Protein Family Models for Gene (Select 24256676) - Protein Family Models

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Items: 5

Select item 4033521.

new record, indexing in progress

Family Accession:

Select item 3646782.

new record, indexing in progress

Family Accession:

Select item 1967883.

RNA chaperone Hfq

RNA chaperone Hfq is an RNA-binding protein that functions as a regulator of small non-coding RNAs

Date:: 2023-02-28

Family Accession:: 10791943
Method:: Sparcle

Select item 495794.

RNA chaperone Hfq

This model represents the RNA-binding pleiotropic regulator Hfq, a small, Sm-like protein of bacteria. It helps pair regulatory noncoding RNAs with complementary mRNA target regions. It enhances the elongation of poly(A) tails on mRNA. It appears also to protect RNase E recognition sites (A/U-rich sequences with adjacent stem-loop structures) from cleavage. Being pleiotropic, it differs in some of its activities in different species. Hfq binds the non-coding regulatory RNA DsrA (see Rfam RF00014) in the few species known to have it: Escherichia coli, Shigella flexneri, Salmonella spp. In Azorhizobium caulinodans, an hfq mutant is unable to express nifA, and Hfq is called NrfA, for nif regulatory factor (see PMID:8197116). The name hfq reflects phenomenology as a host factor for phage Q-beta RNA replication.