Protein Family Models

This entry represents a small domain found at the C-terminus of RecA. The recA gene product is a multifunctional enzyme that plays a role in homologous recombination, DNA repair and induction of the SOS response This domain adopts a structure composed of a beta hairpin and three alpha helices. It has been shown to bind to dsDNA [1]. Paper describing PDB structure 1aa3. [1]. 9398528. An interaction between a specified surface of the C-terminal domain of RecA protein and double-stranded DNA for homologous pairing. Aihara H, Ito Y, Kurumizaka H, Terada T, Yokoyama S, Shibata T;. J Mol Biol. 1997;274:213-221. Paper describing PDB structure 1g18. [2]. 11121488. Crystal structures of Mycobacterium tuberculosis RecA and its complex with ADP-AlF(4): implications for decreased ATPase activity and molecular aggregation. Datta S, Prabu MM, Vaze MB, Ganesh N, Chandra NR, Muniyappa K, Vijayan M;. Nucleic Acids Res. 2000;28:4964-4973. Paper describing PDB structure 1n03. [3]. 12575938. ATP-mediated conformational changes in the RecA filament. VanLoock MS, Yu X, Yang S, Lai AL, Low C, Campbell MJ, Egelman EH;. Structure. 2003;11:187-196. Paper describing PDB structure 1u94. [4]. 15364575. Crystal structures of Escherichia coli RecA in a compressed helical filament. Xing X, Bell CE;. J Mol Biol. 2004;342:1471-1485. Paper describing PDB structure 1ubc. [5]. 12837805. Crystal structures of Mycobacterium smegmatis RecA and its nucleotide complexes. Datta S, Krishna R, Ganesh N, Chandra NR, Muniyappa K, Vijayan M;. J Bacteriol. 2003;185:4280-4284. (from Pfam)

Date:

2024-10-16

Rad51 is a DNA repair and recombination protein and is a homologue of the bacterial ATPase RecA protein. [1]. 16169964. Arabidopsis RAD51C gene is important for homologous recombination in meiosis and mitosis. Abe K, Osakabe K, Nakayama S, Endo M, Tagiri A, Todoriki S, Ichikawa H, Toki S;. Plant Physiol. 2005;139:896-908. (from Pfam)

Date:

2024-10-16

RecA is a DNA-dependent ATPase and functions in DNA repair systems. RecA protein catalyses an ATP-dependent DNA strand-exchange reaction that is the central step in the repair of dsDNA breaks by homologous recombination [1]. [1]. 7022448. recA protein of Escherichia coli promotes branch migration, a kinetically distinct phase of DNA strand exchange. Cox MM, Lehman IR;. Proc Natl Acad Sci U S A. 1981;78:3433-3437. (from Pfam)

Date:

2024-10-16

This model describes orthologs of the recA protein. RecA promotes hybridization of homolgous regions of DNA. A segment of ssDNA can be hybridized to another ssDNA region, or to a dsDNA region. ATP is hydrolyzed in the process. Part of the SOS respones, it is regulated by LexA via autocatalytic cleavage.

Gene:

recA

Date:

2024-05-14

recombinase RecA catalyzes an ATP-dependent DNA strand-exchange reaction, which is a critical step in the repair of DNA double-strand breaks by homologous recombination

Date:

2024-05-13