Protein Family Models for Gene (Select 66355213) - Protein Family Models

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Holliday junction branch migration DNA helicase RuvB

Holliday junction branch migration DNA helicase RuvB is an ATPase that forms a complex with RuvA; the helicase RuvAB mediates the Holliday junction migration by localized denaturation and reannealing

Date:: 2023-02-23

Family Accession:: 11477953
Method:: Sparcle

Select item 2165613.

Holliday junction branch migration DNA helicase RuvB

All proteins in this family for which functions are known are 5'-3' DNA helicases that, as part of a complex with RuvA homologs serve as a 5'-3' Holliday junction helicase. RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions.

Gene:: ruvB

GO Terms:

Molecular Function:: DNA binding (GO:0003677)

Molecular Function:: ATP binding (GO:0005524)

Biological Process:: DNA repair (GO:0006281)

Biological Process:: DNA recombination (GO:0006310)

Molecular Function:: four-way junction helicase activity (GO:0009378)

Date:: 2024-05-16

Family Accession:: TIGR00635.1
Method:: HMM

Select item 1729314.

Holliday junction branch migration DNA helicase RuvB

Promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration

Gene:: ruvB

GO Terms:

Molecular Function:: DNA binding (GO:0003677)

Molecular Function:: ATP binding (GO:0005524)

Biological Process:: DNA repair (GO:0006281)

Biological Process:: DNA recombination (GO:0006310)

Molecular Function:: four-way junction helicase activity (GO:0009378)

Date:: 2021-07-22

Family Accession:: NF000868.0
Method:: HMM

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