Protein Family Models for Gene (Select 39462663) - Protein Family Models

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Items: 6

Select item 4013221.

new record, indexing in progress

Family Accession:

Select item 3924242.

new record, indexing in progress

Family Accession:

Select item 3644323.

new record, indexing in progress

Family Accession:

Select item 3533434.

new record, indexing in progress

Family Accession:

Select item 2033315.

type II toxin-antitoxin system YafQ family toxin

type II toxin-antitoxin (TA) system YafQ family toxin similar to Escherichia coli YafQ, which functions as a sequence-specific mRNA endoribonuclease that inhibits translation elongation and induces bacterial stasis, and is the toxin component of the YafQ-DinJ TA module that plays a role in biofilm formation

Date:: 2017-08-03

Family Accession:: 11239005
Method:: Sparcle

Select item 499126.

type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family

Plasmids may be maintained stably in bacterial populations through the action of addiction modules, in which a toxin and antidote are encoded in a cassette on the plasmid. In any daughter cell that lacks the plasmid, the toxin persists and is lethal after the antidote protein is depleted. Toxin/antitoxin pairs are also found on main chromosomes, and likely represent selfish DNA. Sequences in the seed for this alignment all are found adjacent to RelB/DinJ family antitoxin genes (TIGR02384), as are most genes found by the resulting model. StbE from Morganella morganii plasmid R485 shows typical behaviour for an addiction module toxin. It cannot be cloned without its partner (the antitoxin), whereas its partner cannot confer plasmid stability without StbE.