LOCUS VNN2_HUMAN 520 aa linear PRI 27-NOV-2024
DEFINITION RecName: Full=Pantetheine hydrolase VNN2; AltName:
Full=Glycosylphosphatidyl inositol-anchored protein GPI-80;
AltName: Full=Protein FOAP-4; AltName: Full=Vascular
non-inflammatory molecule 2; Short=Vanin-2; Flags: Precursor.
ACCESSION O95498
VERSION O95498.3
DBSOURCE UniProtKB: locus VNN2_HUMAN, accession O95498;
class: standard.
extra
accessions:A0AUZ3,A6NDY1,A8K4E3,A8K7W0,B2DFZ0,B2DFZ1,B2DFZ2,B2DFZ3,
F6XL73,Q2XUN1,Q9UJF3,Q9UMW2
created: Apr 27, 2001.
sequence updated: Mar 20, 2007.
annotation updated: Nov 27, 2024.
xrefs: AJ132100.1, CAA10569.1, D89974.1, BAA82525.1, AB435062.1,
BAG30934.1, AB435063.1, BAG30935.1, AB435064.1, BAG30936.1,
AB435065.1, BAG30937.1, AB026705.1, BAB61019.1, AK290908.1,
BAF83597.1, AK292125.1, BAF84814.1, DQ249347.1, ABB72673.1,
AL032821.2, CH471051.2, EAW48016.1, BC126145.1, AAI26146.1,
BC126147.1, AAI26148.1, NP_001229279.1, NP_004656.2, NP_511043.1,
XP_006715656.1, XP_016866896.1
xrefs (non-sequence databases): CCDS:CCDS5161.1, CCDS:CCDS5162.1,
CCDS:CCDS56451.1, AlphaFoldDB:O95498, SMR:O95498, BioGRID:114394,
IntAct:O95498, STRING:9606.ENSP00000322276, GlyConnect:2089,
GlyCosmos:O95498, GlyGen:O95498, iPTMnet:O95498,
PhosphoSitePlus:O95498, SwissPalm:O95498, BioMuta:VNN2,
jPOST:O95498, MassIVE:O95498, PaxDb:9606-ENSP00000322276,
PeptideAtlas:O95498, ProteomicsDB:28159, ProteomicsDB:50925,
ProteomicsDB:50926, ProteomicsDB:50927, ProteomicsDB:50928,
ProteomicsDB:50929, Antibodypedia:32943, DNASU:8875,
Ensembl:ENST00000326499.11, Ensembl:ENSP00000322276.6,
Ensembl:ENSG00000112303.14, Ensembl:ENST00000525270.5,
Ensembl:ENSP00000436822.1, Ensembl:ENST00000525289.5,
Ensembl:ENSP00000436935.1, Ensembl:ENST00000525674.5,
Ensembl:ENSP00000436863.1, Ensembl:ENST00000532053.5,
Ensembl:ENSP00000434077.1, GeneID:8875, KEGG:hsa:8875,
MANE-Select:ENST00000326499.11, UCSC:uc003qdt.4, AGR:HGNC:12706,
CTD:8875, DisGeNET:8875, GeneCards:VNN2, HGNC:12706,
HPA:ENSG00000112303, MIM 603571, neXtProt:NX_O95498,
OpenTargets:ENSG00000112303, PharmGKB:PA37322,
VEuPathDB:HostDB:ENSG00000112303, eggNOG:KOG0806,
GeneTree:ENSGT00390000013823, HOGENOM:CLU_033209_2_0_1,
InParanoid:O95498, OMA:PCNSHDS, OrthoDB:4006627at2759,
PhylomeDB:O95498, TreeFam:TF323645, BRENDA:3.5.1.92,
PathwayCommons:O95498, Reactome:R-HSA-163125,
Reactome:R-HSA-199220, SignaLink:O95498, BioGRID-ORCS:8875,
GeneWiki:VNN2, GenomeRNAi:8875, Pharos:O95498, PRO:PR:O95498,
Proteomes:UP000005640, RNAct:O95498, Bgee:ENSG00000112303,
ExpressionAtlas:O95498, GO:0005576, GO:0005886, GO:0098552,
