Protein Family Models

membrane protein insertase YidC functions as a membrane protein chaperone and as an independent insertase for membrane proteins

Date:

2023-03-16

Gene:

yidC

Date:

2022-10-11

Gene:

yidC

Date:

2022-10-11

Gene:

yidC

Date:

2022-10-11

This model describes full-length from some species, and the C-terminal region only from other species, of the YidC/Oxa1 family of proteins. This domain appears to be univeral among bacteria (although absent from Archaea). The well-characterized YidC protein from Escherichia coli and its close homologs contain a large N-terminal periplasmic domain in addition to the region modeled here.

Gene:

yidC

Date:

2024-08-07

Essentially all bacteria have a member of the YidC family, whose C-terminal domain is modeled by TIGR03592. The two copies are found in endospore-forming bacteria such as Bacillus subtilis appear redundant during vegetative growth, although the member designated spoIIIJ (stage III sporulation protein J) has a distinct role in spore formation. YidC, its mitochondrial homolog Oxa1, and its chloroplast homolog direct insertion into the bacterial/organellar inner (or only) membrane. This model describes an N-terminal sequence region, including a large periplasmic domain lacking in YidC members from Gram-positive species. The multifunctional YidC protein acts both with and independently of the Sec system.

Gene:

yidC

Date:

2024-08-07