This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli.
GO Terms:- Biological Process:
- xenobiotic transmembrane transport (GO:0006855)
- Cellular Component:
- membrane (GO:0016020)
- Molecular Function:
- transmembrane transporter activity (GO:0022857)
- Date:
- 2024-06-14