GO:0017159, GO:0015939, CDD:cd07567, FunFam:3.60.110.10:FF:000001,
Gene3D:3.60.110.10, InterPro:IPR012101, InterPro:IPR040154,
InterPro:IPR003010, InterPro:IPR036526, InterPro:IPR043957,
PANTHER:PTHR10609, PANTHER:PTHR10609:SF15, Pfam:PF00795,
Pfam:PF19018, PIRSF:PIRSF011861, SUPFAM:SSF56317, PROSITE:PS50263
KEYWORDS Alternative splicing; Cell membrane; Glycoprotein; GPI-anchor;
Hydrolase; Lipoprotein; Membrane; Proteomics identification;
Reference proteome; Signal.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 520)
AUTHORS Galland,F., Malergue,F., Bazin,H., Mattei,M.G., Aurrand-Lions,M.,
Theillet,C. and Naquet,P.
TITLE Two human genes related to murine vanin-1 are located on the long
arm of human chromosome 6
JOURNAL Genomics 53 (2), 203-213 (1998)
PUBMED 9790769
REMARK NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT MET-404.;
TISSUE=Kidney
REFERENCE 2 (residues 1 to 520)
AUTHORS Suzuki,K., Watanabe,T., Sakurai,S., Ohtake,K., Kinoshita,T.,
Araki,A., Fujita,T., Takei,H., Takeda,Y., Sato,Y., Yamashita,T.,
Araki,Y. and Sendo,F.
TITLE A novel glycosylphosphatidyl inositol-anchored protein on human
leukocytes: a possible role for regulation of neutrophil adherence
and migration
JOURNAL J Immunol 162 (7), 4277-4284 (1999)
PUBMED 10201959
REMARK NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT MET-404.;
TISSUE=Peripheral blood
REFERENCE 3 (residues 1 to 520)
AUTHORS Nitto,T., Inoue,T. and Node,K.
TITLE Alternative spliced variants in the pantetheinase family of genes
expressed in human neutrophils
JOURNAL Gene 426 (1-2), 57-64 (2008)
PUBMED 18805469
REMARK NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4 AND 5), AND VARIANT
MET-404.;
TISSUE=Neutrophil
REFERENCE 4 (residues 1 to 520)
AUTHORS Takayama,K., Fujii,Y., Tsuritani,K., Yajima,Y., Amemiya,T.,
Ukai,Y., Naito,K. and Kawaguchi,A.
TITLE Direct Submission
JOURNAL Submitted (??-APR-1999) to the EMBL/GenBank/DDBJ databases
REMARK NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT MET-404.;
TISSUE=Blood
REFERENCE 5 (residues 1 to 520)
AUTHORS Ota,T., Suzuki,Y., Nishikawa,T., Otsuki,T., Sugiyama,T., Irie,R.,
Wakamatsu,A., Hayashi,K., Sato,H., Nagai,K., Kimura,K., Makita,H.,
Sekine,M., Obayashi,M., Nishi,T., Shibahara,T., Tanaka,T.,
Ishii,S., Yamamoto,J., Saito,K., Kawai,Y., Isono,Y., Nakamura,Y.,
Nagahari,K., Murakami,K., Yasuda,T., Iwayanagi,T., Wagatsuma,M.,
Shiratori,A., Sudo,H., Hosoiri,T., Kaku,Y., Kodaira,H., Kondo,H.,
Sugawara,M., Takahashi,M., Kanda,K., Yokoi,T., Furuya,T.,
Kikkawa,E., Omura,Y., Abe,K., Kamihara,K., Katsuta,N., Sato,K.,
Tanikawa,M., Yamazaki,M., Ninomiya,K., Ishibashi,T., Yamashita,H.,
