Protein Family Models

PrlF_antitoxin is a family of bacterial antitoxins that neutralises the toxin YhaV. PrlF is labile and forms a homodimer that then binds to the YhaV toxin thereby neutralising its ribonuclease activity. Alone, it can also act as a transcription factor. The YhaV/PrlF complex binds the prlF-yhaV operon, probably regulating its expression negatively. Over-expression of PrlF leads to increased doubling time [1]. [1]. 2152898. Increased expression of the bifunctional protein PrlF suppresses overproduction lethality associated with exported beta-galactosidase hybrid proteins in Escherichia coli. Kiino DR, Phillips GJ, Silhavy TJ;. J Bacteriol 1990;172:185-192. [2]. 17706670. prlF and yhaV encode a new toxin-antitoxin system in Escherichia coli. Schmidt O, Schuenemann VJ, Hand NJ, Silhavy TJ, Martin J, Lupas AN, Djuranovic S;. J Mol Biol. 2007;372:894-905. (from Pfam)

Date:

2024-10-16

Date:

2020-10-26

type II toxin-antitoxin (TA) system PrlF family antitoxin similar to Escherichia coli PrlF, the antitoxin component of the YhaV/PrlF TA system; it binds to the YhaV toxin and neutralizes its ribonuclease activity, and also acts as a transcription factor

Date:

2017-07-26