Protein Family Models for Gene (Select 64223044) - Protein Family Models

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Items: 4

Select item 3890141.

new record, indexing in progress

Family Accession:

Select item 3472342.

new record, indexing in progress

Family Accession:

Select item 1424733.

iron-sulfur cluster assembly protein IscA

This HMM represents the IscA component of the ISC system for iron-sulfur cluster assembly. The ISC system consists of IscRASU, HscAB and an Isc-specific ferredoxin [1]. IscA previously was believed to act as a scaffold [3] and now is seen as an iron donor protein. This clade is limited to the proteobacteria.

Gene:: iscA

GO Terms:

Biological Process:: iron-sulfur cluster assembly (GO:0016226)

Molecular Function:: iron-sulfur cluster binding (GO:0051536)

Date:: 2024-06-27

Family Accession:: TIGR02011.1
Method:: HMM

Select item 169844.

iron-sulfur cluster assembly accessory protein

Proteins in this subfamily appear to be associated with the process of FeS-cluster assembly. The HesB proteins are associated with the nif gene cluster and the Rhizobium gene IscN has been shown to be required for nitrogen fixation [1]. Nitrogenase includes multiple FeS clusters and many genes for their assembly. The E. coli SufA protein is associated with SufS, a NifS homolog and SufD which are involved in the FeS cluster assembly of the FhnF protein [2]. The Azotobacter protein IscA (homologs of which are also found in E.coli) is associated which IscS, another NifS homolog and IscU, a nifU homolog as well as other factors consistent with a role in FeS cluster chemistry [3]. A homolog from Geobacter contains a selenocysteine in place of an otherwise invariant cysteine, further suggesting a role in redox chemistry.

GO Terms: