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peptide chain release factor 2
The bacterial peptide chain release factor 2 (RF-2), product of the prfB gene, recognizes the stop codons UGA and UAA during protein translation, and it is the only release factor to recognize UGA. In about 80 percent of known bacterial species, a +1 frameshift must occur at a UGA stop codon about 25 amino acids from the N-terminus, or translation is aborted by a premature termination. RF-2 can therefore regulate its own production by readthrough only when RF-2 is insufficient.
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