Protein Family Models for Gene (Select 66453650) - Protein Family Models

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Items: 4

Select item 4001001.

new record, indexing in progress

Family Accession:

Select item 3577092.

new record, indexing in progress

Family Accession:

Select item 331863.

DNA polymerase III subunit delta'

Catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA

Gene:: holB

GO Terms:

Molecular Function:: DNA-directed DNA polymerase activity (GO:0003887)

Biological Process:: DNA replication (GO:0006260)

Molecular Function:: 3'-5' exonuclease activity (GO:0008408)

Date:: 2021-10-04

Family Accession:: NF005972.0
Method:: HMM

Select item 224284.

DNA polymerase III subunit delta'

This model describes the N-terminal half of the delta' subunit of DNA polymerase III. Delta' is homologous to the gamma and tau subunits, which form an outgroup for phylogenetic comparison. The gamma/tau branch of the tree is much more tighly conserved than the delta' branch, and some members of that branch score more highly against this model than some proteins classisified as delta'. The noise cutoff is set to detect weakly scoring delta' subunits rather than to exclude gamma/tau subunits. At position 126-127 of the seed alignment, this family lacks the HM motif of gamma/tau; at 132 it has a near-invariant A vs. an invariant F in gamma/tau.