Murakawa,K., Fujimori,K., Tanai,H., Kimata,M., Watanabe,M.,
Hiraoka,S., Chiba,Y., Ishida,S., Ono,Y., Takiguchi,S., Watanabe,S.,
Yosida,M., Hotuta,T., Kusano,J., Kanehori,K., Takahashi-Fujii,A.,
Hara,H., Tanase,T.O., Nomura,Y., Togiya,S., Komai,F., Hara,R.,
Takeuchi,K., Arita,M., Imose,N., Musashino,K., Yuuki,H., Oshima,A.,
Sasaki,N., Aotsuka,S., Yoshikawa,Y., Matsunawa,H., Ichihara,T.,
Shiohata,N., Sano,S., Moriya,S., Momiyama,H., Satoh,N., Takami,S.,
Terashima,Y., Suzuki,O., Nakagawa,S., Senoh,A., Mizoguchi,H.,
Goto,Y., Shimizu,F., Wakebe,H., Hishigaki,H., Watanabe,T.,
Sugiyama,A., Takemoto,M., Kawakami,B., Yamazaki,M., Watanabe,K.,
Kumagai,A., Itakura,S., Fukuzumi,Y., Fujimori,Y., Komiyama,M.,
Tashiro,H., Tanigami,A., Fujiwara,T., Ono,T., Yamada,K., Fujii,Y.,
Ozaki,K., Hirao,M., Ohmori,Y., Kawabata,A., Hikiji,T., Kobatake,N.,
Inagaki,H., Ikema,Y., Okamoto,S., Okitani,R., Kawakami,T.,
Noguchi,S., Itoh,T., Shigeta,K., Senba,T., Matsumura,K.,
Nakajima,Y., Mizuno,T., Morinaga,M., Sasaki,M., Togashi,T.,
Oyama,M., Hata,H., Watanabe,M., Komatsu,T., Mizushima-Sugano,J.,
Satoh,T., Shirai,Y., Takahashi,Y., Nakagawa,K., Okumura,K.,
Nagase,T., Nomura,N., Kikuchi,H., Masuho,Y., Yamashita,R.,
Nakai,K., Yada,T., Nakamura,Y., Ohara,O., Isogai,T. and Sugano,S.
TITLE Complete sequencing and characterization of 21,243 full-length
human cDNAs
JOURNAL Nat Genet 36 (1), 40-45 (2004)
PUBMED 14702039
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 6), AND
VARIANT MET-404.;
TISSUE=Synovium
REFERENCE 6 (residues 1 to 520)
CONSRTM NIEHS SNPs program
TITLE Direct Submission
JOURNAL Submitted (??-OCT-2005) to the EMBL/GenBank/DDBJ databases
REMARK NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ASN-17; GLU-112;
ILE-241; SER-349 AND MET-404.
REFERENCE 7 (residues 1 to 520)
AUTHORS Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
Dunham,I., Rogers,J. and Beck,S.
TITLE The DNA sequence and analysis of human chromosome 6
JOURNAL Nature 425 (6960), 805-811 (2003)
PUBMED 14574404
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
REFERENCE 8 (residues 1 to 520)
AUTHORS Mural,R.J., Istrail,S., Sutton,G., Florea,L., Halpern,A.L.,
Mobarry,C.M., Lippert,R., Walenz,B., Shatkay,H., Dew,I.,
Miller,J.R., Flanigan,M.J., Edwards,N.J., Bolanos,R., Fasulo,D.,
Halldorsson,B.V., Hannenhalli,S., Turner,R., Yooseph,S., Lu,F.,
Nusskern,D.R., Shue,B.C., Zheng,X.H., Zhong,F., Delcher,A.L.,
Huson,D.H., Kravitz,S.A., Mouchard,L., Reinert,K., Remington,K.A.,
Clark,A.G., Waterman,M.S., Eichler,E.E., Adams,M.D.,
Hunkapiller,M.W., Myers,E.W. and Venter,J.C.
