LOCUS NP_001347366 1029 aa linear ROD 12-JUN-2024
DEFINITION DNA cross-link repair 1A protein isoform 1 [Mus musculus].
ACCESSION NP_001347366 XP_006527279
VERSION NP_001347366.2
DBSOURCE REFSEQ: accession NM_001360437.2
KEYWORDS RefSeq; RefSeq Select.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 1029)
AUTHORS Yan,Y., Akhter,S., Zhang,X. and Legerski,R.
TITLE The multifunctional SNM1 gene family: not just nucleases
JOURNAL Future Oncol 6 (6), 1015-1029 (2010)
PUBMED 20528238
REMARK Review article
REFERENCE 2 (residues 1 to 1029)
AUTHORS Akhter,S. and Legerski,R.J.
TITLE SNM1A acts downstream of ATM to promote the G1 cell cycle
checkpoint
JOURNAL Biochem Biophys Res Commun 377 (1), 236-241 (2008)
PUBMED 18848520
REFERENCE 3 (residues 1 to 1029)
AUTHORS Hemphill,A.W., Bruun,D., Thrun,L., Akkari,Y., Torimaru,Y.,
Hejna,K., Jakobs,P.M., Hejna,J., Jones,S., Olson,S.B. and
Moses,R.E.
TITLE Mammalian SNM1 is required for genome stability
JOURNAL Mol Genet Metab 94 (1), 38-45 (2008)
PUBMED 18180189
REFERENCE 4 (residues 1 to 1029)
AUTHORS Ahkter,S., Richie,C.T., Zhang,N., Behringer,R.R., Zhu,C. and
Legerski,R.J.
TITLE Snm1-deficient mice exhibit accelerated tumorigenesis and
susceptibility to infection
JOURNAL Mol Cell Biol 25 (22), 10071-10078 (2005)
PUBMED 16260620
REMARK GeneRIF: Snm1 is a tumor suppressor in mice that in addition has a
role in immunity
REFERENCE 5 (residues 1 to 1029)
AUTHORS Bonatto,D., Revers,L.F., Brendel,M. and Henriques,J.A.
TITLE The eukaryotic Pso2/Snm1/Artemis proteins and their function as
genomic and cellular caretakers
JOURNAL Braz J Med Biol Res 38 (3), 321-334 (2005)
PUBMED 15761611
REMARK Review article
REFERENCE 6 (residues 1 to 1029)
AUTHORS Akhter,S., Richie,C.T., Deng,J.M., Brey,E., Zhang,X., Patrick,C.
Jr., Behringer,R.R. and Legerski,R.J.
TITLE Deficiency in SNM1 abolishes an early mitotic checkpoint induced by
spindle stress
JOURNAL Mol Cell Biol 24 (23), 10448-10455 (2004)
PUBMED 15542852
REMARK GeneRIF: Snm1 and 53BP1 are components of a mitotic stress
checkpoint that negatively targets the APC prior to chromosome
condensation
REFERENCE 7 (residues 1 to 1029)
AUTHORS Dronkert,M.L., de Wit,J., Boeve,M., Vasconcelos,M.L., van Steeg,H.,
Tan,T.L., Hoeijmakers,J.H. and Kanaar,R.
TITLE Disruption of mouse SNM1 causes increased sensitivity to the DNA
interstrand cross-linking agent mitomycin C
JOURNAL Mol Cell Biol 20 (13), 4553-4561 (2000)
PUBMED 10848582
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC166746.7.
On Apr 8, 2021 this sequence version replaced NP_001347366.1.
##Evidence-Data-START##
Transcript exon combination :: SRR1660813.86804.1,
SRR1660811.122403.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN01164143 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
is not conserved
RefSeq Select criteria :: based on conservation,
expression
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..1029
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="19"
/map="19 51.89 cM"
Protein 1..1029
/product="DNA cross-link repair 1A protein isoform 1"
/EC_number="3.5.2.6"
/note="DNA cross-link repair 1A protein; SNM1 homolog A;
DNA cross-link repair 1A, PSO2 homolog; beta-lactamase
MBLAC2"
/calculated_mol_wt=113855
Region 13..111
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q9JIC3.2)"
Region 402..603
/region_name="Nuclear focus formation.
