Protein Family Models for Gene (Select 75203722) - Protein Family Models

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Items: 5

Select item 3882871.

new record, indexing in progress

Family Accession:

Select item 3465962.

new record, indexing in progress

Family Accession:

Select item 2024303.

NADP-dependent isocitrate dehydrogenase

isocitrate dehydrogenase (NADP(+)) converts isocitrate to 2-oxoglutarate in an NADP-dependent manner

Date:: 2023-02-23

Family Accession:: 10012862
Method:: Sparcle

Select item 1625684.

NADP-dependent isocitrate dehydrogenase

Gene:: icd

GO Terms:

Molecular Function:: magnesium ion binding (GO:0000287)

Molecular Function:: isocitrate dehydrogenase (NADP+) activity (GO:0004450)

Biological Process:: tricarboxylic acid cycle (GO:0006099)

Molecular Function:: NAD binding (GO:0051287)

Date:: 2021-07-30

Family Accession:: NF005425.0
Method:: HMM

Select item 164315.

isocitrate dehydrogenase (NADP(+))

Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; Prokaryotic NADP-dependent isocitrate dehydrogenases resemble their NAD-dependent counterparts and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent isocitrate dehydrogenases.