Protein Family Models for Gene (Select 75203815) - Protein Family Models

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Items: 6

Select item 4050151.

new record, indexing in progress

Family Accession:

Select item 4009122.

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Family Accession:

Select item 3592863.

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Family Accession:

Select item 3577994.

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Family Accession:

Select item 599925.

NADPH-dependent 7-cyano-7-deazaguanine reductase

NADPH-dependent 7-cyano-7-deazaguanine reductase catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis

Date:: 2023-03-21

Family Accession:: 11485510
Method:: Sparcle

Select item 525906.

NADPH-dependent 7-cyano-7-deazaguanine reductase QueF

This enzyme catalyzes the 4-electron reduction of the cyano group of 7-cyano-7-deazaguanine (preQ0) to an amine. Although related to a large family of GTP cyclohydrolases (PF01227), the relationship is structural and not germane to the catalytic mechanism. This mode represents the longer, gram-negative version of the enzyme as found in E. coli. The enzymatic step represents the first point at which the biosynthesis of queuosine in bacteria and eukaryotes is distinguished from the biosynthesis of archaeosine in archaea.