Protein Family Models

tRNA modification GTPase is involved in the modification of the wobble position of certain tRNAs and is one of the G proteins activated by nucleotide-dependent dimerization, such as bacterial MnmE and mitochondrial GTP-binding protein 3

Date:

2023-02-27

Gene:

mnmE

Date:

2021-07-23

MnmE, previously known as ThdF (thiophene and furan oxidation protein) and TrmE, is a GTPase involved in tRNA modification to create 5-met hylaminomethyl-2-thiouridine in the wobble position of some tRNAs. This protein and MnmG (previously GidA) form an alpha2/beta2 heterotetramer.

Gene:

mnmE

Date:

2021-07-23

Proteins with a small GTP-binding domain recognized by this model include Ras, RhoA, Rab11, translation elongation factor G, translation initiation factor IF-2, tetratcycline resistance protein TetM, CDC42, Era, ADP-ribosylation factors, tdhF, and many others. In some proteins the domain occurs more than once. This model recognizes a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model.

Date:

2022-03-28