Protein Family Models for Protein (Select 1056804846) - Protein Family Models

Select item 4231801.

SusD/RagB family nutrient-binding outer membrane lipoprotein

SusD is a secreted starch-binding protein with an N-terminal lipid tail that allows it to associate with the outer membrane. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF024181.5
Method:: HMM

Select item 4225642.

RagB/SusD family nutrient uptake outer membrane protein

SusD is a secreted polysaccharide-binding protein with an N-terminal lipid moiety that allows it to associate with the outer membrane. SusD probably mediates xyloglucan-binding prior to xyloglucan transport in the periplasm for degradation [1]. This domain is found N-terminal to Pfam:PF07980. [1]. 24463512. A discrete genetic locus confers xyloglucan metabolism in select human gut Bacteroidetes. Larsbrink J, Rogers TE, Hemsworth GR, McKee LS, Tauzin AS, Spadiut O, Klinter S, Pudlo NA, Urs K, Koropatkin NM, Creagh AL, Haynes CA, Kelly AG, Cederholm SN, Davies GJ, Martens EC, Brumer H;. Nature. 2014;506:498-502. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF025680.5
Method:: HMM

Select item 4213243.

SusD/RagB family nutrient-binding outer membrane lipoprotein

This is a family of SusD-like proteins, one member of which, BT1043 (Swiss:Q8A8X4), is an outer membrane lipoprotein involved in host glycan metabolism. The structures of this and SusD-homologues in the family are dominated by tetratrico peptide repeats that may facilitate association with outer membrane beta-barrel transporters required for glycan uptake. The structure of BT1043 complexed with N-acetyllactosamine reveals that recognition is mediated via hydrogen bonding interactions with the reducing end of beta-N-acetylglucosamine, suggesting a role in binding glycans liberated from the mucin polypeptide. Mammalian distal gut bacteria have an expanded capacity to utilize glycans. In the absence of dietary sources, some species rely on host-derived mucosal glycans. The ability of Bacteroides thetaiotaomicron, a prominent human gut symbiont, to forage host glycans contributes to both its ability to persist within an individual host and its ability to be transmitted naturally to new hosts at birth. [1]. 19191477. Structure of a SusD homologue, BT1043, involved in mucin O-glycan utilization in a prominent human gut symbiont. Koropatkin N, Martens EC, Gordon JI, Smith TJ;. Biochemistry. 2009;48:1532-1542. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF024152.5
Method:: HMM

Select item 4020154.