Protein Family Models for Gene (Select 50229068) - Protein Family Models

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Select item 3894914.

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Select item 14195913.

dihydrolipoyl dehydrogenase

This HMM describes dihydrolipoamide dehydrogenase, a flavoprotein that acts in a number of ways. It is the E3 component of dehydrogenase complexes for pyruvate, 2-oxoglutarate, 2-oxoisovalerate, and acetoin. It can also serve as the L protein of the glycine cleavage system. This family includes a few members known to have distinct functions (ferric leghemoglobin reductase and NADH:ferredoxin oxidoreductase) but that may be predicted by homology to act as dihydrolipoamide dehydrogenase as well. The motif GGXCXXXGCXP near the N-terminus contains a redox-active disulfide.

Gene:: lpdA

GO Terms:

Molecular Function:: dihydrolipoyl dehydrogenase activity (GO:0004148)

Molecular Function:: flavin adenine dinucleotide binding (GO:0050660)

Date:: 2024-06-27

Family Accession:: TIGR01350.1
Method:: HMM

Select item 5285014.

dihydrolipoyl dehydrogenase family protein

dihydrolipoyl dehydrogenase family protein belonging to the class-I pyridine nucleotide-disulfide oxidoreductase superfamily may function as a FAD/NAD(P)-dependent oxidoreductase, similar to dihydrolipoyl dehydrogenase which catalyzes the oxidation of dihydrolipoamide to lipoamide and is often a component of multienzyme 2-oxo-acid dehydrogenase complexes

Date:: 2024-07-05

Family Accession:: 11441193
Method:: Sparcle

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