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HigA family addiction module antitoxin
Members of this family form a distinct clade within the larger family HTH_3 of helix-turn-helix proteins, described by Pfam model PF01381. Members of this clade are strictly bacterial and nearly always shorter than 110 amino acids. This family includes the characterized member HigA, without which the killer protein HigB cannot be cloned. The hig (host inhibition of growth) system is noted to be unusual in that killer protein is uncoded by the upstream member of the gene pair.
helix-turn-helix domain-containing protein
helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator
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