Protein Family Models

This family consists of proline racemase (EC 5.1.1.4) proteins which catalyse the interconversion of L- and D-proline in bacteria [1]. This family also contains several similar eukaryotic proteins including Swiss:Q9NCP4 a sequence with B-cell mitogenic properties which has been characterised as a co-factor-independent proline racemase [2]. [1]. 3755058. Energetics of proline racemase: racemization of unlabeled proline in the unsaturated, saturated, and oversaturated regimes. Fisher LM, Albery WJ, Knowles JR;. Biochemistry 1986;25:2529-2537. [2]. 10932226. A B-cell mitogen from a pathogenic trypanosome is a eukaryotic proline racemase. Reina-San-Martin B, Degrave W, Rougeot C, Cosson A, Chamond N, Cordeiro-Da-Silva A, Arala-Chaves M, Coutinho A, Minoprio P;. Nat Med 2000;6:890-897. (from Pfam)

Date:

2024-10-16

proline racemase family protein similar to trans-3-hydroxy-L-proline (t3LHyp) dehydratase (aka 4-hydroxyproline 2-epimerase) that catalyzes the dehydration of t3LHyp to delta(1)-pyrroline-2-carboxylate (Pyr2C), and the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp)

Date:

2019-11-20