Protein Family Models

This family represents a number of fimbrial protein transcription regulators found in Gram-negative bacteria. These proteins are thought to facilitate binding of the leucine-rich regulatory protein to regulatory elements, possibly by inhibiting deoxyadenosine methylation of these elements by deoxyadenosine methylase [1,2]. [1]. 7476191. Negative control of fae (K88) expression by the 'global' regulator Lrp is modulated by the 'local' regulator FaeA and affected by DNA methylation. Huisman TT, de Graaf FK;. Mol Microbiol 1995;16:943-953. [2]. 8846772. Differential binding of Lrp to two sets of pap DNA binding sites mediated by Pap I regulates Pap phase variation in Escherichia coli. Nou X, Braaten B, Kaltenbach L, Low DA;. EMBO J 1995;14:5785-5797. (from Pfam)

Date:

2024-10-16

Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition. [1]. 9466913. Crystal structure of the cyanobacterial metallothionein repressor SmtB: a model for metalloregulatory proteins. Cook WJ, Kar SR, Taylor KB, Hall LM;. J Mol Biol 1998;275:337-346. (from Pfam)

Date:

2024-10-16

winged helix-turn-helix (wHTH) domain-containing protein with an ArsR family wHTH domain, binds DNA and may function as a transcriptional regulator

Date:

2024-04-16