnqitd vgaryvtkil
      781 deckglthlk lgknkitseg gkylalavkn sksisevgwg n
//
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