Protein Family Models

Gene:

gltA

Date:

2022-09-13

Forms citrate from oxaloacetate and acetyl-CoA; functions in TCA cycle, glyoxylate cycle and respiration

Date:

2020-10-26

Members of this family are dimeric enzymes with activity as 2-methylcitrate synthase, citrate synthase, or both. Many Gram-negative species have a hexameric citrate synthase, termed citrate synthase I (TIGR01798). Members of this family (TIGR01800) appear as a second citrate synthase isozyme but typically are associated with propionate metabolism and synthesize 2-methylcitrate from propionyl-CoA; citrate synthase activity may be incidental. A number of species, including Thermoplasma acidophilum, Pyrococcus furiosus, and the Antarctic bacterium DS2-3R have a bifunctional member of this family as the only citrate synthase isozyme.

Date:

2024-05-30

citrate synthase family protein similar to citrate synthase that catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) from citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle| citrate/2-methylcitrate synthase, citrate synthase forms citrate from oxaloacetate and acetyl-CoA; methylcitrate synthase catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also has minor citrate synthase activity

Date:

2017-03-02