/evidence=ECO:0000250"
/note="propagated from UniProtKB/Swiss-Prot (Q9JIC3.2)"
Region 475..543
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q9JIC3.2)"
Region 561..591
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q9JIC3.2)"
Site 575
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:21183079; propagated from
UniProtKB/Swiss-Prot (Q9JIC3.2)"
Site 579
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:21183079; propagated from
UniProtKB/Swiss-Prot (Q9JIC3.2)"
Region 603..652
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q9JIC3.2)"
Region 678..833
/region_name="metallo-hydrolase-like_MBL-fold"
/note="mainly hydrolytic enzymes and related proteins
which carry out various biological functions; MBL-fold
metallohydrolase domain; cl23716"
/db_xref="CDD:451500"
Site order(721,723,725..726,782..783,804,827)
/site_type="active"
/db_xref="CDD:293792"
Region 903..1009
/region_name="DRMBL"
/note="DNA repair metallo-beta-lactamase; pfam07522"
/db_xref="CDD:429512"
CDS 1..1029
/gene="Dclre1a"
/gene_synonym="2810043H12Rik; mKIAA0086; Pso2; Smn1a;
Snm1"
/coded_by="NM_001360437.2:760..3849"
/note="isoform 1 is encoded by transcript variant 2"
/db_xref="CCDS:CCDS29917.2"
/db_xref="GeneID:55947"
/db_xref="MGI:MGI:1930042"
ORIGIN
1 mledtfweee iweykskrkp kpvhpnncse nisesvekst dgkhqskgne krtsenpgkt
61 kdhkvclaet dsqisagssq ssscrdesqq sqnkettpkk qhrtrrgkqv tpkvrpvydg
121 ycpscqmpfs sllgqtpqwh vfecldsppi sdtecpegll ctstipshyk kythillaqs
181 rdskeplgsp sdalaglfaa aapgspcnle errsmtlkte nlrkvsdhsl lmmqyletsq
241 psaeinrknv sspcsqtspv pqcaefvkrd qlvgggspla evalnsqsks gsmglplpen
301 dtdsceisys plhsdeetyd idqelddsqq elfftqsskd ssleedgsai fenlhgpspk
361 eaegirptak slvaqarcsa psegstlsds flllfytsnr lsqedlphtd aafhllspal
421 avggaasnyq tskakldepe kflslasshq qqkietsavg nqtslplltr arskplekeg
481 gkclplhptq sqtrgsprkg lgapgancac rnaqkrssmp ldkplgtsps spkcspsqps
541 kkvmkqmdig vffglppkrq etslresase gpnvspvvsp nqkrprlckr kaqsslsdle
601 fdaknlnesq hsvglsgekr qhrrkrhkts nspregpcqr rsghlmnnpe lgpvilskgk
661 afvrrtrgrt qrgnmnises sgagevrrtc pfykripgtg ftvdafqyge iegctayflt
721 hfhsdhyagl skdftrpvyc seitgnllkk klrvqeqyir qlpmdtecvv dsvkvvllda
781 nhcpgatmil fqlpngavil htgdfradps mersrlagrk vhtlfldtty cspeytfpsq
841 qeviqfaint afeavtlnpr alvvcgtyci gkekvflaia dvlgskvgms qekyktlqcl
901 nipevsslit tdmcdslvhl lpmmqinfkg lqshlkkcgg kydqilafrp tgwthsnnit
961 stadiipqtr gnisiygipy sehssylemk rfvqwlkpqk iiptvnvgsf rsrntmekyf
1021 kewrleagy
//