Protein Family Models

This entry includes calcium-activated potassium channels, known as BK channels or Slowpoke homologues (Slo1-3) which includes calcium-activated potassium channel slowpoke from Drosophila (Slo) and its homologues from vertebrates KCMA1, KCNT1/2 and KCNU1. This entry represents the C-terminal regulator of K+ conductance (RCK) domains which appear as tandem domains in these proteins [1-5]. The RCK domain has a Rossmann-fold topology with unique positions that compose a well-conserved salt bridge and a hydrophobic dimer interface. This domain is also presents in prokaryotic K+ channels. Paper describing PDB structure 1id1. [1]. 11301020. Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel. Jiang Y, Pico A, Cadene M, Chait BT, MacKinnon R;. Neuron. 2001;29:593-601. Paper describing PDB structure 1lnq. [2]. 12037559. Crystal structure and mechanism of a calcium-gated potassium channel. Jiang Y, Lee A, Chen J, Cadene M, Chait BT, MacKinnon R;. Nature. 2002;417:515-522. Paper describing PDB structure 2aef. [3]. 16227203. Structures of the MthK RCK domain and the effect of Ca2+ on gating ring stability. Dong J, Shi N, Berke I, Chen L, Jiang Y;. J Biol Chem. 2005;280:41716-41724. Paper describing PDB structure 2fy8. [4]. 16990139. Crystal structures of a ligand-free MthK gating ring: insights into the ligand gating mechanism of K+ channels. Ye S, Li Y, Chen L, Jiang Y;. Cell. 2006;126:1161-1173. Paper describing PDB structure 2ogu. [5]. 17287352. Dynamic oligomeric conversions of the cytoplasmic RCK domains mediate MthK potassium channel activity. Kuo MM, Baker KA, Wong . TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-10-29

This family includes the two membrane helix type ion channels found in bacteria. [1]. 11836519. Potassium channel structures. Choe S;. Nat Rev Neurosci 2002;3:115-121. (from Pfam)

Date:

2024-10-16

This domain is found in a wide variety of proteins. These protein include potassium channels Swiss:P31069, phosphoesterases Swiss:Q59027, and various other transporters. This domain binds to NAD. Domain called KTN in figure 2. [1]. 9478130. A novel family of predicted phosphoesterases includes Drosophila prune protein and bacterial RecJ exonuclease. Aravind L, Koonin EV;. Trends Biochem Sci 1998;23:17-19. [2]. 8412700. NAD+ binding to the Escherichia coli K(+)-uptake protein TrkA and sequence similarity between TrkA and domains of a family of dehydrogenases suggest a role for NAD+ in bacterial transport. Schlosser A, Hamann A, Bossemeyer D, Schneider E, Bakker EP;. Mol Microbiol 1993;9:533-543. Called TRKA-N domain. See alignment in figure 8a. [3]. 11292341. Regulatory potential, phyletic distribution and evolution of ancient, intracellular small-molecule-binding domains. Anantharaman V, Koonin EV, Aravind L;. J Mol Biol 2001;307:1271-1292. (from Pfam)

Date:

2024-10-16

potassium channel family protein spans the cell membrane to form a conduction pathway or pore, through which selective ions such as potassium, sodium, and calcium translocate across cell membranes, similar to Trk system potassium uptake protein TrkA

Date:

2024-07-12