Protein Family Models for Gene (Select 29385800) - Protein Family Models

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GTP diphosphokinase

(p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP

Gene:: relA

GO Terms:

Biological Process:: guanosine tetraphosphate metabolic process (GO:0015969)

Date:: 2021-08-24

Family Accession:: NF008124.0
Method:: HMM

Select item 2169612.

RelA/SpoT family protein

The functions of E. coli RelA and SpoT differ somewhat. RelA (EC 2.7.6.5) produces pppGpp (or ppGpp) from ATP and GTP (or GDP). SpoT (EC 3.1.7.2) degrades ppGpp, but may also act as a secondary ppGpp synthetase. The two proteins are strongly similar. In many species, a single homolog to SpoT and RelA appears reponsible for both ppGpp synthesis and ppGpp degradation. (p)ppGpp is a regulatory metabolite of the stringent response, but appears also to be involved in antibiotic biosynthesis in some species.

GO Terms:

Biological Process:: stringent response (GO:0015968)

Biological Process:: guanosine tetraphosphate metabolic process (GO:0015969)

Date:: 2024-06-27

Family Accession:: TIGR00691.1
Method:: HMM

Protein Family Models

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