Protein Family Models for Gene (Select 72397170) - Protein Family Models

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Select item 33949013.

isoleucine--tRNA ligase

isoleucine--tRNA ligase catalyzes the attachment of isoleucine to tRNA(Ile)

Date:: 2024-04-09

Family Accession:: 11414613
Method:: Sparcle

Select item 1844414.

isoleucine--tRNA ligase

The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. It catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile). Since isoleucine and other amino acids such as valine are similar, there is additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile). There are two active sites, one for aminoacylation and one for editing. Some organisms carry two different copies of this enzyme

Gene:: ileS

GO Terms:

Molecular Function:: nucleotide binding (GO:0000166)

Molecular Function:: isoleucine-tRNA ligase activity (GO:0004822)

Molecular Function:: ATP binding (GO:0005524)

Biological Process:: isoleucyl-tRNA aminoacylation (GO:0006428)

Date:: 2024-05-13

Family Accession:: TIGR00392.1
Method:: HMM

Protein Family Models

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