TITLE Direct Submission
JOURNAL Submitted (??-SEP-2005) to the EMBL/GenBank/DDBJ databases
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
REFERENCE 9 (residues 1 to 520)
AUTHORS Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
Makowski,K.A., Bosak,S. and Malek,J.
CONSRTM MGC Project Team
TITLE The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC)
JOURNAL Genome Res 14 (10B), 2121-2127 (2004)
PUBMED 15489334
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
MET-404.
Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
Morin, Ryan]]
REFERENCE 10 (residues 1 to 520)
AUTHORS Martin,F., Malergue,F., Pitari,G., Philippe,J.M., Philips,S.,
Chabret,C., Granjeaud,S., Mattei,M.G., Mungall,A.J., Naquet,P. and
Galland,F.
TITLE Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and
encode isoforms of pantetheinase ectoenzymes
JOURNAL Immunogenetics 53 (4), 296-306 (2001)
PUBMED 11491533
REMARK FUNCTION, AND CATALYTIC ACTIVITY.
REFERENCE 11 (residues 1 to 520)
AUTHORS Liu,T., Qian,W.J., Gritsenko,M.A., Camp,D.G. II, Monroe,M.E.,
Moore,R.J. and Smith,R.D.
TITLE Human plasma N-glycoproteome analysis by immunoaffinity
subtraction, hydrazide chemistry, and mass spectrometry
JOURNAL J Proteome Res 4 (6), 2070-2080 (2005)
PUBMED 16335952
REMARK GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-411.;
TISSUE=Plasma
REFERENCE 12 (residues 1 to 520)
AUTHORS Jansen,P.A., Kamsteeg,M., Rodijk-Olthuis,D., van
Vlijmen-Willems,I.M., de Jongh,G.J., Bergers,M., Tjabringa,G.S.,
Zeeuwen,P.L. and Schalkwijk,J.
TITLE Expression of the vanin gene family in normal and inflamed human
skin: induction by proinflammatory cytokines
JOURNAL J Invest Dermatol 129 (9), 2167-2174 (2009)
PUBMED 19322213
REMARK TISSUE SPECIFICITY.
COMMENT On Mar 23, 2007 this sequence version replaced gi:13431962.
[FUNCTION] Amidohydrolase that hydrolyzes specifically one of the
carboamide linkages in D-pantetheine thus recycling pantothenic
acid (vitamin B5) and releasing cysteamine (PubMed:11491533).
Involved in the thymus homing of bone marrow cells. May regulate
beta-2 integrin-mediated cell adhesion, migration and motility of
neutrophil. {ECO:0000269|PubMed:11491533}.
[CATALYTIC ACTIVITY] Reaction=(R)-pantetheine + H2O = cysteamine +
(R)-pantothenate; Xref=Rhea:RHEA:13445, ChEBI:CHEBI:15377,
ChEBI:CHEBI:16753, ChEBI:CHEBI:29032, ChEBI:CHEBI:58029;
EC=3.5.1.92; Evidence={ECO:0000269|PubMed:11491533};
PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13446;
Evidence={ECO:0000305|PubMed:11491533}.
[INTERACTION] O95498; Q92993: KAT5; NbExp=3; IntAct=EBI-21494555,
EBI-399080; O95498; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-21494555,
EBI-11742507; O95498; P17252: PRKCA; NbExp=3; IntAct=EBI-21494555,
EBI-1383528; O95498; Q15047-2: SETDB1; NbExp=3;
IntAct=EBI-21494555, EBI-9090795; O95498; P61981: YWHAG; NbExp=3;
IntAct=EBI-21494555, EBI-359832.
[SUBCELLULAR LOCATION] Cell membrane {ECO:0000305}; Lipid-anchor,
GPI-anchor {ECO:0000305}.
[ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named
isoforms=6; Name=1; IsoId=O95498-1; Sequence=Displayed; Name=2;
Synonyms=GPI-80 variant protein 3; IsoId=O95498-2;
Sequence=VSP_038557; Name=3; Synonyms=GPI-80 variant protein 2;
IsoId=O95498-3; Sequence=VSP_038558, VSP_038559; Name=4;
Synonyms=GPI-80 variant protein 1; IsoId=O95498-4;
Sequence=VSP_038556, VSP_038560; Name=5; Synonyms=GPI-80 variant
protein 4; IsoId=O95498-5; Sequence=VSP_038554, VSP_038555; Name=6;
IsoId=O95498-6; Sequence=VSP_044912.
[TISSUE SPECIFICITY] Widely expressed with higher expression in
spleen and blood. {ECO:0000269|PubMed:19322213}.
[MISCELLANEOUS] [Isoform 3]: May be produced at very low levels due
to a premature stop codon in the mRNA, leading to nonsense-mediated
mRNA decay. {ECO:0000305}.
[MISCELLANEOUS] [Isoform 4]: May be produced at very low levels due
to a premature stop codon in the mRNA, leading to nonsense-mediated
mRNA decay. {ECO:0000305}.
[MISCELLANEOUS] [Isoform 5]: May be produced at very low levels due
to a premature stop codon in the mRNA, leading to nonsense-mediated
mRNA decay. {ECO:0000305}.
[SIMILARITY] Belongs to the carbon-nitrogen hydrolase superfamily.
BTD/VNN family. {ECO:0000305}.
FEATURES Location/Qualifiers
source 1..520
/organism="Homo sapiens"
/db_xref="taxon:9606"
gene 1..520
/gene="VNN2"
Protein 1..520
/product="Pantetheine hydrolase VNN2"
/EC_number="3.5.1.92"
/note="Glycosylphosphatidyl inositol-anchored protein
GPI-80; Protein FOAP-4; Vascular non-inflammatory molecule
2; Vanin-2"
/UniProtKB_evidence="Evidence at protein level"
Region 1..53
/region_name="Splicing variant"
/note="Missing (in isoform 6).
/evidence=ECO:0000303|PubMed:14702039. /id=VSP_044912."
Region 1..22
/region_name="Signal"
/note="/evidence=ECO:0000255."
Region 17
/region_name="Variant"
/note="T -> N (in dbSNP:rs33950336).
/evidence=ECO:0000269|Ref.6. /id=VAR_025177."
Region 23..493
/region_name="Mature chain"
/note="Pantetheine hydrolase VNN2. /id=PRO_0000019718."
Region 26..329
/region_name="biotinidase_like"
/note="biotinidase and vanins (class 4 nitrilases);
cd07567"
/db_xref="CDD:143591"
Region 30
/region_name="Variant"
/note="V -> A (in dbSNP:rs2294760). /id=VAR_031261."
Region 31..306
/region_name="Domain"
/note="CN hydrolase.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00054."
Site 39
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255."
Site order(80,179,183,185,211..212,214..215,237)
/site_type="active"
/note="putative active site [active]"
/db_xref="CDD:143591"
Site order(80,179,211)
/site_type="active"
/note="catalytic triad [active]"
/db_xref="CDD:143591"
Site 80
/site_type="active"
/note="Proton acceptor.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00054."
Region 112
/region_name="Variant"
/note="D -> E (in dbSNP:rs35993077).
/evidence=ECO:0000269|Ref.6. /id=VAR_025178."
Region 116..119
/region_name="Splicing variant"
/note="FGHT -> SAQC (in isoform 5).
/evidence=ECO:0000303|PubMed:18805469. /id=VSP_038554."
Region 120..520
/region_name="Splicing variant"
/note="Missing (in isoform 5).
