Protein Family Models for Protein (Select 1027773236) - Protein Family Models

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Items: 4

Select item 4146931.

PrpF domain-containing protein

PrpF is a protein found in the 2-methylcitrate pathway. It is structurally similar to DAP epimerase and proline racemase. This protein is likely to acts to isomerise trans-aconitate to cis-aconitate [1]. [1]. 17567742. The three-dimensional crystal structure of the PrpF protein of Shewanella oneidensis complexed with trans-aconitate: insights into its biological function. Garvey GS, Rocco CJ, Escalante-Semerena JC, Rayment I;. Protein Sci. 2007;16:1274-1284. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF016210.5
Method:: HMM

Select item 3906602.

new record, indexing in progress

Family Accession:

Select item 3501043.

new record, indexing in progress

Family Accession:

Select item 491234.

2-methylaconitate cis-trans isomerase PrpF

The 2-methylcitrate cycle is one of at least five degradation pathways for propionate via propionyl-CoA. Degradation of propionate toward pyruvate consumes oxaloacetate and releases succinate. Oxidation of succinate back into oxaloacetate by the TCA cycle makes the 2-methylcitrate pathway a cycle. This family consists of PrpF, an incompletely characterized protein that appears to be an essential accessory protein for the Fe/S-dependent 2-methylisocitrate dehydratase AcnD (TIGR02333). This protein is related to but distinct from FldA (part of Pfam family PF04303), a putative fluorene degradation protein of Sphingomonas sp. LB126.