Protein Family Models for Gene (Select 64182248) - Protein Family Models

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Items: 4

Select item 3910711.

new record, indexing in progress

Family Accession:

Select item 3486482.

new record, indexing in progress

Family Accession:

Select item 2537003.

Ku protein

Ku protein, together with LigD, forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity; binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA; recruits and stimulates the ligase activity of LigD

Date:: 2022-11-29

Family Accession:: 10092386
Method:: Sparcle

Select item 504434.

Ku protein

Members of this protein family are Ku proteins of non-homologous end joining (NHEJ) DNA repair in bacteria and in at least one member of the archaea (Archaeoglobus fulgidus). Most members are encoded by a gene adjacent to the gene for the DNA ligase that completes the repair. The NHEJ system is broadly but rather sparsely distributed, being present in about one fifth of the first 250 completed prokarytotic genomes. A few species (e.g. Archaeoglobus fulgidus and Bradyrhizobium japonicum) have multiple copies that appear to represent recent paralogous family expansion.

GO Terms: