Protein Family Models

This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells [2]. Ca2+ is moved into or out of the cytosol depending on Na+ concentration [2]. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3 [1] see Swiss:Q01728, Swiss:P48768 and Swiss:P70549 respectively. [1]. 8798769. Cloning of a third mammalian Na+-Ca2+ exchanger, NCX3. Nicoll DA, Quednau BD, Qui Z, Xia YR, Lusis AJ, Philipson KD;. J Biol Chem 1996;271:24914-24921. [2]. 1700476. Molecular cloning and functional expression of the cardiac sarcolemmal Na(+)-Ca2+ exchanger. Nicoll DA, Longoni S, Philipson KD;. Science 1990;250:562-565. (from Pfam)

Date:

2024-10-16

The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19) Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria. All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange. This Hmm is generated from the calcium ion/proton exchangers of the CacA family.

Gene:

chaA

Date:

2022-03-28

Gene:

cax

Date:

2024-06-10