Protein Family Models for Gene (Select 75203890) - Protein Family Models

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Items: 4

Select item 3901111.

new record, indexing in progress

Family Accession:

Select item 3468892.

new record, indexing in progress

Family Accession:

Select item 1962453.

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase is an enzyme involved in the biosynthesis of histidine, specifically catalyzing the fourth step in the pathway, by converting a specific intermediate molecule through an isomerization reaction

Date:: 2024-11-16

Family Accession:: 10792056
Method:: Sparcle

Select item 169744.

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase

This protein family consists of HisA, phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, the enzyme catalyzing the fourth step in histidine biosynthesis. It is closely related to the enzyme HisF for the sixth step. Examples of this enzyme in Actinobacteria have been found to be bifunctional, also possessing phosphoribosylanthranilate isomerase activity [1]; the trusted cutoff here has now been raised to 275.0 to exclude the bifunctional group, now represented by model TIGR01919. HisA from Lactococcus lactis was reported to be inactive (MEDLINE:93322317).