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DNA cross-link repair 1A protein isoform 1 [Mus musculus]

NCBI Reference Sequence: NP_001347366.2

Identical Proteins FASTA Graphics 

LOCUS       NP_001347366            1029 aa            linear   ROD 12-JUN-2024
DEFINITION  DNA cross-link repair 1A protein isoform 1 [Mus musculus].
ACCESSION   NP_001347366 XP_006527279
VERSION     NP_001347366.2
DBSOURCE    REFSEQ: accession NM_001360437.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1029)
  AUTHORS   Yan,Y., Akhter,S., Zhang,X. and Legerski,R.
  TITLE     The multifunctional SNM1 gene family: not just nucleases
  JOURNAL   Future Oncol 6 (6), 1015-1029 (2010)
   PUBMED   20528238
  REMARK    Review article
REFERENCE   2  (residues 1 to 1029)
  AUTHORS   Akhter,S. and Legerski,R.J.
  TITLE     SNM1A acts downstream of ATM to promote the G1 cell cycle
            checkpoint
  JOURNAL   Biochem Biophys Res Commun 377 (1), 236-241 (2008)
   PUBMED   18848520
REFERENCE   3  (residues 1 to 1029)
  AUTHORS   Hemphill,A.W., Bruun,D., Thrun,L., Akkari,Y., Torimaru,Y.,
            Hejna,K., Jakobs,P.M., Hejna,J., Jones,S., Olson,S.B. and
            Moses,R.E.
  TITLE     Mammalian SNM1 is required for genome stability
  JOURNAL   Mol Genet Metab 94 (1), 38-45 (2008)
   PUBMED   18180189
REFERENCE   4  (residues 1 to 1029)
  AUTHORS   Ahkter,S., Richie,C.T., Zhang,N., Behringer,R.R., Zhu,C. and
            Legerski,R.J.
  TITLE     Snm1-deficient mice exhibit accelerated tumorigenesis and
            susceptibility to infection
  JOURNAL   Mol Cell Biol 25 (22), 10071-10078 (2005)
   PUBMED   16260620
  REMARK    GeneRIF: Snm1 is a tumor suppressor in mice that in addition has a
            role in immunity
REFERENCE   5  (residues 1 to 1029)
  AUTHORS   Bonatto,D., Revers,L.F., Brendel,M. and Henriques,J.A.
  TITLE     The eukaryotic Pso2/Snm1/Artemis proteins and their function as
            genomic and cellular caretakers
  JOURNAL   Braz J Med Biol Res 38 (3), 321-334 (2005)
   PUBMED   15761611
  REMARK    Review article
REFERENCE   6  (residues 1 to 1029)
  AUTHORS   Akhter,S., Richie,C.T., Deng,J.M., Brey,E., Zhang,X., Patrick,C.
            Jr., Behringer,R.R. and Legerski,R.J.
  TITLE     Deficiency in SNM1 abolishes an early mitotic checkpoint induced by
            spindle stress
  JOURNAL   Mol Cell Biol 24 (23), 10448-10455 (2004)
   PUBMED   15542852
  REMARK    GeneRIF: Snm1 and 53BP1 are components of a mitotic stress
            checkpoint that negatively targets the APC prior to chromosome
            condensation
REFERENCE   7  (residues 1 to 1029)
  AUTHORS   Dronkert,M.L., de Wit,J., Boeve,M., Vasconcelos,M.L., van Steeg,H.,
            Tan,T.L., Hoeijmakers,J.H. and Kanaar,R.
  TITLE     Disruption of mouse SNM1 causes increased sensitivity to the DNA
            interstrand cross-linking agent mitomycin C
  JOURNAL   Mol Cell Biol 20 (13), 4553-4561 (2000)
   PUBMED   10848582
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166746.7.
            
            On Apr 8, 2021 this sequence version replaced NP_001347366.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.86804.1,
                                           SRR1660811.122403.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1029
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 51.89 cM"
     Protein         1..1029
                     /product="DNA cross-link repair 1A protein isoform 1"
                     /EC_number="3.5.2.6"
                     /note="DNA cross-link repair 1A protein; SNM1 homolog A;
                     DNA cross-link repair 1A, PSO2 homolog; beta-lactamase
                     MBLAC2"
                     /calculated_mol_wt=113855
     Region          13..111
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIC3.2)"
     Region          402..603
                     /region_name="Nuclear focus formation.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIC3.2)"
     Region          475..543
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIC3.2)"
     Region          561..591
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIC3.2)"
     Site            575
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9JIC3.2)"
     Site            579
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9JIC3.2)"
     Region          603..652
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIC3.2)"
     Region          678..833
                     /region_name="metallo-hydrolase-like_MBL-fold"
                     /note="mainly hydrolytic enzymes and related proteins
                     which carry out various biological functions; MBL-fold
                     metallohydrolase domain; cl23716"
                     /db_xref="CDD:451500"
     Site            order(721,723,725..726,782..783,804,827)
                     /site_type="active"
                     /db_xref="CDD:293792"
     Region          903..1009
                     /region_name="DRMBL"
                     /note="DNA repair metallo-beta-lactamase; pfam07522"
                     /db_xref="CDD:429512"
     CDS             1..1029
                     /gene="Dclre1a"
                     /gene_synonym="2810043H12Rik; mKIAA0086; Pso2; Smn1a;
                     Snm1"
                     /coded_by="NM_001360437.2:760..3849"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS29917.2"
                     /db_xref="GeneID:55947"
                     /db_xref="MGI:MGI:1930042"
ORIGIN      
        1 mledtfweee iweykskrkp kpvhpnncse nisesvekst dgkhqskgne krtsenpgkt
       61 kdhkvclaet dsqisagssq ssscrdesqq sqnkettpkk qhrtrrgkqv tpkvrpvydg
      121 ycpscqmpfs sllgqtpqwh vfecldsppi sdtecpegll ctstipshyk kythillaqs
      181 rdskeplgsp sdalaglfaa aapgspcnle errsmtlkte nlrkvsdhsl lmmqyletsq
      241 psaeinrknv sspcsqtspv pqcaefvkrd qlvgggspla evalnsqsks gsmglplpen
      301 dtdsceisys plhsdeetyd idqelddsqq elfftqsskd ssleedgsai fenlhgpspk
      361 eaegirptak slvaqarcsa psegstlsds flllfytsnr lsqedlphtd aafhllspal
      421 avggaasnyq tskakldepe kflslasshq qqkietsavg nqtslplltr arskplekeg
      481 gkclplhptq sqtrgsprkg lgapgancac rnaqkrssmp ldkplgtsps spkcspsqps
      541 kkvmkqmdig vffglppkrq etslresase gpnvspvvsp nqkrprlckr kaqsslsdle
      601 fdaknlnesq hsvglsgekr qhrrkrhkts nspregpcqr rsghlmnnpe lgpvilskgk
      661 afvrrtrgrt qrgnmnises sgagevrrtc pfykripgtg ftvdafqyge iegctayflt
      721 hfhsdhyagl skdftrpvyc seitgnllkk klrvqeqyir qlpmdtecvv dsvkvvllda
      781 nhcpgatmil fqlpngavil htgdfradps mersrlagrk vhtlfldtty cspeytfpsq
      841 qeviqfaint afeavtlnpr alvvcgtyci gkekvflaia dvlgskvgms qekyktlqcl
      901 nipevsslit tdmcdslvhl lpmmqinfkg lqshlkkcgg kydqilafrp tgwthsnnit
      961 stadiipqtr gnisiygipy sehssylemk rfvqwlkpqk iiptvnvgsf rsrntmekyf
     1021 kewrleagy
//
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