Protein Family Models

This family includes Succinylglutamate desuccinylase EC:3.1.-.- that catalyses the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway. The family also include aspartoacylase EC:3.5.1.15 which cleaves acylaspartate into a fatty acid and aspartate. Mutations in Swiss:P45381 lead to Canavan disease disease [1]. This family is probably structurally related to Pfam:PF00246 (Bateman A pers. obs.). [1]. 8252036. Cloning of the human aspartoacylase cDNA and a common missense mutation in Canavan disease. Kaul R, Gao GP, Balamurugan K, Matalon R;. Nat Genet 1993;5:118-123. (from Pfam)

Date:

2024-10-16

succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) family protein which belongs to the ASTE/ASPA subfamily of the M14 family of metallocarboxypeptidases; ASTE cleaves N-succinyl-L-glutamate into succinate and L-glutamate (the last step in the arginine succinyltransferase (AST) pathway for the catabolism of arginine), and ASPA cleaves N-acetyl L-aspartic acid into aspartate and acetate

Date:

2019-08-27