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23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN
23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN is a dual-specificity RNA methyltransferase that specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
Members of this family are RlmN, a 23S rRNA m2A2503 methyltransferase in the radical SAM enzyme family. Closely related is Cfr, a Staphylococcus sciuri plasmid-borne homolog to this family the confers transferrable resistance to chloramphenicol and florfenicol. Cfr methylates adenine(2503) of 23S RNA at position C(8), while RlmN methylates the same residue at a different site, position C(2).
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