Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
DUF4872 domain-containing protein
Members of this family are often found in the gene neighbourhood, or fused to, non-ribosomal peptide synthetases. [1]. 20023723. Amidoligases with ATP-grasp, glutamine synthetase-like and acetyltransferase-like domains: synthesis of novel metabolites and peptide modifications of proteins. Iyer LM, Abhiman S, Maxwell Burroughs A, Aravind L;. Mol Biosyst. 2009;5:1636-1660. (from Pfam)
BtrH N-terminal domain-containing protein
BtrH_N is the N-terminus of the acyl carrier protein:aminoglycoside acyltransferase BtrH. Alternatively it can be referred to as butirosin biosynthesis protein H. BtrH transfers the unique (S)-4-amino-2-hydroxybutyrate (AHBA) side chain, which protects the antibiotic butirosin from several common resistance mechanisms. Butirosin, an aminoglycoside antibiotic produced by Bacillus circulans, exhibits improved antibiotic properties over its parent molecule and retains bactericidal activity toward many aminoglycoside-resistant strains. Butirosin is unique in carrying the AHBA side-chain. BtrH transfers the AHBA from the acyl carrier protein BtrI to the parent aminoglycoside ribostamycin as a gamma-glutamylated dipeptide [1,2]. [1]. 16156513. Extended sequence and functional analysis of the butirosin biosynthetic gene cluster in Bacillus circulans SANK 72073. Kudo F, Numakura M, Tamegai H, Yamamoto H, Eguchi T, Kakinuma K;. J Antibiot (Tokyo). 2005;58:373-379. [2]. 20851126. Structural and biochemical studies elucidate the mechanism of rhamnogalacturonan lyase from Aspergillus aculeatus. Jensen MH, Otten H, Christensen U, Borchert TV, Christensen LL, Larsen S, Leggio LL;. J Mol Biol. 2010;404:100-111. (from Pfam)
BtrH N-terminal domain-containing protein similar to the N-terminal domain of Bacillus circulans butirosin biosynthesis protein H (BtrH), an aminoglycoside acyltransferase that attaches the (S)-4-amino-2-hydroxybutyrate side chain from the acyl carrier protein BtrI to the aminoglycoside ribostamycin in the biosynthetic pathway of butirosin; also contains a DUF4872 domain
Filter your results:
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on