/evidence=ECO:0000303|PubMed:18805469. /id=VSP_038555."
Site 179
/site_type="active"
/note="Proton donor.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00054."
Region 180..400
/region_name="Splicing variant"
/note="Missing (in isoform 2).
/evidence=ECO:0000303|PubMed:18805469. /id=VSP_038557."
Site order(180..184,191..193,212,214..218,221..222,243..244,
246..248,250..251,275..276,325..329)
/site_type="other"
/note="putative dimer interface [polypeptide binding]"
/db_xref="CDD:143591"
Region 180..195
/region_name="Splicing variant"
/note="YHLYSEPQFNVPEKPE -> EVVFMHQMVPKCIIMT (in isoform
4). /evidence=ECO:0000303|PubMed:18805469.
/id=VSP_038556."
Region 180..192
/region_name="Splicing variant"
/note="YHLYSEPQFNVPE -> ETLQSVKRSFAVI (in isoform 3).
/evidence=ECO:0000303|PubMed:18805469. /id=VSP_038558."
Region 193..520
/region_name="Splicing variant"
/note="Missing (in isoform 3).
/evidence=ECO:0000303|PubMed:18805469. /id=VSP_038559."
Region 196..520
/region_name="Splicing variant"
/note="Missing (in isoform 4).
/evidence=ECO:0000303|PubMed:18805469. /id=VSP_038560."
Site 211
/site_type="active"
/note="Nucleophile.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00054."
Region 218
/region_name="Conflict"
/note="D -> Y (in Ref. 1; CAA10569).
/evidence=ECO:0000305."
Region 241
/region_name="Variant"
/note="V -> I (in dbSNP:rs33920182).
/evidence=ECO:0000269|Ref.6. /id=VAR_025179."
Site 273
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255."
Region 344..487
/region_name="Vanin_C"
/note="Vanin C-terminal domain; pfam19018"
/db_xref="CDD:465946"
Site 347
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255."
Region 349
/region_name="Variant"
/note="T -> S (in dbSNP:rs36092168).
/evidence=ECO:0000269|Ref.6. /id=VAR_025180."
Site 357
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255."
Region 404
/region_name="Variant"
/note="L -> M (in dbSNP:rs4895944).
/evidence=ECO:0000269|PubMed:10201959,
ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334,
ECO:0000269|PubMed:18805469, ECO:0000269|PubMed:9790769,
ECO:0000269|Ref.4, ECO:0000269|Ref.6. /id=VAR_023530."
Site 411
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000269|PubMed:16335952."
Site 468
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255."
Site 493
/site_type="lipid-binding"
/note="GPI-anchor amidated cysteine.
/evidence=ECO:0000255."
Region 494..520
/region_name="Propeptide"
/note="Removed in mature form. /evidence=ECO:0000255.
/id=PRO_0000019719."
ORIGIN
1 mvtssfpisv avfalitlqv gtqdsfiaav yehavilpnk tetpvsqeda lnlmnenidi
61 letaikqaae qgariivtpe dalygwkftr etvfpyledi pdpqvnwipc qdphrfghtp
121 vqarlsclak dnsiyvlanl gdkkpcnsrd stcppngyfq yntnvvynte gklvaryhky
181 hlysepqfnv pekpelvtfn tafgrfgift cfdiffydpg vtlvkdfhvd tilfptawmn
241 vlplltaief hsawamgmgv nllvanthhv slnmtgsgiy apngpkvyhy dmktelgkll
301 lsevdshpls slayptavnw nayattikpf pvqkntfrgf isrdgfnfte lfenagnltv
361 cqkelcchls yrmlqkeene vyvlgaftgl hgrrrreywq vctllkcktt nlttcgrpve
421 tastrfemfs lsgtfgteyv fpevllteih lspgkfevlk dgrlvnkngs sgpiltvslf
481 grwytkdsly sscgtsnsai tyllifillm iialqnivml
//