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bifunctional aspartate kinase/homoserine dehydrogenase I
bifunctional aspartate kinase/homoserine dehydrogenase I catalyzes the phosphorylation of L-aspartate to 4-phospho-L-aspartate and the conversion of L-homoserine to L-aspartate-4-semialdehyde, the first and third steps of the aspartate pathway
aspartate kinase
Aspartate kinase catalyzes a first step in the biosynthesis from Asp of Lys (and its precursor diaminopimelate), Met, and Thr. Prokaryotic genomes frequently encode multiple aspartate kinases. In E. coli, a distinct isozyme is inhibited by each of the three amino acid products. The Met-sensitive (I) and Thr-sensitive (II) forms are bifunctional enzymes fused to homoserine dehydrogenases and form homotetramers, while the Lys-sensitive form (III) is a monofunctional homodimer.
bifunctional aspartate kinase/homoserine dehydrogenase II
Catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways
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